Published in Science on August 30, 2002
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell (2004) 6.08
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet (2008) 5.44
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
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Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci (2003) 3.83
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An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron (2009) 3.34
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J (2010) 3.18
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proc Natl Acad Sci U S A (2005) 2.83
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LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. Neuron (2009) 2.60
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LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling. Neuron (2008) 2.23
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis. Trends Cell Biol (2008) 1.99
An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron (2007) 1.98
How to build a central synapse: clues from cell culture. Trends Neurosci (2005) 1.94
Open syntaxin docks synaptic vesicles. PLoS Biol (2007) 1.90
Virus cell-to-cell transmission. J Virol (2010) 1.84
Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses. Nat Neurosci (2009) 1.83
Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A (2007) 1.74
A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Nat Neurosci (2007) 1.72
Genetics and cell biology of building specific synaptic connectivity. Annu Rev Neurosci (2010) 1.71
Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci (2006) 1.66
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci (2009) 1.65
Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc Natl Acad Sci U S A (2005) 1.64
The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science (2013) 1.64
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet (2012) 1.64
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. J Cell Biol (2007) 1.63
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Proc Natl Acad Sci U S A (2002) 1.62
Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58
The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol (2011) 1.56
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J (2009) 1.50
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Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PLoS One (2014) 1.46
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol Cell Neurosci (2004) 1.42
BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions. J Cell Biol (2006) 1.41
Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci (2006) 1.32
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32
Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30
Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A (2011) 1.30
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. Neuron (2013) 1.30
Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc Natl Acad Sci U S A (2010) 1.30
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron (2007) 1.30
The membrane proteome of the mouse lens fiber cell. Mol Vis (2009) 1.30
Rapid assembly of functional presynaptic boutons triggered by adhesive contacts. J Neurosci (2009) 1.26
Signal regulatory proteins (SIRPS) are secreted presynaptic organizing molecules. J Biol Chem (2008) 1.24
Ephrin regulation of synapse formation, function and plasticity. Mol Cell Neurosci (2012) 1.23
SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron (2010) 1.22
Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression. Transl Psychiatry (2012) 1.20
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci U S A (2003) 1.19
Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology (2008) 1.19
Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol Cell Biol (2006) 1.19
Synapse microarray identification of small molecules that enhance synaptogenesis. Nat Commun (2011) 1.19
SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones. Proc Natl Acad Sci U S A (2010) 1.18
Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1. Proc Natl Acad Sci U S A (2009) 1.18
Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily. Mol Cell Biol (2006) 1.17
Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior. J Neurosci (2012) 1.14
SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol (2008) 1.14
Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron (2012) 1.14
The actin cytoskeleton in presynaptic assembly. Cell Adh Migr (2013) 1.11
Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions. J Comp Neurol (2008) 1.10
Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins. J Neurosci (2010) 1.10
Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol (2009) 1.09
Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation. Genes Dev (2007) 1.07
Signaling by synaptogenic molecules. Curr Opin Neurobiol (2008) 1.06
Gene networks and the neuroendocrine regulation of puberty. Mol Cell Endocrinol (2009) 1.06
Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation. EMBO J (2011) 1.06
Gene expression patterns in visual cortex during the critical period: synaptic stabilization and reversal by visual deprivation. Proc Natl Acad Sci U S A (2008) 1.05
The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. J Cell Biol (2012) 1.05
N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion. J Biol Chem (2010) 1.04
A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem (2011) 1.04
Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Nat Chem Biol (2005) 1.02
The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc Natl Acad Sci U S A (2004) 1.00
Regulation of synaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci U S A (2010) 1.00
Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. J Biol Chem (2009) 0.99
SynCAM1 recruits NMDA receptors via protein 4.1B. Mol Cell Neurosci (2009) 0.99
Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development. J Cell Biol (2013) 0.99
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Dis (2010) 0.99
In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J Cell Biol (2007) 0.98
Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β1-integrin. J Comp Neurol (2012) 0.98
Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS. J Neurosci (2008) 0.97
Spatial control of exocytosis. Curr Opin Cell Biol (2003) 0.97
γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting. J Biol Chem (2012) 0.96
A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis elegans. Neural Dev (2011) 0.96
Target-cell-specific short-term plasticity in local circuits. Front Synaptic Neurosci (2013) 0.96
CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23. BMC Cancer (2008) 0.95
Neuroligin-2 accelerates GABAergic synapse maturation in cerebellar granule cells. Mol Cell Neurosci (2009) 0.95
CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem (2010) 0.94
Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol Cancer (2005) 0.94
Alternative splicing of neuroligin regulates the rate of presynaptic differentiation. J Neurosci (2010) 0.94
A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans. EMBO J (2011) 0.94
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature (2011) 6.40
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci (2010) 4.94
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission. Neuron (2005) 4.05
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell (2011) 3.79
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell (2013) 2.39
Chemical and genetic engineering of selective ion channel-ligand interactions. Science (2011) 2.37
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29
MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr Biol (2006) 2.25
TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci (2005) 2.21
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation. J Neurosci (2008) 2.18
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission. Neuron (2012) 2.08
Spontaneous and evoked glutamate release activates two populations of NMDA receptors with limited overlap. J Neurosci (2008) 2.08
Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A (2003) 2.07
Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. Neuron (2009) 2.03
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol (2003) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
A neural circuit for memory specificity and generalization. Science (2013) 1.96
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91
Automatic reconstruction of 3D neuron structures using a graph-augmented deformable model. Bioinformatics (2010) 1.90
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron (2011) 1.89
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J (2002) 1.88
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. J Neurosci (2005) 1.87
Development of vesicle pools during maturation of hippocampal synapses. J Neurosci (2002) 1.87