Published in Endocrinology on April 14, 2005
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A (2007) 2.66
Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology (2010) 2.23
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology (2007) 1.98
Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology (2011) 1.75
Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology (2008) 1.63
Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology (2008) 1.60
Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology (2011) 1.55
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience (2010) 1.49
Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab (2009) 1.40
Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology (2009) 1.39
GnRH signaling, the gonadotrope and endocrine control of fertility. Front Neuroendocrinol (2010) 1.23
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol (2011) 1.17
Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol (2010) 1.17
Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One (2010) 1.17
Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology (2011) 1.14
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and Kiss1 in neonatal male and female rats. J Comp Neurol (2011) 1.14
Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat. Endocrinology (2008) 1.12
BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology (2010) 1.12
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol (2007) 1.11
New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons. Front Endocrinol (Lausanne) (2012) 1.09
Driving reproduction: RFamide peptides behind the wheel. Horm Behav (2006) 1.06
Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology (2010) 1.06
Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides (2008) 1.04
Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol Reprod (2010) 1.03
Circadian control of neuroendocrine circuits regulating female reproductive function. Front Endocrinol (Lausanne) (2012) 1.03
Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in an estradiol-dependent manner. Endocrinology (2009) 1.03
Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women. Front Endocrinol (Lausanne) (2011) 1.02
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology (2012) 1.02
Suppression of kisspeptin expression and gonadotropic axis sensitivity following exposure to inhibitory day lengths in female Siberian hamsters. Horm Behav (2007) 1.01
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques. Endocrinology (2010) 1.01
Kisspeptin and KISS1R: a critical pathway in the reproductive system. Reproduction (2008) 1.01
Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol (2009) 1.01
Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology (2012) 0.99
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
Neuroendocrine consequences of androgen excess in female rodents. Horm Behav (2008) 0.98
Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci (2013) 0.98
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol (2013) 0.97
Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland. Environ Health Perspect (2009) 0.96
International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol Rev (2010) 0.95
Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology (2011) 0.95
Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice. Endocrinology (2013) 0.95
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol (2013) 0.94
Photic and nonphotic seasonal cues differentially engage hypothalamic kisspeptin and RFamide-related peptide mRNA expression in Siberian hamsters. J Neuroendocrinol (2009) 0.93
Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology (2012) 0.93
Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction? Proc Biol Sci (2008) 0.92
Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells. J Neuroendocrinol (2011) 0.92
Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J Comp Neurol (2013) 0.91
Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat Rev Endocrinol (2013) 0.91
Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol (2013) 0.91
Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev (2008) 0.91
Photoperiod and testosterone interact to drive seasonal changes in kisspeptin expression in Siberian hamsters (Phodopus sungorus). J Neuroendocrinol (2008) 0.90
Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology (2012) 0.90
Kisspeptin neurons from mice to men: similarities and differences. Endocrinology (2012) 0.90
Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. J Neuroendocrinol (2013) 0.89
Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology (2012) 0.89
Kisspeptin excitation of GnRH neurons. Adv Exp Med Biol (2013) 0.89
Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. Endocrinology (2013) 0.89
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat. Reprod Toxicol (2010) 0.88
Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci (2014) 0.88
Expression of fos and in vivo median eminence release of LHRH identifies an active role for preoptic area kisspeptin neurons in synchronized surges of LH and LHRH in the ewe. Endocrinology (2010) 0.88
Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain. Front Endocrinol (Lausanne) (2012) 0.87
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals. Front Endocrinol (Lausanne) (2012) 0.87
Kisspeptins and RFRP-3 Act in Concert to Synchronize Rodent Reproduction with Seasons. Front Neurosci (2013) 0.86
Organizational and activational effects of sex steroids on kisspeptin neuron development. Front Neuroendocrinol (2012) 0.86
The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1). Front Neuroendocrinol (2014) 0.85
Dynamic postnatal developmental and sex-specific neuroendocrine effects of prenatal polychlorinated biphenyls in rats. Mol Endocrinol (2013) 0.85
Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. Endocrinology (2012) 0.85
Electrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in goats. J Reprod Dev (2012) 0.85
Neuroestrogen, rapid action of estradiol, and GnRH neurons. Front Neuroendocrinol (2012) 0.85
Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance. Front Endocrinol (Lausanne) (2011) 0.84
Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females. Endocrinology (2013) 0.84
Kisspeptin and clinical disorders. Adv Exp Med Biol (2013) 0.84
Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology (2011) 0.83
Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene. Int J Dev Neurosci (2013) 0.83
Neurons that co-localize aromatase- and kisspeptin-like immunoreactivity may regulate the HPG axis of the Mallard drake (Anas platyrhynchos). Gen Comp Endocrinol (2010) 0.83
Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse. Am J Physiol Endocrinol Metab (2009) 0.82
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. BMC Genomics (2011) 0.82
Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones. J Neuroendocrinol (2009) 0.82
Regulation of the female rat estrous cycle by a neural cell-specific epidermal growth factor-like repeat domain containing protein, NELL2. Mol Cells (2011) 0.82
Progesterone treatment inhibits and dihydrotestosterone (DHT) treatment potentiates voltage-gated calcium currents in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology (2010) 0.81
Voltage-gated potassium currents are targets of diurnal changes in estradiol feedback regulation and kisspeptin action on gonadotropin-releasing hormone neurons in mice. Biol Reprod (2011) 0.81
Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. Endocr Rev (2015) 0.81
Circadian regulation of kisspeptin in female reproductive functioning. Adv Exp Med Biol (2013) 0.81
The kisspeptin signaling pathway and its role in human isolated GnRH deficiency. Mol Cell Endocrinol (2011) 0.81
Prenatal influence of an androgen agonist and antagonist on the differentiation of the ovine sexually dimorphic nucleus in male and female lamb fetuses. Endocrinology (2014) 0.80
The physiological role of arcuate kisspeptin neurons in the control of reproductive function in female rats. Endocrinology (2013) 0.80
Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice. Endocrinology (2015) 0.80
The development of kisspeptin circuits in the Mammalian brain. Adv Exp Med Biol (2013) 0.80
Afferent neuronal control of type-I gonadotropin releasing hormone neurons in the human. Front Endocrinol (Lausanne) (2013) 0.79
Kisspeptin/G protein-coupled receptor-54 system as an essential gatekeeper of pubertal development. Ann Pediatr Endocrinol Metab (2013) 0.79
Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling. Endocrinology (2015) 0.78
Prenatal alcohol exposure alters response of kisspeptin-ir neurons to estradiol and progesterone in adult female rats. Alcohol Clin Exp Res (2014) 0.78
Kisspeptin and the hypothalamic control of reproduction: lessons from the human. Endocrinology (2012) 0.78
Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain. J Neuroendocrinol (2012) 0.78
Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet (2004) 5.75
Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology (2005) 4.48
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci (2005) 4.04
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology (2005) 3.52
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science (2010) 3.33
Pathway to totipotency: lessons from germ cells. Cell (2006) 3.02
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci (2006) 2.42
Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development (2004) 2.30
Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci U S A (2005) 2.25
Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology (2007) 2.20
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A (2006) 2.01
Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A (2006) 1.85
Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice. Genesis (2008) 1.83
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab (2010) 1.76
Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology (2011) 1.75
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology (2005) 1.75
The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci (2007) 1.69
Germline stem cells. Cold Spring Harb Perspect Biol (2011) 1.53
The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol (2008) 1.53
Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism. Endocrinology (2003) 1.52
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci (2007) 1.43
Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci (2009) 1.41
The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci (2007) 1.41
Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab (2009) 1.40
Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology (2009) 1.39
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction (2006) 1.32
Hormonal regulation of spermatogenesis. Int J Androl (2004) 1.24
Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology (2002) 1.23
Translational repression by MSY4 inhibits spermatid differentiation in mice. Development (2002) 1.21
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A (2012) 1.21
TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress. Mol Cell Biol (2008) 1.18
Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia. Dev Biol (2006) 1.16
Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol (2007) 1.14
Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci (2012) 1.13
Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. PLoS One (2012) 1.11
Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinology (2007) 1.10
A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology (2003) 1.10
Germ cell migration across Sertoli cell tight junctions. Science (2012) 1.09
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2003) 1.07
Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (2010) 1.06
Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development. Mol Endocrinol (2007) 1.05
NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice. J Clin Invest (2010) 1.03
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology (2012) 1.02
A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy. Aging Cell (2009) 1.01
Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells. Mol Endocrinol (2009) 1.00
Disruption of murine Tenr results in teratospermia and male infertility. Dev Biol (2005) 1.00
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2). Mol Cell Biol (2005) 0.98
Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology (2004) 0.97
Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl (2009) 0.94
Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice. Biol Reprod (2011) 0.93
Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy. Aging Cell (2012) 0.92
Hormonal regulation of testicular steroid and cholesterol homeostasis. Mol Endocrinol (2007) 0.92
Proteolytic mechanisms in the ovulatory folliculo-luteal transformation. Connect Tissue Res (2003) 0.92
Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab (2004) 0.91
Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology (2003) 0.89