Published in Neuroendocrinology on January 05, 2005
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A (2007) 2.66
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab (2011) 1.99
Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology (2007) 1.98
The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med (2008) 1.87
The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol (2009) 1.81
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab (2010) 1.76
The pros and cons of phytoestrogens. Front Neuroendocrinol (2010) 1.69
Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology (2008) 1.66
Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology (2008) 1.63
Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A (2010) 1.62
Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology (2008) 1.60
Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest (2014) 1.58
Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology (2011) 1.55
Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides (2008) 1.54
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Sex differences in the brain: the relation between structure and function. Horm Behav (2009) 1.47
Leptin in human physiology and therapeutics. Front Neuroendocrinol (2010) 1.46
Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology (2009) 1.44
Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One (2009) 1.42
Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology (2008) 1.29
Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor. Neuroendocrinology (2011) 1.24
GnRH signaling, the gonadotrope and endocrine control of fertility. Front Neuroendocrinol (2010) 1.23
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab (2011) 1.23
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism (2014) 1.18
Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol (2011) 1.17
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol (2011) 1.17
Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol (2010) 1.17
Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. Endocrinology (2008) 1.16
Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. Endocrinology (2012) 1.15
Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology (2011) 1.14
The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update (2014) 1.13
Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology (2008) 1.13
Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. Neurotoxicology (2009) 1.11
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol (2007) 1.11
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology (2011) 1.10
The KISS1 metastasis suppressor: mechanistic insights and clinical utility. Front Biosci (2006) 1.09
Anatomy of the kisspeptin neural network in mammals. Brain Res (2010) 1.09
New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons. Front Endocrinol (Lausanne) (2012) 1.09
The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab (2011) 1.08
Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology (2011) 1.08
Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem (2008) 1.08
The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats. Endocrinology (2009) 1.07
Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology (2010) 1.06
Driving reproduction: RFamide peptides behind the wheel. Horm Behav (2006) 1.06
Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol (2014) 1.05
Gamma-aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling. Endocrinology (2009) 1.05
Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides (2008) 1.04
Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior. Front Behav Neurosci (2009) 1.04
Sexual differentiation and development of forebrain reproductive circuits. Curr Opin Neurobiol (2010) 1.03
Circadian control of neuroendocrine circuits regulating female reproductive function. Front Endocrinol (Lausanne) (2012) 1.03
Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women. Front Endocrinol (Lausanne) (2011) 1.02
Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction. J Neuroendocrinol (2010) 1.02
Suppression of kisspeptin expression and gonadotropic axis sensitivity following exposure to inhibitory day lengths in female Siberian hamsters. Horm Behav (2007) 1.01
Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol (2009) 1.01
Estrogenic regulation of the GnRH neuron. Front Endocrinol (Lausanne) (2012) 1.00
Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to estradiol positive feedback in middle-aged rats. Neuropharmacology (2009) 1.00
mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol. Mol Cell Endocrinol (2013) 1.00
Serum kisspeptin levels in Korean girls with central precocious puberty. J Korean Med Sci (2011) 0.99
Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. Am J Physiol Endocrinol Metab (2008) 0.99
Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology (2012) 0.99
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
The dorsomedial suprachiasmatic nucleus times circadian expression of Kiss1 and the luteinizing hormone surge. Endocrinology (2012) 0.98
Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci (2013) 0.98
Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action. J Physiol (2006) 0.97
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty. Front Endocrinol (Lausanne) (2012) 0.97
Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. Br J Pharmacol (2009) 0.97
New understandings of the genetic basis of isolated idiopathic central hypogonadism. Asian J Androl (2011) 0.96
KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology (2011) 0.95
International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol Rev (2010) 0.95
The role of kisspeptin and RFamide-related peptide-3 neurones in the circadian-timed preovulatory luteinising hormone surge. J Neuroendocrinol (2012) 0.95
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol (2013) 0.94
Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons. Endocrinology (2014) 0.94
Photic and nonphotic seasonal cues differentially engage hypothalamic kisspeptin and RFamide-related peptide mRNA expression in Siberian hamsters. J Neuroendocrinol (2009) 0.93
Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology (2012) 0.93
Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones. J Neuroendocrinol (2010) 0.93
Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges. Endocrinology (2008) 0.92
Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction? Proc Biol Sci (2008) 0.92
Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells. J Neuroendocrinol (2011) 0.92
Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev (2008) 0.91
Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat Rev Endocrinol (2013) 0.91
Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol (2013) 0.91
LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.90
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology (2014) 0.90
Photoperiod and testosterone interact to drive seasonal changes in kisspeptin expression in Siberian hamsters (Phodopus sungorus). J Neuroendocrinol (2008) 0.90
Leptin as a modulator of neuroendocrine function in humans. Yonsei Med J (2012) 0.90
PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction. Front Endocrinol (Lausanne) (2012) 0.90
Kisspeptin neurons from mice to men: similarities and differences. Endocrinology (2012) 0.90
Exogenous kisspeptin does not alter photoperiod-induced gonadal regression in Siberian hamsters (Phodopus sungorus). Gen Comp Endocrinol (2008) 0.89
Kisspeptin excitation of GnRH neurons. Adv Exp Med Biol (2013) 0.89
A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10. Am J Physiol Endocrinol Metab (2009) 0.89
Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. J Neuroendocrinol (2013) 0.89
Development of gonadotropin-releasing hormone secretion and pituitary response. J Neurosci (2014) 0.89
Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy. J Clin Endocrinol Metab (2015) 0.88
Sense and nonsense in metabolic control of reproduction. Front Endocrinol (Lausanne) (2012) 0.87
Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain. Front Endocrinol (Lausanne) (2012) 0.87
Daily changes in GT1-7 cell sensitivity to GnRH secretagogues that trigger ovulation. Neuroendocrinology (2009) 0.87
Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology (2005) 4.48
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci (2005) 4.04
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology (2007) 2.57
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology (2005) 2.50
Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci (2006) 2.42
Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology (2007) 2.20
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet (2006) 1.93
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab (2010) 1.76
Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology (2011) 1.75
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology (2005) 1.75
The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci (2007) 1.69
Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest (2014) 1.61
Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav (2006) 1.60
The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol (2008) 1.53
Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism. Endocrinology (2003) 1.52
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci (2007) 1.43
Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci (2009) 1.41
The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci (2007) 1.41
Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab (2009) 1.40
Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology (2009) 1.39
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction (2006) 1.32
Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology (2008) 1.28
Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology (2002) 1.23
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Reliability, validity, and responsiveness of a modified International Knee Documentation Committee Subjective Knee Form (Pedi-IKDC) in children with knee disorders. Am J Sports Med (2010) 1.17
Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology (2010) 1.15
Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci (2012) 1.13
Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinology (2007) 1.10
A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology (2003) 1.10
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2003) 1.07
Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Horm Behav (2005) 1.07
Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology (2009) 1.06
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology (2012) 1.02
Kisspeptin and seasonality in sheep. Peptides (2008) 1.02
Transphyseal anterior cruciate ligament reconstruction in skeletally immature pubescent adolescents. J Bone Joint Surg Am (2007) 1.00
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2). Mol Cell Biol (2005) 0.98
Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology (2004) 0.97
Proteolytic mechanisms in the ovulatory folliculo-luteal transformation. Connect Tissue Res (2003) 0.92
Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab (2004) 0.91
Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin. Endocrinology (2003) 0.89
Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology (2003) 0.89
Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab (2013) 0.89
Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes (2005) 0.89
Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology (2012) 0.88
Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. Diabetes (2004) 0.88