Published in Endocrinology on May 26, 2005
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A (2007) 2.66
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology (2010) 2.23
Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology (2007) 1.98
An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology (2008) 1.76
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab (2010) 1.76
Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology (2011) 1.75
Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology (2008) 1.63
Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology (2011) 1.55
Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides (2008) 1.54
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49
Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience (2010) 1.49
Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology (2010) 1.47
Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology (2015) 1.45
Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology (2009) 1.44
Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One (2009) 1.42
Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci (2009) 1.41
Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab (2009) 1.40
Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology (2009) 1.39
Advances in male contraception. Endocr Rev (2008) 1.39
The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. Endocr Rev (2010) 1.37
Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology (2011) 1.31
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Neuroscience (2009) 1.28
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol (2011) 1.17
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol (2011) 1.17
Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol (2010) 1.17
Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One (2010) 1.17
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology (2012) 1.16
Excitatory effects of the puberty-initiating peptide kisspeptin and group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin-releasing hormone neurons. J Neurosci (2008) 1.16
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and Kiss1 in neonatal male and female rats. J Comp Neurol (2011) 1.14
Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology (2011) 1.14
The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update (2014) 1.13
Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology (2008) 1.13
Kisspeptin and GPR54: discovery of a novel pathway in reproduction. J Neuroendocrinol (2008) 1.12
BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology (2010) 1.12
GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J (2009) 1.12
Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat. Endocrinology (2008) 1.12
Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. Neurotoxicology (2009) 1.11
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol (2007) 1.11
Diurnal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing hormone neurons. J Neurosci (2010) 1.09
Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys. Peptides (2008) 1.09
Anatomy of the kisspeptin neural network in mammals. Brain Res (2010) 1.09
New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons. Front Endocrinol (Lausanne) (2012) 1.09
Analysis of multiple positive feedback paradigms demonstrates a complete absence of LH surges and GnRH activation in mice lacking kisspeptin signaling. Biol Reprod (2013) 1.06
Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology (2010) 1.06
Driving reproduction: RFamide peptides behind the wheel. Horm Behav (2006) 1.06
Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol (2014) 1.05
Gamma-aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling. Endocrinology (2009) 1.05
Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides (2008) 1.04
Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol Reprod (2010) 1.03
Circadian control of neuroendocrine circuits regulating female reproductive function. Front Endocrinol (Lausanne) (2012) 1.03
Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in an estradiol-dependent manner. Endocrinology (2009) 1.03
Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women. Front Endocrinol (Lausanne) (2011) 1.02
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology (2012) 1.02
Kisspeptin and KISS1R: a critical pathway in the reproductive system. Reproduction (2008) 1.01
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques. Endocrinology (2010) 1.01
Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol (2009) 1.01
Estrogenic regulation of the GnRH neuron. Front Endocrinol (Lausanne) (2012) 1.00
Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to estradiol positive feedback in middle-aged rats. Neuropharmacology (2009) 1.00
Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus. Neurotoxicology (2011) 1.00
Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology (2012) 0.99
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
Neuroendocrine consequences of androgen excess in female rodents. Horm Behav (2008) 0.98
Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci (2013) 0.98
Insulin-like growth factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt: effect of alcohol. Neuroscience (2009) 0.97
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty. Front Endocrinol (Lausanne) (2012) 0.97
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol (2013) 0.97
Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proc Natl Acad Sci U S A (2012) 0.96
Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland. Environ Health Perspect (2009) 0.96
Neurobiological mechanisms underlying oestradiol negative and positive feedback regulation of gonadotrophin-releasing hormone neurones. J Neuroendocrinol (2009) 0.95
Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology (2011) 0.95
Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proc Natl Acad Sci U S A (2012) 0.95
International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol Rev (2010) 0.95
The role of kisspeptin and RFamide-related peptide-3 neurones in the circadian-timed preovulatory luteinising hormone surge. J Neuroendocrinol (2012) 0.95
Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice. Endocrinology (2013) 0.95
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol (2013) 0.94
Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons. Endocrinology (2014) 0.94
Membrane-initiated actions of estradiol that regulate reproduction, energy balance and body temperature. Front Neuroendocrinol (2012) 0.93
Photic and nonphotic seasonal cues differentially engage hypothalamic kisspeptin and RFamide-related peptide mRNA expression in Siberian hamsters. J Neuroendocrinol (2009) 0.93
Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging. Endocrinology (2010) 0.93
Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones. J Neuroendocrinol (2010) 0.93
Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges. Endocrinology (2008) 0.92
Differential ovarian expression of KiSS-1 and GPR-54 during the estrous cycle and photoperiod induced recrudescence in Siberian hamsters (Phodopus sungorus). Mol Reprod Dev (2009) 0.91
Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. J Physiol (2016) 0.91
Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat Rev Endocrinol (2013) 0.91
Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev (2008) 0.91
Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol (2013) 0.91
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology (2014) 0.90
Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology (2012) 0.90
dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J Reprod Dev (2013) 0.90
Photoperiod and testosterone interact to drive seasonal changes in kisspeptin expression in Siberian hamsters (Phodopus sungorus). J Neuroendocrinol (2008) 0.90
Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. J Neuroendocrinol (2013) 0.89
Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology (2012) 0.89
Estradiol modulates Kiss1 neuronal response to ghrelin. Am J Physiol Endocrinol Metab (2014) 0.89
Short-term alcohol administration alters KiSS-1 gene expression in the reproductive hypothalamus of prepubertal female rats. Alcohol Clin Exp Res (2009) 0.89
Differential effects of hypothalamic IGF-I on gonadotropin releasing hormone neuronal activation during steroid-induced LH surges in young and middle-aged female rats. Endocrinology (2011) 0.89
Kisspeptin excitation of GnRH neurons. Adv Exp Med Biol (2013) 0.89
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci (2005) 4.04
Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology (2005) 3.52
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci (2002) 3.09
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology (2005) 2.50
Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci (2006) 2.42
Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology (2007) 2.20
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci (2006) 1.78
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab (2010) 1.76
Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology (2011) 1.75
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology (2005) 1.75
The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci (2007) 1.69
An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior. Endocrinology (2003) 1.57
The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol (2008) 1.53
Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism. Endocrinology (2003) 1.52
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology (2012) 1.47
Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav (2004) 1.45
Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci (2007) 1.43
The role of Bisphenol A in shaping the brain, epigenome and behavior. Horm Behav (2010) 1.42
Neurobiology of escalated aggression and violence. J Neurosci (2007) 1.41
Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci (2009) 1.41
The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci (2007) 1.41
Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab (2009) 1.40
Sex differences in histone modifications in the neonatal mouse brain. Epigenetics (2009) 1.40
Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology (2009) 1.39
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction (2006) 1.32
A previously uncharacterized role for estrogen receptor beta: defeminization of male brain and behavior. Proc Natl Acad Sci U S A (2005) 1.32
Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice. Eur J Neurosci (2007) 1.26
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice. Horm Behav (2010) 1.24
New roles for estrogen receptor beta in behavior and neuroendocrinology. Front Neuroendocrinol (2006) 1.23
Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology (2002) 1.23
Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice. PLoS One (2011) 1.21
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci (2012) 1.13
Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinology (2007) 1.10
A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology (2003) 1.10
Aggression in male mice lacking functional estrogen receptor alpha. Behav Neurosci (2003) 1.10
Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization. J Neurosci Res (2003) 1.09
Two perspectives on the origin of sex differences in the brain. Ann N Y Acad Sci (2003) 1.08
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2003) 1.07
The androgen receptor is selectively involved in organization of sexually dimorphic social behaviors in mice. Endocrinology (2008) 1.07
Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Horm Behav (2005) 1.07
Sex chromosome complement affects social interactions in mice. Horm Behav (2008) 1.05
Transgenerational effects of prenatal bisphenol A on social recognition. Horm Behav (2013) 1.02
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology (2012) 1.02
Both estrogen receptor-alpha and -beta are required for sexual differentiation of the anteroventral periventricular area in mice. Endocrinology (2005) 1.02
Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area. Dev Neurobiol (2007) 1.01
Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase. J Comp Neurol (2002) 1.01
Estrogen receptor alpha influences socially motivated behaviors. Horm Behav (2002) 1.00
Aggressive behaviors in adult SF-1 knockout mice that are not exposed to gonadal steroids during development. Behav Neurosci (2008) 1.00
A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior. Endocrinology (2004) 0.99
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2). Mol Cell Biol (2005) 0.98
Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology (2004) 0.97
X-chromosome dosage affects male sexual behavior. Horm Behav (2012) 0.96
Of mice and missing data: what we know (and need to learn) about male sexual behavior. Physiol Behav (2004) 0.95
Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behavior. Horm Behav (2003) 0.95
Background matters: the effects of estrogen receptor alpha gene disruption on male sexual behavior are modified by background strain. Horm Behav (2004) 0.95
Diversity of actions of GnRHs mediated by ligand-induced selective signaling. Front Neuroendocrinol (2007) 0.94
Running-induced epigenetic and gene expression changes in the adolescent brain. Int J Dev Neurosci (2012) 0.94
Sex differences in the cerebellum and frontal cortex: roles of estrogen receptor alpha and sex chromosome genes. Neuroendocrinology (2011) 0.93
Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area. Endocrinology (2004) 0.91
Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab (2004) 0.91
Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice. Horm Behav (2009) 0.91
Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones. Endocrinology (2011) 0.90