Published in Cell Microbiol on May 01, 2005
Disease manifestations and pathogenic mechanisms of group a Streptococcus. Clin Microbiol Rev (2014) 2.20
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. J Immunol (2009) 0.91
CD46 Contributes to the severity of group A streptococcal infection. Infect Immun (2008) 0.86
MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease. Clin Vaccine Immunol (2012) 0.82
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CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection. Infect Immun (2009) 0.79
Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet (2015) 0.75
Characterization of CD46 and β1 integrin dynamics during sperm acrosome reaction. Sci Rep (2016) 0.75
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood (2006) 4.51
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol (2009) 3.19
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2006) 2.88
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 2.83
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood (2004) 2.58
Adenovirus type 11 uses CD46 as a cellular receptor. J Virol (2003) 2.52
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology (2005) 2.36
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet (2007) 2.35
T-cell regulation: with complements from innate immunity. Nat Rev Immunol (2006) 2.27
Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly. J Immunol (2007) 2.00
Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog (2007) 1.97
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci U S A (2006) 1.96
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.82
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol (2006) 1.81
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet (2013) 1.77
Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med (2010) 1.76
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol (2010) 1.67
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57
Properdin: emerging roles of a pattern-recognition molecule. Annu Rev Immunol (2010) 1.55
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood (2007) 1.53
Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med (2011) 1.52
Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation. Infect Immun (2007) 1.51
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus. J Immunol (2003) 1.45
Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol (2011) 1.45
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Mol Immunol (2007) 1.42
CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7. J Virol (2005) 1.37
New roles for the major human 3'-5' exonuclease TREX1 in human disease. Cell Cycle (2008) 1.35
CD46: expanding beyond complement regulation. Trends Immunol (2004) 1.32
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell (2002) 1.25
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. J Biol Chem (2001) 1.22
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation. J Immunol (2006) 1.21
Prospects for a group A streptococcal vaccine: rationale, feasibility, and obstacles--report of a National Institute of Allergy and Infectious Diseases workshop. Clin Infect Dis (2005) 1.20
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J Biol Chem (2003) 1.16
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol (2002) 1.14
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection. Proc Natl Acad Sci U S A (2010) 1.12
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2007) 1.12
Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. Infect Immun (2003) 1.11
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells. Cell Microbiol (2006) 1.09
Localization of regions in CD46 that interact with adenovirus. J Virol (2005) 1.08
Primary induction of CD4 T cell responses in nasal associated lymphoid tissue during group A streptococcal infection. Eur J Immunol (2004) 1.07
Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol (2004) 1.07
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol (2005) 1.07
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther (2009) 1.05
Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol (2008) 1.05
Membrane protein Crry maintains homeostasis of the complement system. J Immunol (2008) 1.04
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. J Immunol (2009) 1.03
Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.03
Mutations in CD46, a complement regulatory protein, predispose to atypical HUS. Trends Mol Med (2004) 1.02
The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. J Immunol (2002) 1.02
Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK. Biochem Biophys Res Commun (2006) 1.02
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02
Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest (2005) 1.02
N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology (2011) 1.02
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement. Mol Immunol (2004) 1.00
Structure of the streptococcal cell wall C5a peptidase. Proc Natl Acad Sci U S A (2005) 1.00
Immune response to group A streptococcal C5a peptidase in children: implications for vaccine development. J Infect Dis (2003) 1.00
Human complement receptor type 1 (CR1) binds to a major malarial adhesin. Trends Mol Med (2002) 0.98
Complement-mediated neutralization of dengue virus requires mannose-binding lectin. MBio (2011) 0.97
Oversulfated heparin by-products induce thrombin generation in human plasmas through contact system activation. Clin Appl Thromb Hemost (2010) 0.97
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2012) 0.96
T-cell stimulation and regulation: with complements from CD46. Immunol Res (2005) 0.95
Inhibiting complement activation on cells at the step of C3 cleavage. Vaccine (2008) 0.94
CD46-induced human Treg enhance B-cell responses. Eur J Immunol (2009) 0.94
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol (2013) 0.93
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92
Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment. J Immunol (2008) 0.92
Immunization with C5a peptidase or peptidase-type III polysaccharide conjugate vaccines enhances clearance of group B Streptococci from lungs of infected mice. Infect Immun (2002) 0.90
In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. J Immunol (2005) 0.90
Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. J Clin Invest (2015) 0.90
Down-regulation of CD46 by piliated Neisseria gonorrhoeae. J Exp Med (2003) 0.89
Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol Reprod Dev (2002) 0.89
Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils. Infect Immun (2005) 0.88
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases. J Biol Chem (2003) 0.87
Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. J Immunol (2002) 0.87
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. Genet Med (2012) 0.86
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem (2013) 0.86
The M protein is dispensable for maturation of streptococcal cysteine protease SpeB. Infect Immun (2005) 0.86
The early interferon response of nasal-associated lymphoid tissue to Streptococcus pyogenes infection. FEMS Immunol Med Microbiol (2009) 0.86
Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PLoS One (2012) 0.86
M1 protein triggers a phosphoinositide cascade for group A Streptococcus invasion of epithelial cells. Infect Immun (2003) 0.85
Effect of lipooligosaccharide mutations of Haemophilus influenzae on the middle and inner ears. Int J Pediatr Otorhinolaryngol (2009) 0.85