Published in Mol Cell Biol on May 01, 2005
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab (2009) 3.78
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol (2009) 1.30
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun (2011) 1.28
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem (2009) 1.24
Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release. Front Immunol (2013) 1.07
Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils. PLoS One (2011) 1.06
Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells. Blood (2008) 1.04
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol (2012) 0.99
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. Proc Natl Acad Sci U S A (2010) 0.96
Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway. Mediators Inflamm (2013) 0.93
Identification and validation of a two-gene expression index for subtype classification and prognosis in Diffuse Large B-Cell Lymphoma. Sci Rep (2015) 0.82
LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer. Cancer Sci (2014) 0.82
Proteomic profiling of lipopolysaccharide-activated macrophages by isotope coded affinity tagging. J Proteome Res (2010) 0.79
Genomic Characterization of Metformin Hepatic Response. PLoS Genet (2016) 0.79
The LIM protein LIMD1 influences osteoblast differentiation and function. Exp Cell Res (2008) 0.78
The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction. Cell Death Differ (2015) 0.78
AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression. Oncotarget (2016) 0.77
The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ. Sci Rep (2016) 0.76
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB. Elife (2017) 0.75
AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Mol Cell Biol (2016) 0.75
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response. Sci Rep (2017) 0.75
TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol (2017) 0.75
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell (2003) 5.68
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell (2004) 5.08
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE (2003) 4.14
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol (2003) 3.69
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells (1999) 3.69
The LIM domain: regulation by association. Mech Dev (2000) 3.45
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev (1999) 3.41
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature (1996) 3.26
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell (2001) 3.05
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J (1999) 2.80
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol (1998) 2.35
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. J Biochem (2003) 2.32
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev (1999) 2.17
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A (1997) 2.11
Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett (2002) 2.06
Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol (1997) 2.01
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics (1996) 1.93
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature (2002) 1.80
Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol Biol Cell (2000) 1.79
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc Natl Acad Sci U S A (1996) 1.73
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. J Biol Chem (1999) 1.72
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol (1999) 1.70
Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem (1991) 1.65
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell (2000) 1.62
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem (2001) 1.49
Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. Curr Opin Cell Biol (2002) 1.41
The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol (2002) 1.36
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes. J Biol Chem (1997) 1.26
SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene (1996) 1.21
The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics (1998) 1.19
Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol (2003) 1.18
The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol (2003) 1.12
A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. Hum Genet (1999) 1.08
Interleukin-1beta activates protein kinase C zeta in renal mesangial cells. Potential role in prostaglandin E2 up-regulation. J Biol Chem (1996) 0.97
The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol Cell Neurosci (2002) 0.89
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem (2009) 1.73
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol (2010) 1.73
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res (2011) 1.42
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A (2008) 1.31
The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res (2007) 1.30
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol (2008) 1.21
A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi. Genomics Proteomics Bioinformatics (2010) 1.20
Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol Cell Biol (2007) 1.18
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Sci Rep (2013) 1.13
Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway. Oncogene (2003) 1.10
Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia. J Cell Biol (2009) 1.10
p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res (2009) 1.10
Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J Biol Chem (2008) 1.10
Actin stress fiber pre-extension in human aortic endothelial cells. Cell Motil Cytoskeleton (2008) 1.08
Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain. Ann Biomed Eng (2009) 1.08
The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia. Curr Biol (2010) 1.08
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. J Biol Chem (2006) 1.07
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. FASEB J (2013) 1.07
Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer. Biophys J (2012) 1.03
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A (2010) 1.03
The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol (2005) 1.01
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension. J Cell Biol (2009) 0.99
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol (2012) 0.99
Differential regulation of apoptotic genes by Rb in human versus mouse cells. Oncogene (2004) 0.97
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. Proc Natl Acad Sci U S A (2010) 0.96
Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. Biophys J (2007) 0.95
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proc Natl Acad Sci U S A (2008) 0.93
Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members. Oncogene (2004) 0.91
Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. Nucleic Acids Res (2013) 0.90
CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells. J Immunol (2008) 0.89
The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol Cell Neurosci (2002) 0.89
Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms. J Clin Oncol (2009) 0.87
α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation. Exp Cell Res (2013) 0.83
Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. Ann Biomed Eng (2010) 0.80
Ras protects Rb family null fibroblasts from cell death: a role for AP-1. J Biol Chem (2003) 0.80
The LIM protein LIMD1 influences osteoblast differentiation and function. Exp Cell Res (2008) 0.78
Effects of recombinant hematopoietins on blood-loss anemia in mice. Iowa Orthop J (2005) 0.77
β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. Biophys J (2013) 0.77
Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. Int J Cancer (2008) 0.77
Context-dependent compensatory proliferation in epithelial homeostasis and tumorigenesis. Cell Cycle (2010) 0.75
Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (2016) 0.75