Published in J Biol Chem on November 08, 2006
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30
Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J Biol Chem (2008) 1.10
Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils. PLoS One (2011) 1.06
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell (2012) 1.05
Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts. J Biol Chem (2008) 0.95
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proc Natl Acad Sci U S A (2008) 0.93
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One (2011) 0.92
Identification and validation of a two-gene expression index for subtype classification and prognosis in Diffuse Large B-Cell Lymphoma. Sci Rep (2015) 0.82
The LIM protein LIMD1 influences osteoblast differentiation and function. Exp Cell Res (2008) 0.78
PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Lett (2011) 0.77
Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1). Oncotarget (2016) 0.76
AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Mol Cell Biol (2016) 0.75
Genetic regulation of osteoclast development and function. Nat Rev Genet (2003) 7.94
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev (2008) 5.28
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest (2005) 3.56
Osteopetrosis. N Engl J Med (2004) 2.95
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
The osteoclast: friend or foe? Annu Rev Pathol (2008) 2.45
Vav3 regulates osteoclast function and bone mass. Nat Med (2005) 2.30
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis. J Exp Med (2003) 2.20
c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. J Clin Invest (2003) 2.19
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest (2006) 2.11
Depression, antidepressants, and bone health in older adults: a systematic review. J Am Geriatr Soc (2014) 2.08
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood (2010) 1.98
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype. J Cell Biochem (2003) 1.87
alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol Rev (2005) 1.81
Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem (2013) 1.80
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol (2010) 1.79
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem (2009) 1.73
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol (2010) 1.73
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med (2002) 1.71
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest (2010) 1.71
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci U S A (2008) 1.68
Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin. J Cell Biol (2003) 1.65
M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest (2005) 1.64
Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem (2001) 1.55
RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest (2008) 1.52
Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell (2006) 1.52
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell (2008) 1.52
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol (2004) 1.50
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J Clin Invest (2004) 1.45
Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A (2009) 1.44
Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res (2011) 1.42
Animal rights pressure on scientists. Science (2002) 1.39
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell (2008) 1.38
Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res (2006) 1.35
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A (2008) 1.31
The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res (2007) 1.30
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. J Immunol (2012) 1.30
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol (2005) 1.28
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
The Interplay between the bone and the immune system. Clin Dev Immunol (2013) 1.26
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood (2007) 1.22
Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis. J Immunol (2003) 1.21
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol (2008) 1.21
A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi. Genomics Proteomics Bioinformatics (2010) 1.20
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res (2009) 1.19
Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol Cell Biol (2007) 1.18
Critical role of beta3 integrin in experimental postmenopausal osteoporosis. J Bone Miner Res (2005) 1.17
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake. Traffic (2003) 1.14
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Sci Rep (2013) 1.13