Published in Chembiochem on July 01, 2005
Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol (2006) 2.29
Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry (2011) 1.18
Analysis of myxobacterial secondary metabolism goes molecular. J Ind Microbiol Biotechnol (2006) 1.15
Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. Biochemistry (2010) 1.07
Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface (2013) 0.99
Type I polyketide synthases that require discrete acyltransferases. Methods Enzymol (2009) 0.99
Microtubule binding and disruption and induction of premature senescence by disorazole C(1). J Pharmacol Exp Ther (2008) 0.96
Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides. Nat Prod Rep (2009) 0.93
Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449. Appl Environ Microbiol (2009) 0.90
Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1. J Pharmacol Exp Ther (2009) 0.87
PCR detection of type I polyketide synthase genes in myxobacteria. Appl Environ Microbiol (2008) 0.87
Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. Biochemistry (2014) 0.85
Structural analysis of protein-protein interactions in type I polyketide synthases. Crit Rev Biochem Mol Biol (2012) 0.85
Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2. Microb Cell Fact (2009) 0.77
Portability and Structure of the Four-Helix Bundle Docking Domains of trans-Acyltransferase Modular Polyketide Synthases. ACS Chem Biol (2016) 0.77
Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering. Sci Rep (2016) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
GeneTrail--advanced gene set enrichment analysis. Nucleic Acids Res (2007) 5.10
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol (2012) 2.54
Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 2.43
Ear deformations give bats a physical mechanism for fast adaptation of ultrasonic beam patterns. Phys Rev Lett (2011) 2.22
Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol (2005) 2.06
The sensitivity of polar ozone depletion to proposed geoengineering schemes. Science (2008) 2.05
The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea. ISME J (2009) 2.00
The RNA polymerase "switch region" is a target for inhibitors. Cell (2008) 1.96
Opening and closing of the bacterial RNA polymerase clamp. Science (2012) 1.73
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase. EMBO J (2005) 1.71
The impact of bacterial genomics on natural product research. Angew Chem Int Ed Engl (2005) 1.70
Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Chem Biol (2006) 1.56
Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic. Curr Opin Chem Biol (2005) 1.51
Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases. Chembiochem (2006) 1.46
Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium. J Biotechnol (2003) 1.44
Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines. J Bacteriol (2005) 1.43
Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity. Appl Environ Microbiol (2008) 1.40
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39
Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol (2005) 1.36
Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem (2004) 1.35
Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications. Angew Chem Int Ed Engl (2008) 1.32
The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell (2003) 1.30
Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse. Int J Cancer (2013) 1.27
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene (2004) 1.27
Noseleaf furrows in a horseshoe bat act as resonance cavities shaping the biosonar beam. Phys Rev Lett (2006) 1.27
New target for inhibition of bacterial RNA polymerase: 'switch region'. Curr Opin Microbiol (2011) 1.26
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24
The impact of genomics on the exploitation of the myxobacterial secondary metabolome. Nat Prod Rep (2009) 1.23
Myxobacterial secondary metabolites: bioactivities and modes-of-action. Nat Prod Rep (2010) 1.23
Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). PLoS One (2011) 1.23
Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2. Blood (2003) 1.22
The biosynthetic potential of myxobacteria and their impact in drug discovery. Curr Opin Drug Discov Devel (2009) 1.22
Diversity and evolution of repABC type plasmids in Rhodobacterales. Environ Microbiol (2009) 1.21
Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol Microbiol (2003) 1.20
Bacteria of the Roseobacter clade show potential for secondary metabolite production. Microb Ecol (2007) 1.20
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites. Mol Biosyst (2009) 1.19
Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering. Chem Biol (2005) 1.18
Comparative genomic analysis of fruiting body formation in Myxococcales. Mol Biol Evol (2010) 1.17
Biosynthesis of the off-flavor 2-methylisoborneol by the myxobacterium Nannocystis exedens. Angew Chem Int Ed Engl (2007) 1.16
Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Nat Prod Rep (2013) 1.16
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. Proc Natl Acad Sci U S A (2008) 1.16
Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol (2007) 1.16
Protein-protein interactions in multienzyme megasynthetases. Chembiochem (2008) 1.16
The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation. Proc Natl Acad Sci U S A (2006) 1.15
Analysis of myxobacterial secondary metabolism goes molecular. J Ind Microbiol Biotechnol (2006) 1.15
Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis. Chem Biol (2012) 1.14
Extrachromosomal, extraordinary and essential--the plasmids of the Roseobacter clade. Appl Microbiol Biotechnol (2013) 1.13
Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol (2004) 1.12
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res (2010) 1.12
Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. J Am Chem Soc (2008) 1.11
Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition. Nucleic Acids Res (2008) 1.11
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One (2012) 1.11
Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A-F and analogues. Chemistry (2009) 1.11
The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase. J Biol Chem (2002) 1.11
A novel type of geosmin biosynthesis in myxobacteria. J Org Chem (2005) 1.10
Numerical study of the effect of the noseleaf on biosonar beamforming in a horseshoe bat. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.10
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife (2014) 1.09
Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells. Protein Eng Des Sel (2004) 1.08
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1. Cancer Res (2012) 1.08
In vivo evidence for a prodrug activation mechanism during colibactin maturation. Chembiochem (2013) 1.08
Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol (2004) 1.07
Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene (2005) 1.07
Origin and evolution of a novel DnaA-like plasmid replication type in Rhodobacterales. Mol Biol Evol (2010) 1.07
15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist. Mol Pharmacol (2009) 1.05
Molecular and phenotypic analyses reveal the non-identity of the Phaeobacter gallaeciensis type strain deposits CIP 105210T and DSM 17395. Int J Syst Evol Microbiol (2013) 1.05
Nonribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversity. Angew Chem Int Ed Engl (2006) 1.04
Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription. J Biol Chem (2010) 1.04
Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases. Chem Biol (2003) 1.04
3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation. J Bacteriol (2006) 1.03
Biosynthesis and identification of volatiles released by the myxobacterium Stigmatella aurantiaca. Chembiochem (2005) 1.03
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol (2010) 1.02
Improved seamless mutagenesis by recombineering using ccdB for counterselection. Nucleic Acids Res (2013) 1.01
Time to retire--time to die? A prospective cohort study of the effects of early retirement on long-term survival. Soc Sci Med (2009) 1.01
Unusual carbon fixation gives rise to diverse polyketide extender units. Nat Chem Biol (2011) 1.01
Biosynthesis of the myxobacterial antibiotic corallopyronin A. Chembiochem (2010) 1.01
A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. Chembiochem (2005) 1.01
Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity. Angew Chem Int Ed Engl (2014) 1.00
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles. Genome Biol (2005) 1.00
Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones. Chembiochem (2007) 0.99
Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum. J Am Chem Soc (2008) 0.98
Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionisation-time-of-flight mass spectrometry and compound-based principal component analysis. Anal Chim Acta (2008) 0.98
Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) beta/delta: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid. Mol Pharmacol (2008) 0.98
Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthus. Chembiochem (2009) 0.97
Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate. J Am Chem Soc (2002) 0.97
Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity. J Antibiot (Tokyo) (2005) 0.97
Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res (2012) 0.96
Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosa. Chembiochem (2012) 0.96
A brief tour of myxobacterial secondary metabolism. Bioorg Med Chem (2008) 0.96
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin. Chembiochem (2007) 0.95
De novo peptide sequencing by tandem MS using complementary CID and electron transfer dissociation. Electrophoresis (2009) 0.95
From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes. J Mol Biol (2007) 0.95
Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus. Appl Environ Microbiol (2006) 0.95
Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering. Chembiochem (2012) 0.95
Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads. Arch Microbiol (2006) 0.95
Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry. Nat Prod Rep (2007) 0.95