The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 329405)

Published in Mol Biol Cell on October 31, 2003

Authors

Angelika A Noegel1, Rosemarie Blau-Wasser, Hameeda Sultana, Rolf Müller, Lars Israel, Michael Schleicher, Hitesh Patel, Cornelis J Weijer

Author Affiliations

1: Center for Biochemistry, Medical Faculty, University of Cologne, 50931 Cologne, Germany.

Articles citing this

Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Mol Biol Cell (2005) 2.15

Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol Biol Cell (2004) 1.61

A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein. Mol Biol Cell (2004) 1.18

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin. Mol Biol Cell (2012) 1.14

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism. Exp Cell Res (2008) 0.99

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. J Cell Biol (2008) 0.98

The role of cyclase-associated protein in regulating actin filament dynamics - more than a monomer-sequestration factor. J Cell Sci (2013) 0.97

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I. PLoS One (2010) 0.94

Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism. J Biol Chem (2012) 0.92

UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex. PLoS Genet (2012) 0.88

Cytoskeletal interactions at the nuclear envelope mediated by nesprins. Int J Cell Biol (2012) 0.87

Expression of recombinant streptokinase from streptococcus pyogenes and its reaction with infected human and murine sera. Iran J Basic Med Sci (2013) 0.85

Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains. PLoS One (2012) 0.82

CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope. Mol Biol Cell (2009) 0.82

GxcDD, a putative RacGEF, is involved in Dictyostelium development. BMC Cell Biol (2007) 0.82

A Coronin7 homolog with functions in actin-driven processes. J Biol Chem (2010) 0.81

A cytohesin homolog in Dictyostelium amoebae. PLoS One (2010) 0.81

Mammalian CAP (Cyclase-associated protein) in the world of cell migration: Roles in actin filament dynamics and beyond. Cell Adh Migr (2013) 0.80

Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum. BMC Cell Biol (2007) 0.80

CRN2 enhances the invasiveness of glioblastoma cells. Neuro Oncol (2013) 0.79

The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility. Cell Commun Signal (2013) 0.79

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biol (2015) 0.78

CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation. Int J Mol Med (2015) 0.78

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity. PLoS One (2014) 0.78

The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway. Cell Cycle (2015) 0.78

The Dictyostelium discoideum RACK1 orthologue has roles in growth and development. Cell Commun Signal (2014) 0.77

Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins. Sci Rep (2015) 0.77

Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer (2015) 0.77

Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells. BMC Dev Biol (2012) 0.76

The C-Terminal SynMuv/DdDUF926 Domain Regulates the Function of the N-Terminal Domain of DdNKAP. PLoS One (2016) 0.75

The Dictyostelium discoideum GPHR ortholog is an endoplasmic reticulum and Golgi protein with roles during development. Eukaryot Cell (2014) 0.75

CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genomics (2016) 0.75

A Tripeptidyl peptidase 1 is a binding partner of GPHR (Golgi pH regulator) in Dictyostelium. Dis Model Mech (2017) 0.75

Articles cited by this

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20

G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60

Adaptation of core mechanisms to generate cell polarity. Nature (2003) 5.64

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34

DNA-mediated transformation in Dictyostelium discoideum: regulated expression of an actin gene fusion. Mol Cell Biol (1984) 3.37

Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell (1992) 2.60

Microfilament dynamics during cell movement and chemotaxis monitored using a GFP-actin fusion protein. Curr Biol (1997) 2.57

SRV2, a gene required for RAS activation of adenylate cyclase in yeast. Cell (1990) 2.41

Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell (1990) 2.41

Chemotactic reorientation of granulocytes stimulated with micropipettes containing fMet-Leu-Phe. J Cell Sci (1981) 2.12

Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell (1994) 2.10

End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Mol Biol Cell (1997) 2.07

The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays (2000) 2.02

CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol (1994) 1.96

Chemoattractant-controlled accumulation of coronin at the leading edge of Dictyostelium cells monitored using a green fluorescent protein-coronin fusion protein. Curr Biol (1995) 1.95

Evidence for physical and functional interactions among two Saccharomyces cerevisiae SH3 domain proteins, an adenylyl cyclase-associated protein and the actin cytoskeleton. Mol Biol Cell (1997) 1.94

PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J Cell Biol (1999) 1.89

The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr Biol (1996) 1.86

An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein. J Biol Chem (1995) 1.83

A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev (1997) 1.82

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol (1995) 1.77

Carbohydrate and other epitopes of the contact site A glycoprotein of Dictyostelium discoideum as characterized by monoclonal antibodies. Cell Differ (1985) 1.71

A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells. Cell Motil Cytoskeleton (1998) 1.66

Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J Cell Sci (2002) 1.63

Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors. J Cell Biol (2003) 1.62

Complete sequence and transcript regulation of a cell adhesion protein from aggregating Dictyostelium cells. EMBO J (1986) 1.55

Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. FASEB J (2002) 1.53

Monoclonal antibodies prepared against Dictyostelium actin: characterization and interactions with actin. J Cell Biol (1984) 1.46

PI 3-kinases and PTEN: how opposites chemoattract. Cell (2002) 1.46

Signaling through chemoattractant receptors in Dictyostelium. Trends Genet (1996) 1.40

Changes in actin associated with the cytoskeleton following chemotactic stimulation of dictyostelium discoideum. Biochem Biophys Res Commun (1983) 1.35

act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc. Cell (2000) 1.33

A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol (2000) 1.24

Dictyostelium: a model for regulated cell movement during morphogenesis. Curr Opin Genet Dev (2000) 1.22

Profilin, a weak CAP for actin and RAS. Cell (1991) 1.21

Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin. Mol Biol Cell (1996) 1.16

Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J Biol Chem (1995) 1.15

Assessing the role of the ASP56/CAP homologue of Dictyostelium discoideum and the requirements for subcellular localization. J Cell Sci (1999) 1.13

A novel adenylyl cyclase detected in rapidly developing mutants of Dictyostelium. J Biol Chem (1998) 1.12

The control of chemotactic cell movement during Dictyostelium morphogenesis. Philos Trans R Soc Lond B Biol Sci (2000) 1.03

Dictyostelium RasD is required for normal phototaxis, but not differentiation. Genes Dev (2000) 1.02

Molecular cloning and characterization of DdCAD-1, a Ca2+-dependent cell-cell adhesion molecule, in Dictyostelium discoideum. J Biol Chem (1996) 1.01

Evidence that cyclic GMP regulates myosin interaction with the cytoskeleton during chemotaxis of Dictyostelium. J Cell Sci (1988) 1.01

Twisted scroll waves organize Dictyostelium mucoroides slugs. J Cell Sci (1997) 1.00

Constitutive overexpression of the contact site A glycoprotein enables growth-phase cells of Dictyostelium discoideum to aggregate. EMBO J (1990) 0.97

Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the F-actin cross-linking gelation factor (ABP-120). Curr Biol (1997) 0.96

Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with adenylyl cyclase is sufficient for its function in Saccharomyces cerevisiae ras pathway. J Biol Chem (1998) 0.95

Spontaneous turning behaviour by Dictyostelium discoideum slugs. J Cell Sci (1983) 0.89

cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium. J Cell Sci (2001) 0.89

Light affects cAMP signaling and cell movement activity in Dictyostelium discoideum. Proc Natl Acad Sci U S A (2000) 0.89

Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. Structure (2003) 0.89

A temperature-sensitive adenylyl cyclase mutant of Dictyostelium. EMBO J (2000) 0.87

Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein. Mol Biol Cell (1999) 0.83

Articles by these authors

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

GeneTrail--advanced gene set enrichment analysis. Nucleic Acids Res (2007) 5.10

RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93

Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci (2006) 2.79

Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell (2009) 2.61

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol (2012) 2.54

The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia. Nat Cell Biol (2005) 2.47

Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 2.43

A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res (2004) 2.31

The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol (2010) 2.23

Ear deformations give bats a physical mechanism for fast adaptation of ultrasonic beam patterns. Phys Rev Lett (2011) 2.22

Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19

A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12

Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol (2005) 2.06

The sensitivity of polar ozone depletion to proposed geoengineering schemes. Science (2008) 2.05

Collaborative development of predictive toxicology applications. J Cheminform (2010) 1.91

OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell (2007) 1.87

Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell (2005) 1.73

The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci U S A (2006) 1.72

The impact of bacterial genomics on natural product research. Angew Chem Int Ed Engl (2005) 1.70

Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol (2004) 1.63

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62

Detection of myocardial scar by contrast-enhanced cardiac magnetic resonance imaging in patients with troponin-positive chest pain and minimal angiographic coronary artery disease. Am J Cardiol (2006) 1.60

Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Chem Biol (2006) 1.56

Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res (2011) 1.53

In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J Cell Sci (2004) 1.51

Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic. Curr Opin Chem Biol (2005) 1.51

Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases. Chembiochem (2006) 1.46

Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium. J Biotechnol (2003) 1.44

Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines. J Bacteriol (2005) 1.43

Simultaneous quantification of cell motility and protein-membrane-association using active contours. Cell Motil Cytoskeleton (2002) 1.42

Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity. Appl Environ Microbiol (2008) 1.40

Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36

Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol (2005) 1.36

Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space. J Biol Chem (2007) 1.35

Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem (2004) 1.35

Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications. Angew Chem Int Ed Engl (2008) 1.32

Practical aspects of the 2D 15N-[1h]-NOE experiment. J Biomol NMR (2002) 1.29

Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution. Proc Natl Acad Sci U S A (2008) 1.28

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse. Int J Cancer (2013) 1.27

Noseleaf furrows in a horseshoe bat act as resonance cavities shaping the biosonar beam. Phys Rev Lett (2006) 1.27

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene (2004) 1.27

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27

Imaging of cell migration. EMBO J (2006) 1.26

Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24

The impact of genomics on the exploitation of the myxobacterial secondary metabolome. Nat Prod Rep (2009) 1.23

Myxobacterial secondary metabolites: bioactivities and modes-of-action. Nat Prod Rep (2010) 1.23

Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). PLoS One (2011) 1.23

Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2. Blood (2003) 1.22

The biosynthetic potential of myxobacteria and their impact in drug discovery. Curr Opin Drug Discov Devel (2009) 1.22

Dictyostelium transcriptional host cell response upon infection with Legionella. Cell Microbiol (2006) 1.22

Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21

PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development (2008) 1.21

The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments. EMBO Rep (2005) 1.21

Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. J Clin Invest (2010) 1.21

Phospholipids regulate localization and activity of mDia1 formin. Eur J Cell Biol (2010) 1.20

Bacteria of the Roseobacter clade show potential for secondary metabolite production. Microb Ecol (2007) 1.20

Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol Microbiol (2003) 1.20

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19

Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites. Mol Biosyst (2009) 1.19

High-resolution dissection of phagosome maturation reveals distinct membrane trafficking phases. Mol Biol Cell (2002) 1.18

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering. Chem Biol (2005) 1.18

Cell movement during chick primitive streak formation. Dev Biol (2006) 1.17

Comparative genomic analysis of fruiting body formation in Myxococcales. Mol Biol Evol (2010) 1.17

Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development. J Cell Sci (2005) 1.17

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Nat Prod Rep (2013) 1.16

Biosynthesis of the off-flavor 2-methylisoborneol by the myxobacterium Nannocystis exedens. Angew Chem Int Ed Engl (2007) 1.16

Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol (2007) 1.16

Protein-protein interactions in multienzyme megasynthetases. Chembiochem (2008) 1.16

Analysis of tissue flow patterns during primitive streak formation in the chick embryo. Dev Biol (2005) 1.15

The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation. Proc Natl Acad Sci U S A (2006) 1.15

Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum. Int J Med Microbiol (2002) 1.15

Analysis of myxobacterial secondary metabolism goes molecular. J Ind Microbiol Biotechnol (2006) 1.15

Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes. Chembiochem (2005) 1.15

Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin. J Biol Chem (2003) 1.14

Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis. Chem Biol (2012) 1.14

Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol (2011) 1.12

Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol (2004) 1.12

Chemotactic cell movement during Dictyostelium development and gastrulation. Curr Opin Genet Dev (2006) 1.11

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition. Nucleic Acids Res (2008) 1.11

Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. J Am Chem Soc (2008) 1.11

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One (2012) 1.11

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase. J Biol Chem (2002) 1.11

Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A-F and analogues. Chemistry (2009) 1.11

Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem (2010) 1.11

A novel type of geosmin biosynthesis in myxobacteria. J Org Chem (2005) 1.10

Numerical study of the effect of the noseleaf on biosonar beamforming in a horseshoe bat. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.10

The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes. EMBO J (2011) 1.09

Chemotactic cell movement during development. Curr Opin Genet Dev (2003) 1.08

Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. J Cell Biol (2010) 1.08

Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay. J Clin Microbiol (2011) 1.08

Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells. Protein Eng Des Sel (2004) 1.08

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1. Cancer Res (2012) 1.08

In vivo evidence for a prodrug activation mechanism during colibactin maturation. Chembiochem (2013) 1.08

Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol (2004) 1.07

Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene (2005) 1.07

15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist. Mol Pharmacol (2009) 1.05

Nonribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversity. Angew Chem Int Ed Engl (2006) 1.04