Published in Bioconjug Chem on May 18, 2005
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Altering amine basicities in biodegradable branched polycationic polymers for nonviral gene delivery. Biomacromolecules (2010) 0.81
Biodegradable branched polycationic polymers with varying hydrophilic spacers for nonviral gene delivery. Biomacromolecules (2009) 0.80
Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. Biomaterials (2010) 0.80
Virus-inspired approach to nonviral gene delivery vehicles. Biomacromolecules (2009) 0.78
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
Mimicry of antimicrobial host-defense peptides by random copolymers. J Am Chem Soc (2007) 2.12
Foldamers with heterogeneous backbones. Acc Chem Res (2008) 1.96
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87
Copper-catalyzed aerobic oxidative C-H functionalizations: trends and mechanistic insights. Angew Chem Int Ed Engl (2011) 1.79
Palladium(II)-catalyzed alkene functionalization via nucleopalladation: stereochemical pathways and enantioselective catalytic applications. Chem Rev (2011) 1.76
Highly regioselective Pd-catalyzed intermolecular aminoacetoxylation of alkenes and evidence for cis-aminopalladation and S(N)2 C-O bond formation. J Am Chem Soc (2006) 1.69
Targeting protein-protein interactions: lessons from p53/MDM2. Biopolymers (2007) 1.67
Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides. J Am Chem Soc (2002) 1.66
Highly practical copper(I)/TEMPO catalyst system for chemoselective aerobic oxidation of primary alcohols. J Am Chem Soc (2011) 1.64
Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem (2003) 1.57
(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. J Am Chem Soc (2007) 1.56
Translocation of a beta-peptide across cell membranes. J Am Chem Soc (2002) 1.55
Helix bundle quaternary structure from alpha/beta-peptide foldamers. J Am Chem Soc (2007) 1.54
Synthesis of pyrrolidines via palladium(II)-catalyzed aerobic oxidative carboamination of butyl vinyl ether and styrenes with allyl tosylamides. Org Lett (2006) 1.50
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Copper-catalyzed aerobic oxidative amidation of terminal alkynes: efficient synthesis of ynamides. J Am Chem Soc (2008) 1.48
Palladium-catalyzed aerobic oxidative amination of alkenes: development of intra- and intermolecular aza-Wacker reactions. Inorg Chem (2007) 1.43
Carbon-nitrogen bond formation involving well-defined aryl-copper(III) complexes. J Am Chem Soc (2008) 1.40
Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of alpha/beta-peptides. J Am Chem Soc (2007) 1.40
Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones. J Am Chem Soc (2011) 1.39
Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc (2005) 1.39
Copper-catalyzed aerobic oxidative functionalization of an arene C-H bond: evidence for an aryl-copper(III) intermediate. J Am Chem Soc (2010) 1.38
Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. J Mol Biol (2008) 1.37
Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains. Angew Chem Int Ed Engl (2008) 1.35
Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc Natl Acad Sci U S A (2008) 1.35
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Mechanistic study of copper-catalyzed aerobic oxidative coupling of arylboronic esters and methanol: insights into an organometallic oxidase reaction. J Am Chem Soc (2009) 1.34
Mechanism of Pd(OAc)2/DMSO-catalyzed aerobic alcohol oxidation: mass-transfer-limitation effects and catalyst decomposition pathways. J Am Chem Soc (2006) 1.33
Efficient intramolecular oxidative amination of olefins through direct dioxygen-coupled palladium catalysis. Angew Chem Int Ed Engl (2002) 1.32
Rational development of beta-peptide inhibitors of human cytomegalovirus entry. J Biol Chem (2005) 1.32
Two-faced reactivity of alkenes: cis- versus trans-aminopalladation in aerobic Pd-catalyzed intramolecular aza-Wacker reactions. J Am Chem Soc (2007) 1.31
Development of Safe and Scalable Continuous-Flow Methods for Palladium-Catalyzed Aerobic Oxidation Reactions. Green Chem (2010) 1.29
Allylic C-H acetoxylation with a 4,5-diazafluorenone-ligated palladium catalyst: a ligand-based strategy to achieve aerobic catalytic turnover. J Am Chem Soc (2010) 1.29
Structure-activity studies of 14-helical antimicrobial beta-peptides: probing the relationship between conformational stability and antimicrobial potency. J Am Chem Soc (2002) 1.27
Structure-activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides. J Am Chem Soc (2009) 1.26
Preferred side-chain constellations at antiparallel coiled-coil interfaces. Proc Natl Acad Sci U S A (2008) 1.26
Overcoming the "oxidant problem": strategies to use O2 as the oxidant in organometallic C-H oxidation reactions catalyzed by Pd (and Cu). Acc Chem Res (2012) 1.25
Application of microwave irradiation to the synthesis of 14-helical beta-peptides. Org Lett (2005) 1.24
Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenols. Science (2011) 1.24
Enantioselective Pd(II)-catalyzed aerobic oxidative amidation of alkenes and insights into the role of electronic asymmetry in pyridine-oxazoline ligands. Org Lett (2011) 1.23
Role of membrane lipids in the mechanism of bacterial species selective toxicity by two alpha/beta-antimicrobial peptides. Biochim Biophys Acta (2006) 1.23
Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones. Org Lett (2005) 1.22
Aerobic oxidative amination of unactivated alkenes catalyzed by palladium. J Am Chem Soc (2005) 1.22
Antifungal activity from 14-helical beta-peptides. J Am Chem Soc (2006) 1.21
Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. J Am Chem Soc (2002) 1.20
Ligand-modulated palladium oxidation catalysis: mechanistic insights into aerobic alcohol oxidation with the Pd(OAc)(2)/pyridine catalyst system. Org Lett (2002) 1.20
Mechanistic characterization of aerobic alcohol oxidation catalyzed by Pd(OAc)(2)/pyridine including identification of the catalyst resting state and the origin of nonlinear [catalyst] dependence. J Am Chem Soc (2004) 1.19
Chemoselective metal-free aerobic alcohol oxidation in lignin. J Am Chem Soc (2013) 1.18
Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides. Angew Chem Int Ed Engl (2004) 1.17
Access to poly-beta-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of beta-lactams. J Am Chem Soc (2009) 1.17
Residue requirements for helical folding in short alpha/beta-peptides: crystallographic characterization of the 11-helix in an optimized sequence. J Am Chem Soc (2005) 1.17
Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL. Chembiochem (2007) 1.16
Regioselective copper-catalyzed chlorination and bromination of arenes with O(2) as the oxidant. Chem Commun (Camb) (2009) 1.14
Analysis of the factors that stabilize a designed two-stranded antiparallel beta-sheet. Protein Sci (2002) 1.14
Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. J Am Chem Soc (2005) 1.13
Mechanistic study of alcohol oxidation by the Pd(OAc)(2)/O(2)/DMSO catalyst system and implications for the development of improved aerobic oxidation catalysts. J Am Chem Soc (2002) 1.11
Biocidal activity of polystyrenes that are cationic by virtue of protonation. Org Lett (2004) 1.10
Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry (2002) 1.10
Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization. Adv Synth Catal (2010) 1.10
Environment-independent 14-helix formation in short beta-peptides: striking a balance between shape control and functional diversity. J Am Chem Soc (2003) 1.09
Enantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands. J Am Chem Soc (2010) 1.09
Practical aerobic oxidations of alcohols and amines with homogeneous copper/TEMPO and related catalyst systems. Angew Chem Int Ed Engl (2014) 1.09
A rationally designed aldolase foldamer. Angew Chem Int Ed Engl (2009) 1.08
Reaction of molecular oxygen with a Pd(II)-hydride to produce a Pd(II)-hydroperoxide: experimental evidence for an HX-reductive-elimination pathway. J Am Chem Soc (2008) 1.08
Unexpected roles of molecular sieves in palladium-catalyzed aerobic alcohol oxidation. J Org Chem (2006) 1.08
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci (2008) 1.08
α-Helix mimicry with α/β-peptides. Methods Enzymol (2013) 1.07
Stabilizing and destabilizing effects of phenylalanine --> F5-phenylalanine mutations on the folding of a small protein. J Am Chem Soc (2006) 1.06
Efficient synthesis of enantiomerically pure beta2-amino acids via chiral isoxazolidinones. J Org Chem (2003) 1.06
Catalytic transamidation reactions compatible with tertiary amide metathesis under ambient conditions. J Am Chem Soc (2009) 1.06
Molecular architecture with functionalized beta-peptide helices. Angew Chem Int Ed Engl (2003) 1.06
Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
"Inverse-electron-demand" ligand substitution: experimental and computational insights into olefin exchange at palladium(0). J Am Chem Soc (2004) 1.04
Reversible alkene insertion into the Pd-N bond of Pd(II)-sulfonamidates and implications for catalytic amidation reactions. J Am Chem Soc (2011) 1.03
Mechanistic study of asymmetric oxidative biaryl coupling: evidence for self-processing of the copper catalyst to achieve control of oxidase vs oxygenase activity. J Am Chem Soc (2008) 1.03
Unexpected relationships between structure and function in alpha,beta-peptides: antimicrobial foldamers with heterogeneous backbones. J Am Chem Soc (2004) 1.03
Reconciling the stereochemical course of nucleopalladation with the development of enantioselective wacker-type cyclizations. Angew Chem Int Ed Engl (2012) 1.03
Enantioselective organocatalytic Michael additions of aldehydes to enones with imidazolidinones: cocatalyst effects and evidence for an enamine intermediate. J Am Chem Soc (2005) 1.02
Mechanism of Pd(OAc)2/pyridine catalyst reoxidation by O2: influence of labile monodentate ligands and identification of a biomimetic mechanism for O2 activation. Chemistry (2009) 1.02
Catalytic transamidation under moderate conditions. J Am Chem Soc (2003) 1.01
Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: importance of branching in the hydrophilic portion. Chembiochem (2008) 1.01
Highly stable redox-active molecular layers by covalent grafting to conductive diamond. J Am Chem Soc (2011) 1.01
Modular synthesis of 1,2-diamine derivatives by palladium-catalyzed aerobic oxidative cyclization of allylic sulfamides. Angew Chem Int Ed Engl (2010) 1.00
Discrete heterogeneous quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides. J Am Chem Soc (2007) 1.00
Copper(I)/ABNO-catalyzed aerobic alcohol oxidation: alleviating steric and electronic constraints of Cu/TEMPO catalyst systems. J Am Chem Soc (2013) 1.00
Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides. Org Lett (2007) 1.00
Antimicrobial 14-helical beta-peptides: potent bilayer disrupting agents. Biochemistry (2004) 1.00
Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra. J Am Chem Soc (2012) 0.99
Direct Aerobic α, β-Dehydrogenation of Aldehydes and Ketones with a Pd(TFA)(2)/4,5-Diazafluorenone Catalyst(). Chem Sci (2011) 0.98