Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 1112043)

Published in J Bacteriol on June 01, 2005

Authors

Florian D Ernst1, Georg Homuth, Jeroen Stoof, Ulrike Mäder, Barbara Waidner, Ernst J Kuipers, Manfred Kist, Johannes G Kusters, Stefan Bereswill, Arnoud H M van Vliet

Author Affiliations

1: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Dijkzigt L-4, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Articles citing this

Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev (2006) 7.72

Iron and fur regulation in Vibrio cholerae and the role of fur in virulence. Infect Immun (2005) 1.73

This is not your mother's repressor: the complex role of fur in pathogenesis. Infect Immun (2009) 1.71

Iron and pH homeostasis intersect at the level of Fur regulation in the gastric pathogen Helicobacter pylori. Infect Immun (2006) 1.48

The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pylori. Infect Immun (2005) 1.35

Analysis of a ferric uptake regulator (Fur) mutant of Desulfovibrio vulgaris Hildenborough. Appl Environ Microbiol (2007) 1.31

NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512). Infect Immun (2006) 1.22

Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr (2011) 1.20

Metalloregulatory proteins: metal selectivity and allosteric switching. Biophys Chem (2011) 1.19

Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol Rev (2014) 1.14

Regulation of oxidative stress response by CosR, an essential response regulator in Campylobacter jejuni. PLoS One (2011) 1.09

Methionine sulfoxide reductase in Helicobacter pylori: interaction with methionine-rich proteins and stress-induced expression. J Bacteriol (2006) 1.07

Characterization of the Fur regulon in Pseudomonas syringae pv. tomato DC3000. J Bacteriol (2011) 1.04

A single nucleotide change affects fur-dependent regulation of sodB in H. pylori. PLoS One (2009) 1.04

Change is good: variations in common biological mechanisms in the epsilonproteobacterial genera Campylobacter and Helicobacter. Microbiol Mol Biol Rev (2011) 1.01

Snapshot of iron response in Shewanella oneidensis by gene network reconstruction. BMC Genomics (2009) 1.01

Growth phase and metal-dependent transcriptional regulation of the fecA genes in Helicobacter pylori. J Bacteriol (2009) 0.99

Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol (2012) 0.98

Helicobacter pylori requires TlpD-driven chemotaxis to proliferate in the antrum. Infect Immun (2012) 0.98

Fur activates expression of the 2-oxoglutarate oxidoreductase genes (oorDABC) in Helicobacter pylori. J Bacteriol (2012) 0.97

Agrobacterium tumefaciens fur has important physiological roles in iron and manganese homeostasis, the oxidative stress response, and full virulence. Appl Environ Microbiol (2007) 0.97

The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins. J Bacteriol (2008) 0.96

Helicobacter pylori apo-Fur regulation appears unconserved across species. J Microbiol (2010) 0.94

Built shallow to maintain homeostasis and persistent infection: insight into the transcriptional regulatory network of the gastric human pathogen Helicobacter pylori. PLoS Pathog (2010) 0.94

Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae. J Bacteriol (2012) 0.93

Regulation of the Helicobacter pylori Fe-S cluster synthesis protein NifS by iron, oxidative stress conditions, and fur. J Bacteriol (2006) 0.93

Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole. PLoS One (2014) 0.92

Iron-responsive bacterial small RNAs: variations on a theme. Metallomics (2013) 0.92

Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease. Infect Immun (2010) 0.91

Mutagenesis of conserved amino acids of Helicobacter pylori fur reveals residues important for function. J Bacteriol (2010) 0.89

The Helicobacter pylori Ferric Uptake Regulator (Fur) is essential for growth under sodium chloride stress. J Microbiol (2011) 0.88

Identification and characterization of novel Helicobacter pylori apo-fur-regulated target genes. J Bacteriol (2013) 0.86

Metal-responsive gene regulation and metal transport in Helicobacter species. Biometals (2007) 0.84

Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur. Infect Immun (2006) 0.84

FeON-FeOFF: the Helicobacter pylori Fur regulator commutates iron-responsive transcription by discriminative readout of opposed DNA grooves. Nucleic Acids Res (2013) 0.83

The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach. Future Microbiol (2013) 0.81

Non-selective regulation of peroxide and superoxide resistance genes by PerR in Campylobacter jejuni. Front Microbiol (2015) 0.81

PerR controls peroxide- and iron-responsive expression of oxidative stress defense genes in Helicobacter hepaticus. Eur J Microbiol Immunol (Bp) (2011) 0.79

Metalloregulation of Helicobacter pylori physiology and pathogenesis. Front Microbiol (2015) 0.79

Random and site-specific mutagenesis of the Helicobacter pylori ferric uptake regulator provides insight into Fur structure-function relationships. Mol Microbiol (2013) 0.79

Identification of Differentially Abundant Proteins of Edwardsiella ictaluri during Iron Restriction. PLoS One (2015) 0.78

Integrative computational protocol for the discovery of inhibitors of the Helicobacter pylori nickel response regulator (NikR). J Mol Model (2011) 0.77

Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity. FEMS Microbiol Rev (2016) 0.76

Helicobacter pylori Adaptation In Vivo in Response to a High-Salt Diet. Infect Immun (2015) 0.76

The Role of the Regulator Fur in Gene Regulation and Virulence of Riemerella anatipestifer Assessed Using an Unmarked Gene Deletion System. Front Cell Infect Microbiol (2017) 0.75

Articles cited by this

The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 34.00

Helicobacter pylori infection. N Engl J Med (2002) 14.81

Bacterial iron homeostasis. FEMS Microbiol Rev (2003) 9.19

A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli. Proc Natl Acad Sci U S A (2002) 7.99

Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. Genes Dev (2003) 7.33

Oxidative stress. Curr Opin Microbiol (1999) 6.34

Opening the iron box: transcriptional metalloregulation by the Fur protein. J Bacteriol (1999) 5.83

Helicobacter pylori persistence: biology and disease. J Clin Invest (2004) 4.75

Role of oxidants in microbial pathophysiology. Clin Microbiol Rev (1997) 3.78

Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus. J Bacteriol (1990) 2.56

Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori. Mol Microbiol (2004) 2.26

Molecular hydrogen as an energy source for Helicobacter pylori. Science (2002) 2.12

The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori. Mol Microbiol (2001) 1.96

Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization. Infect Immun (2001) 1.94

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression. Microbiology (2005) 1.85

A comprehensive two-dimensional map of cytosolic proteins of Bacillus subtilis. Electrophoresis (2001) 1.79

Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. Infect Immun (1993) 1.78

Comparative proteome analysis of Helicobacter pylori. Mol Microbiol (2000) 1.73

Regulation of ferritin-mediated cytoplasmic iron storage by the ferric uptake regulator homolog (Fur) of Helicobacter pylori. J Bacteriol (2000) 1.66

The Helicobacter pylori homologue of the ferric uptake regulator is involved in acid resistance. Infect Immun (2002) 1.65

Dual channel imaging of two-dimensional electropherograms in Bacillus subtilis. Electrophoresis (1999) 1.65

Nickel-responsive induction of urease expression in Helicobacter pylori is mediated at the transcriptional level. Infect Immun (2001) 1.59

Oxidative-stress resistance mutants of Helicobacter pylori. J Bacteriol (2002) 1.45

Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori. Mol Microbiol (2004) 1.45

NapA protects Helicobacter pylori from oxidative stress damage, and its production is influenced by the ferric uptake regulator. J Med Microbiol (2003) 1.45

An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization. Infect Immun (2004) 1.45

Essential role of ferritin Pfr in Helicobacter pylori iron metabolism and gastric colonization. Infect Immun (2002) 1.43

Iron-dependent transcription of the frpB gene of Helicobacter pylori is controlled by the Fur repressor protein. J Bacteriol (2001) 1.34

Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressor. J Biol Chem (2002) 1.33

Catalase (KatA) and KatA-associated protein (KapA) are essential to persistent colonization in the Helicobacter pylori SS1 mouse model. Microbiology (2003) 1.30

The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptake. Helicobacter (2002) 1.29

Methionine sulphoxide reductase is an important antioxidant enzyme in the gastric pathogen Helicobacter pylori. Mol Microbiol (2004) 1.23

Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade. Infect Immun (2004) 1.22

Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated 'KatA-associated protein', KapA (HP0874). Microbiology (2002) 1.22

Contribution of the Helicobacter pylori thiol peroxidase bacterioferritin comigratory protein to oxidative stress resistance and host colonization. Infect Immun (2005) 1.20

Genes of Helicobacter pylori regulated by attachment to AGS cells. Infect Immun (2004) 1.17

Association of Helicobacter pylori antioxidant activities with host colonization proficiency. Infect Immun (2003) 1.17

Review article: Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther (1998) 1.12

Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori. Gene (1994) 1.03

pH-dependent protein profiles of Helicobacter pylori analyzed by two-dimensional gels. Helicobacter (2000) 0.93

Direct activity of recombinant human lactoferrin against Helicobacter pylori. J Clin Microbiol (1996) 0.83

The stress-induced hsp12 gene shows genetic variation among Helicobacter pylori strains. FEMS Immunol Med Microbiol (2003) 0.80

Articles by these authors

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut (2012) 12.62

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2015) 7.99

Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev (2006) 7.72

International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med (2010) 6.36

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet (2015) 6.13

Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet Oncol (2011) 5.72

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97

New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis. Gastroenterology (2013) 4.58

Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science (2012) 4.41

Cohort profile: the study of health in Pomerania. Int J Epidemiol (2010) 4.38

Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial. Ann Intern Med (2009) 4.11

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Risk of esophageal adenocarcinoma and mortality in patients with Barrett's esophagus: a systematic review and meta-analysis. Clin Gastroenterol Hepatol (2009) 3.66

The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44

The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24

Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology (2008) 3.18

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18

Helicobacter pylori as a prognostic indicator after curative resection of gastric carcinoma: a prospective study. Lancet Oncol (2006) 3.18

Competence measurement during colonoscopy training: the use of self-assessment of performance measures. Am J Gastroenterol (2012) 3.17

Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA (2013) 3.15

Canadian Association of Gastroenterology consensus guidelines on safety and quality indicators in endoscopy. Can J Gastroenterol (2012) 3.15

Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology (2005) 3.10

Cost-effectiveness analysis of a quantitative immunochemical test for colorectal cancer screening. Gastroenterology (2011) 3.08

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59

Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut (2012) 2.49

Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis. J Bacteriol (2002) 2.47

Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One (2008) 2.39

Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science (2012) 2.38

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med (2009) 2.28

Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review. BMC Gastroenterol (2007) 2.26

Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: an updated meta-analysis. J Gastroenterol Hepatol (2011) 2.24

Chronic gastrointestinal ischaemia: shifting paradigms. Gut (2010) 2.23

Colorectal neoplasia in veterans is associated with Barrett's esophagus but not with proton-pump inhibitor or aspirin/NSAID use. Gastrointest Endosc (2006) 2.10

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10

Quality evaluation of colonoscopy reporting and colonoscopy performance in daily clinical practice. Gastrointest Endosc (2011) 2.09

Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial. Lancet (2004) 2.06

High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome. Gut (2011) 2.06

Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05

Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis (2006) 2.02

A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis (2010) 1.99

Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation. Inflamm Bowel Dis (2011) 1.97

Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastrointest Endosc (2009) 1.97

Transcriptome and proteome analysis of Bacillus subtilis gene expression in response to superoxide and peroxide stress. Microbiology (2004) 1.96

Proton pump inhibitors reduce the risk of neoplastic progression in patients with Barrett's esophagus. Clin Gastroenterol Hepatol (2012) 1.96

The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828). J Bacteriol (2007) 1.94

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut (2010) 1.93

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92

Cure of Barrett's carcinoma by ifosfamide chemotherapy. Eur J Gastroenterol Hepatol (2002) 1.92

A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet (2012) 1.91

Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet (2010) 1.91

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90

Effect of rising chemotherapy costs on the cost savings of colorectal cancer screening. J Natl Cancer Inst (2009) 1.89

Differences in proximal serrated polyp detection among endoscopists are associated with variability in withdrawal time. Gastrointest Endosc (2013) 1.87

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression. Microbiology (2005) 1.85

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation (2013) 1.77

Electrocautery therapy for refractory anastomotic strictures of the esophagus. Gastrointest Endosc (2006) 1.76

Single-balloon-assisted colonoscopy in patients with previously failed colonoscopy. Gastrointest Endosc (2010) 1.74

The risk of inflammatory bowel disease-related colorectal carcinoma is limited: results from a nationwide nested case-control study. Am J Gastroenterol (2010) 1.73

Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage. Ann Surg (2010) 1.70

ERCP as an outpatient treatment: a review. Gastrointest Endosc (2008) 1.68

Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68

Risk of malignant progression in patients with Barrett's oesophagus: a Dutch nationwide cohort study. Gut (2010) 1.68

Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67

Pathogenesis and treatment of Budd-Chiari syndrome combined with portal vein thrombosis. Am J Gastroenterol (2006) 1.66

Are fecal immunochemical test characteristics influenced by sample return time? A population-based colorectal cancer screening trial. Am J Gastroenterol (2011) 1.66

A randomized comparison of electrocautery incision with Savary bougienage for relief of anastomotic gastroesophageal strictures. Gastrointest Endosc (2009) 1.66

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut (2009) 1.65

The Helicobacter pylori homologue of the ferric uptake regulator is involved in acid resistance. Infect Immun (2002) 1.65

Challenges in the management of acute peptic ulcer bleeding. Lancet (2013) 1.65

Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng (2003) 1.64

Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease. Sci Transl Med (2014) 1.64

Esophageal stents with antireflux valve for tumors of the distal esophagus and gastric cardia: a randomized trial. Gastrointest Endosc (2004) 1.64

Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice. PLoS One (2012) 1.63

Labeled versus unlabeled discrete choice experiments in health economics: an application to colorectal cancer screening. Value Health (2009) 1.61

mRNA processing by RNases J1 and J2 affects Bacillus subtilis gene expression on a global scale. Mol Microbiol (2008) 1.61