Published in Sci Signal on November 17, 2009
Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol (2010) 2.87
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7. Proc Natl Acad Sci U S A (2012) 1.30
Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol (2011) 1.19
The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching. J Proteome Res (2011) 1.17
Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii. Eukaryot Cell (2012) 1.13
A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell (2011) 1.09
Cell signaling, post-translational protein modifications and NMR spectroscopy. J Biomol NMR (2012) 1.06
Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation. PLoS One (2011) 1.04
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Protein lysine acetylation by p300/CBP. Chem Rev (2015) 1.02
Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA. PLoS Pathog (2013) 1.00
HDAC inhibitors in experimental liver and kidney fibrosis. Fibrogenesis Tissue Repair (2013) 0.96
Acetylation of αA-crystallin in the human lens: effects on structure and chaperone function. Biochim Biophys Acta (2011) 0.94
2-cys peroxiredoxins: emerging hubs determining redox dependency of Mammalian signaling networks. Int J Cell Biol (2014) 0.93
Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation. Neurobiol Learn Mem (2011) 0.93
Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery. Int J Cell Biol (2010) 0.90
Deacetylase inhibitors - focus on non-histone targets and effects. World J Biol Chem (2010) 0.90
Inhibition of histone deacetylases in inflammatory bowel diseases. Mol Med (2011) 0.89
Human 14-3-3 paralogs differences uncovered by cross-talk of phosphorylation and lysine acetylation. PLoS One (2013) 0.88
Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Mol Biosyst (2013) 0.88
Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics. Genome Med (2013) 0.87
Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin. Biochem Biophys Res Commun (2011) 0.84
Myelodysplastic syndrome and histone deacetylase inhibitors: "to be or not to be acetylated"? J Biomed Biotechnol (2011) 0.83
Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide. J Biol Chem (2010) 0.83
Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii. PLoS One (2015) 0.81
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. Antimicrob Agents Chemother (2015) 0.81
Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. Mol Biol Cell (2014) 0.81
An intelligent system for identifying acetylated lysine on histones and nonhistone proteins. Biomed Res Int (2014) 0.80
Proteome-wide analysis of lysine acetylation in the plant pathogen Botrytis cinerea. Sci Rep (2016) 0.78
Post-translational modification of proteins in toxicological research: focus on lysine acylation. Toxicol Res (2013) 0.78
Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. Sci Rep (2017) 0.78
Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial Phosphatase. J Biol Chem (2015) 0.77
Validation of protein acetylation by mass spectrometry. Methods Mol Biol (2013) 0.77
Mechanical and IL-1β Responsive miR-365 Contributes to Osteoarthritis Development by Targeting Histone Deacetylase 4. Int J Mol Sci (2016) 0.77
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. ACS Chem Biol (2015) 0.77
PPARα activation induces N(ε)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1. Lipids (2013) 0.75
Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats. Korean J Physiol Pharmacol (2016) 0.75
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis. J Clin Invest (2017) 0.75
Translating the histone code. Science (2001) 56.77
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
Acetylation: a regulatory modification to rival phosphorylation? EMBO J (2000) 7.35
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol (2006) 6.25
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms. J Cell Biol (1985) 5.47
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev (1999) 4.92
PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites. Genome Biol (2007) 4.66
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem (2005) 4.62
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science (2002) 4.61
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov (2008) 4.43
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem (2009) 3.88
Chlamydomonas alpha-tubulin is posttranslationally modified by acetylation on the epsilon-amino group of a lysine. Biochemistry (1985) 3.75
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A (1999) 3.26
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell (2004) 2.43
Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther (2003) 2.15
Intrinsic protein disorder, amino acid composition, and histone terminal domains. J Biol Chem (2005) 1.98
Histone H2A.Z acetylation modulates an essential charge patch. Mol Cell (2001) 1.81
Chemical studies of histone acetylation. The occurrence of epsilon-N-acetyllysine in the f2a1 histone. J Biol Chem (1968) 1.53
Histone deacetylase inhibitors in inflammatory disease. Curr Top Med Chem (2009) 1.46
VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. J Biol Chem (2007) 1.40
AcK-knowledge reversible acetylation. Sci STKE (2004) 1.39
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem (2001) 2.18
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem (2005) 2.01
Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J Neurosci (2005) 2.00
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem (2005) 1.81
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70
Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem (2003) 1.50
AcK-knowledge reversible acetylation. Sci STKE (2004) 1.39
The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol (2009) 1.31
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res (2005) 1.28
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol Cell (2003) 1.26
Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. Mol Cell Biol (2005) 1.18
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci (2004) 1.15
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12
Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell (2013) 1.10
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. FASEB J (2008) 1.09
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. PLoS One (2012) 1.08
FBW2 targets GCMa to the ubiquitin-proteasome degradation system. J Biol Chem (2005) 1.07
The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. J Biol Chem (2007) 1.07
A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. Mol Cell (2012) 1.05
Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. J Mol Biol (2007) 1.02
Retracted Contribution of the PI3K/Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells. FEBS Lett (2005) 1.01
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem (2002) 1.00
Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. J Biol Chem (2005) 1.00
Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton. Autophagy (2010) 1.00
Histone deacetylase 3 binds to and regulates the GCMa transcription factor. Nucleic Acids Res (2006) 1.00
Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res (2010) 0.99
Mitochondrial dynamics and Parkinson's disease: focus on parkin. Antioxid Redox Signal (2011) 0.99
Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. J Gynecol Oncol (2008) 0.99
E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. J Cell Biol (2008) 0.97
Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. J Neurochem (2004) 0.95
Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo. Invest Ophthalmol Vis Sci (2004) 0.93
Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. FEBS Lett (2003) 0.93
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. Biochem Biophys Res Commun (2008) 0.93
Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr (2010) 0.92
Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Mol Cells (2013) 0.91
Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nat Commun (2013) 0.89
Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease. J Neurosci Res (2008) 0.88
The HDAC complex and cytoskeleton. Novartis Found Symp (2004) 0.85
Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Protein Cell (2014) 0.85
Inhibitory effects of berberine on lipopolysaccharide-induced inducible nitric oxide synthase and the high-mobility group box 1 release in macrophages. Biochem Biophys Res Commun (2013) 0.84
Pyruvate protects against kainate-induced epileptic brain damage in rats. Exp Neurol (2007) 0.83
Neuroprotection by urokinase plasminogen activator in the hippocampus. Neurobiol Dis (2012) 0.83
Analysis of differential plaque depositions in the brains of Tg2576 and Tg-APPswe/PS1dE9 transgenic mouse models of Alzheimer disease. Exp Mol Med (2012) 0.83
A mechanism of COOH-terminal binding protein-mediated repression. Mol Cancer Res (2005) 0.83
Association of GWAS top hits with late-onset Alzheimer disease in Korean population. Alzheimer Dis Assoc Disord (2013) 0.83
Endogenous zinc mediates apoptotic programmed cell death in the developing brain. Neurotox Res (2009) 0.82
Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice. Neurobiol Dis (2009) 0.81
Tissue plasminogen activator arrests Alzheimer's disease pathogenesis. Neurobiol Aging (2013) 0.81
Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain. Ann Neurol (2015) 0.80
HDACs in skeletal muscle remodeling and neuromuscular disease. Handb Exp Pharmacol (2011) 0.80
Zinc-triggered induction of tissue plasminogen activator by brain-derived neurotrophic factor and metalloproteinases. J Neurochem (2011) 0.79
Induction of nuclear factor-kappaB activation through TAK1 and NIK by diesel exhaust particles in L2 cell lines. Toxicol Lett (2005) 0.78
Chaperoning steroid hormone signaling via reversible acetylation. Nucl Recept Signal (2005) 0.78
Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model. Yonsei Med J (2005) 0.78
Retraction notice to "Contribution of the PI3K/Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells" [FEBS Lett. 579 (2005) 534-540]. FEBS Lett (2006) 0.77
Calsenilin contributes to neuronal cell death in ischemic stroke. Brain Pathol (2012) 0.77
Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment. Anal Bioanal Chem (2014) 0.76
Lysine modifications and autophagy. Essays Biochem (2012) 0.76
Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model. Neurodegener Dis (2015) 0.76
The discovery of histone deacetylase. Handb Exp Pharmacol (2011) 0.75