Published in J Physiol on June 16, 2005
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
The cellular code for mammalian thermosensation. J Neurosci (2013) 1.24
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol (2007) 1.16
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Converting cold into pain. Exp Brain Res (2009) 1.06
Thermal and nociceptive sensations from menthol and their suppression by dynamic contact. Behav Brain Res (2006) 1.00
Pirt functions as an endogenous regulator of TRPM8. Nat Commun (2013) 0.97
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem (2012) 0.97
What Causes Eye Pain? Curr Ophthalmol Rep (2015) 0.97
Mechano- and thermosensitivity of regenerating cutaneous afferent nerve fibers. Exp Brain Res (2009) 0.93
TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. J Endod (2007) 0.89
Corneal dry-responsive neurons in the spinal trigeminal nucleus respond to innocuous cooling in the rat. J Neurophysiol (2013) 0.84
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res (2013) 0.81
Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease. Pain (2016) 0.79
Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain. J Biol Chem (2014) 0.78
The influence of cold temperature on cellular excitability of hippocampal networks. PLoS One (2012) 0.77
TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Pflugers Arch (2015) 0.77
Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution. PeerJ (2015) 0.77
Barium ions inhibit the dynamic response of guinea-pig corneal cold receptors to heating but not to cooling. J Physiol (2006) 0.76
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature (1999) 10.05
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (2002) 8.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
painless, a Drosophila gene essential for nociception. Cell (2003) 4.93
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
Induction of vanilloid receptor channel activity by protein kinase C. Nature (2001) 3.95
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 3.51
ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat Rev Neurosci (2003) 3.42
TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (2002) 3.23
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron (2002) 3.17
Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol (2003) 3.14
Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc Natl Acad Sci U S A (2004) 3.11
Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci (2002) 3.01
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol (2001) 2.94
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol (2001) 2.88
TREK-1 is a heat-activated background K(+) channel. EMBO J (2000) 2.82
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem (2002) 2.79
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.59
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest (2003) 2.09
A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction. J Physiol (2002) 1.97
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc Natl Acad Sci U S A (2001) 1.75
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol (2005) 1.75
TRPV channels as temperature sensors. Cell Calcium (2003) 1.63
Menthol-induced Ca2+ release from presynaptic Ca2+ stores potentiates sensory synaptic transmission. J Neurosci (2004) 1.44
Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones. Neurosci Lett (2001) 1.44
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci (2004) 1.39
Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. Eur J Neurosci (2004) 1.38
ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch (2005) 1.30
TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat. J Neurophysiol (2003) 1.30
TRP trapped in fly signaling web. Curr Opin Neurobiol (1998) 1.28
Swelling-activated calcium signalling in cultured mouse primary sensory neurons. Eur J Neurosci (2001) 1.23
Cold transduction in rat trigeminal ganglia neurons in vitro. Neuroscience (2003) 1.14
Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the guinea-pig cornea. J Physiol (2001) 1.10
Cutaneous temperature receptors. Annu Rev Physiol (1986) 1.06
Effects of heating and cooling on nerve terminal impulses recorded from cold-sensitive receptors in the guinea-pig cornea. J Gen Physiol (2003) 1.06
Ionic basis of cold receptors acting as thermostats. J Neurosci (2002) 0.96
Differential thermosensitivity of sensory neurons in the guinea pig trigeminal ganglion. J Neurophysiol (2003) 0.89
Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci (2002) 3.01
Inhibition of a background potassium channel by Gq protein alpha-subunits. Proc Natl Acad Sci U S A (2006) 1.63
Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci (2009) 1.61
TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci (2008) 1.53
Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ keratomileusis. J Refract Surg (2004) 1.52
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med (2010) 1.50
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. J Neurosci (2006) 1.46
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Cell Mol Life Sci (2011) 1.42
Decreased corneal sensitivity in patients with dry eye. Invest Ophthalmol Vis Sci (2005) 1.23
Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci U S A (2002) 1.19
Effects of different molecular weight elastoviscous hyaluronan solutions on articular nociceptive afferents. Arthritis Rheum (2004) 1.18
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol (2007) 1.16
Direct inhibition of the cold-activated TRPM8 ion channel by Gαq. Nat Cell Biol (2012) 1.15
A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J Neurosci (2007) 1.13
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J (2008) 1.12
TRPA1 channels: novel targets of 1,4-dihydropyridines. Channels (Austin) (2008) 1.12
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Lipid raft segregation modulates TRPM8 channel activity. J Biol Chem (2009) 1.09
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Tear secretion induced by selective stimulation of corneal and conjunctival sensory nerve fibers. Invest Ophthalmol Vis Sci (2004) 1.06
Effects of heating and cooling on nerve terminal impulses recorded from cold-sensitive receptors in the guinea-pig cornea. J Gen Physiol (2003) 1.06
Radio-frequency energy delivery to the anal canal for the treatment of fecal incontinence. Dis Colon Rectum (2002) 1.04
Selective changes in human corneal sensation associated with herpes simplex virus keratitis. Invest Ophthalmol Vis Sci (2010) 1.04
Extended two-year results of radio-frequency energy delivery for the treatment of fecal incontinence (the Secca procedure). Dis Colon Rectum (2003) 0.98
Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. J Cell Sci (2006) 0.97
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem (2012) 0.97
The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci (2013) 0.97
Regeneration of functional nerves within full thickness collagen-phosphorylcholine corneal substitute implants in guinea pigs. Biomaterials (2009) 0.96
Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A (2009) 0.94
TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. PLoS One (2012) 0.93
SECCA procedure for the treatment of fecal incontinence: results of five-year follow-up. Dis Colon Rectum (2008) 0.92
Nociceptive nerve activity in an experimental model of knee joint osteoarthritis of the guinea pig: effect of intra-articular hyaluronan application. Pain (2007) 0.92
Postnatal changes in membrane properties of mice trigeminal ganglion neurons. J Neurophysiol (2002) 0.91
Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge. Brain (2013) 0.89
The TFOS International Workshop on Contact Lens Discomfort: executive summary. Invest Ophthalmol Vis Sci (2013) 0.89
Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity. FASEB J (2011) 0.89
TRPM8. Handb Exp Pharmacol (2014) 0.88
Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. J Biol Chem (2007) 0.88
Pharmacological and functional properties of TRPM8 channels in prostate tumor cells. Pflugers Arch (2010) 0.88
Sustained axon-glial signaling induces Schwann cell hyperproliferation, Remak bundle myelination, and tumorigenesis. J Neurosci (2009) 0.86
Cold sensitivity in axotomized fibers of experimental neuromas in mice. Pain (2005) 0.86
Amplified cold transduction in native nociceptors by M-channel inhibition. J Neurosci (2013) 0.86
Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors. J Physiol (2009) 0.85
Impulse activity in corneal sensory nerve fibers after photorefractive keratectomy. Invest Ophthalmol Vis Sci (2007) 0.85
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. Mol Pain (2009) 0.84
Influence of age, gender and iris color on mechanical and chemical sensitivity of the cornea and conjunctiva. Exp Eye Res (2006) 0.83
Altered thermal sensitivity in neurons injured by infraorbital nerve lesion. Neurosci Lett (2010) 0.83
Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology (2011) 0.83
Role of Ih in the firing pattern of mammalian cold thermoreceptor endings. J Neurophysiol (2012) 0.83
Decreased corneal sensitivity and tear production in fibromyalgia. Invest Ophthalmol Vis Sci (2009) 0.82
Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis. Pain (2013) 0.82
Comparative effects of the nonsteroidal anti-inflammatory drug nepafenac on corneal sensory nerve fibers responding to chemical irritation. Invest Ophthalmol Vis Sci (2007) 0.82
Tau function and dysfunction in neurons: its role in neurodegenerative disorders. Mol Neurobiol (2002) 0.81
Corneal sensitivity in diabetic patients subjected to retinal laser photocoagulation. Invest Ophthalmol Vis Sci (2011) 0.81
Activation of scleral cold thermoreceptors by temperature and blood flow changes. Invest Ophthalmol Vis Sci (2003) 0.81
L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. PLoS One (2012) 0.80
GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity. EMBO J (2003) 0.79
Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease. Pain (2016) 0.79
Changes in mechanical, chemical, and thermal sensitivity of the cornea after topical application of nonsteroidal anti-inflammatory drugs. Invest Ophthalmol Vis Sci (2005) 0.77
The influence of cold temperature on cellular excitability of hippocampal networks. PLoS One (2012) 0.77
Potassium channels shape and brake primary sensory neurone excitability. J Physiol (2008) 0.76
Barium ions inhibit the dynamic response of guinea-pig corneal cold receptors to heating but not to cooling. J Physiol (2006) 0.76
Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea. Invest Ophthalmol Vis Sci (2014) 0.75
Funny currents are becoming serious players in nociceptor's sensitization. J Physiol (2008) 0.75
Personal profile. Carlos Belmonte, MD, PhD. Ocul Surf (2011) 0.75
Optimization of electrically tunable VCSEL with intracavity nematic liquid crystal. Opt Express (2015) 0.75