Published in Nature on February 10, 2002
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A neural circuit mechanism integrating motivational state with memory expression in Drosophila. Cell (2009) 3.51
Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc Natl Acad Sci U S A (2004) 3.11
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
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Recommendations for the management of cough in adults. Thorax (2006) 2.41
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell (2013) 2.25
Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci U S A (2003) 2.22
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20
Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
Nociceptor sensitization in pain pathogenesis. Nat Med (2010) 2.13
Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons. Proc Natl Acad Sci U S A (2003) 2.09
Vapor rub, petrolatum, and no treatment for children with nocturnal cough and cold symptoms. Pediatrics (2010) 2.09
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
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TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain (2010) 2.06
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci (2007) 2.00
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction. J Physiol (2002) 1.97
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol (2004) 1.97
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci (2010) 1.92
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol (2008) 1.85
Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am J Physiol Heart Circ Physiol (2009) 1.85
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain (2005) 1.84
Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci (2007) 1.82
Thermodynamics of heat activation of single capsaicin ion channels VR1. Biophys J (2003) 1.78
TRPV1-lineage neurons are required for thermal sensation. EMBO J (2010) 1.77
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol (2005) 1.75
A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A (2011) 1.74
Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Proc Natl Acad Sci U S A (2008) 1.74
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66
Inorganic polyphosphate modulates TRPM8 channels. PLoS One (2009) 1.64
Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A (2013) 1.64
A molecular framework for temperature-dependent gating of ion channels. Cell (2014) 1.64
Warm-Sensitive Neurons that Control Body Temperature. Cell (2016) 1.61
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.57
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits. Curr Opin Neurobiol (2011) 1.55
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Monoterpenoid agonists of TRPV3. Br J Pharmacol (2007) 1.50
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50
Nociceptive sensations evoked from 'spots' in the skin by mild cooling and heating. Pain (2008) 1.50
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med (2010) 1.50
Calcium channels and pumps in cancer: changes and consequences. J Biol Chem (2012) 1.49
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. J Clin Invest (2007) 1.49
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Central control of brown adipose tissue thermogenesis. Front Endocrinol (Lausanne) (2012) 1.47
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
Nociceptors: a phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2009) 1.44
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
The CatSper channel: a polymodal chemosensor in human sperm. EMBO J (2012) 1.40
Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies. Biophys J (2009) 1.39
Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. J Neurosci (2009) 1.39
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J Neurosci (2013) 1.38
Regulation of TRP channels by PIP(2). Pflugers Arch (2006) 1.37
Labeled lines meet and talk: population coding of somatic sensations. J Clin Invest (2010) 1.36
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol (2010) 1.36
Regional peak mucosal cooling predicts the perception of nasal patency. Laryngoscope (2013) 1.35
Modulation of TRPs by PIPs. J Physiol (2007) 1.35
Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS One (2011) 1.34
Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One (2011) 1.34
Histamine-induced itch and its relationship with pain. Mol Pain (2008) 1.34
OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. Nature (2014) 1.34
Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci (2003) 1.34
Rapid optical control of nociception with an ion-channel photoswitch. Nat Methods (2012) 1.33
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J (2011) 1.33
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol (2004) 1.32
TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.31
ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch (2005) 1.30
Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol (2004) 1.30
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflugers Arch (2005) 1.28
A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet (2008) 1.28
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats. Mol Pain (2005) 1.26
Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: glutamate release by capsaicin and menthol. J Physiol (2003) 1.26
Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. BMC Urol (2006) 1.26
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain (2010) 1.25
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16
Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature (2013) 5.75
TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A (2006) 5.41
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93
Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell (2002) 4.57
Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A (2005) 4.20
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 3.51
Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol (2003) 3.14
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
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A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature (2011) 1.84
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci (2005) 1.83
The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci (2002) 1.82
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron (2008) 1.79
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci (2008) 1.66
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature (2011) 1.49
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci (2011) 1.40
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A (2008) 1.24
Evolution of thermal response properties in a cold-activated TRP channel. PLoS One (2009) 1.22
Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor. Physiol Behav (2004) 1.03
Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci (2004) 0.97
Receptor-targeting mechanisms of pain-causing toxins: How ow? Toxicon (2012) 0.95
Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol (2004) 0.92
Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol (2008) 0.92
Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci (2004) 0.90
Fire in the hole: pore dilation of the capsaicin receptor TRPV1. Nat Neurosci (2008) 0.90
Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 0.87
TRP channel structural biology: new roles for an old fold. Neuron (2007) 0.82
Toward better pain control. Sci Am (2006) 0.82
Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole. Proc Natl Acad Sci U S A (2006) 0.81
Ion pair reinforced semi-interpenetrating polymer network for direct methanol fuel cell applications. J Phys Chem B (2012) 0.75