Published in Development on June 29, 2005
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest (2006) 1.88
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol (2009) 1.70
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
Maternal hypoxia activates endovascular trophoblast cell invasion. Dev Biol (2007) 1.32
Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A (2006) 1.28
The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol (2010) 1.23
Hypoxia and fetal heart development. Curr Mol Med (2010) 1.16
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development (2011) 1.15
FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem (2009) 1.14
Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. J Biomed Biotechnol (2010) 1.02
Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells (2013) 1.01
PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS One (2009) 1.01
Importance of the matriline for genomic imprinting, brain development and behaviour. Philos Trans R Soc Lond B Biol Sci (2013) 0.98
Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia. J Reprod Immunol (2010) 0.91
Oxygen and Cell Fate Decisions. Gene Regul Syst Bio (2008) 0.91
Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod (2009) 0.91
Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia. J Biol Chem (2009) 0.90
RNA-seq analysis of the functional compartments within the rat placentation site. Endocrinology (2012) 0.89
Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. Int J Dev Biol (2014) 0.87
Inflammation, HIF-1, and the epigenetics that follows. Mediators Inflamm (2010) 0.87
Benzopyrene and experimental stressors cause compensatory differentiation in placental trophoblast stem cells. Syst Biol Reprod Med (2010) 0.87
Effects of hypoxia inducible factors-1α on autophagy and invasion of trophoblasts. Clin Exp Reprod Med (2012) 0.87
ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One (2013) 0.85
PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro. Exp Mol Med (2010) 0.83
Preeclampsia, of mice and women. Physiol Genomics (2016) 0.82
Regulatory pathways controlling the endovascular invasive trophoblast cell lineage. J Reprod Dev (2012) 0.81
NK cells, hypoxia and trophoblast cell differentiation. Cell Cycle (2012) 0.81
A molecular signature of an arrest of descent in human parturition. Am J Obstet Gynecol (2011) 0.81
Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor. J Perinat Med (2013) 0.81
Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation. J Biol Chem (2011) 0.80
Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci (2014) 0.80
Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway? Mediators Inflamm (2015) 0.79
Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A (2016) 0.78
Hypoxia and trophoblast differentiation: a key role for PPARγ. Stem Cells Dev (2013) 0.78
Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro. Biomol Ther (Seoul) (2012) 0.78
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol (2014) 0.77
Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation. Reproduction (2014) 0.77
Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. Sci Rep (2016) 0.77
HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proc Natl Acad Sci U S A (2016) 0.76
Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia. Stem Cells (2016) 0.76
Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol (2017) 0.75
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol (2017) 0.75
Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn (2016) 0.75
CITED2 modulation of trophoblast cell differentiation: insights from global transcriptome analysis. Reproduction (2016) 0.75
Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. PLoS Genet (2016) 0.75
Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta. Cell Adh Migr (2016) 0.75
Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells. Int J Cell Biol (2017) 0.75
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16
Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev (2006) 5.15
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell (2008) 4.84
Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem (2003) 3.88
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res (2010) 3.08
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol (2002) 2.99
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest (2004) 2.95
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev (2004) 2.77
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell (2007) 2.58
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol (2006) 2.56
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest (2009) 2.47
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science (2003) 2.40
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics (2009) 2.39
Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest (2003) 2.37
An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics (2009) 2.09
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Res (2005) 2.07
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest (2006) 1.88
Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol (2006) 1.87
HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A (2010) 1.86
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell (2003) 1.85
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
Sweetening the pot: adding glycosylation to the biomarker discovery equation. Clin Chem (2009) 1.81
Regulation of transcription and translation by hypoxia. Cancer Biol Ther (2004) 1.74
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell (2012) 1.71
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem (2002) 1.70
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol (2005) 1.67
Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol (2003) 1.67
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.63
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
HIFs, hypoxia, and vascular development. Curr Top Dev Biol (2004) 1.60
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59
Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology (2006) 1.58
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res (2010) 1.57
von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J Clin Invest (2007) 1.56
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51
Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol (2010) 1.51
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
Reactive oxygen species and cellular oxygen sensing. Free Radic Biol Med (2007) 1.49
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology (2008) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest (2010) 1.46
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov (2013) 1.44
Trophoblast stem cells. Biol Reprod (2010) 1.42
Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development (2004) 1.41
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40
Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun (2006) 1.40
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest (2009) 1.40
Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertil Steril (2005) 1.39
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther (2005) 1.38
Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun (2004) 1.35
The importance of PU.1 concentration in hematopoietic lineage commitment and maturation. Blood Cells Mol Dis (2003) 1.34
HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest (2013) 1.32
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med (2011) 1.31
Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res (2004) 1.30
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells (2007) 1.30
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem (2006) 1.29
Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27
Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell (2005) 1.26
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A (2002) 1.26
Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biol (2005) 1.25
Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C. Dev Biol (2003) 1.24
HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell (2006) 1.23
Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry (2005) 1.22
The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem (2006) 1.22
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res (2004) 1.20