The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.

PubWeight™: 2.77‹?› | Rank: Top 1%

🔗 View Article (PMC 517513)

Published in Genes Dev on September 15, 2004

Authors

Amato J Giaccia1, M Celeste Simon, Randall Johnson

Author Affiliations

1: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA. giaccia@stanford.edu

Articles citing this

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04

MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem (2008) 4.69

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell (2007) 4.46

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29

Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell (2007) 2.58

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol (2006) 2.56

Bacterial community morphogenesis is intimately linked to the intracellular redox state. J Bacteriol (2013) 2.00

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95

Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med (2008) 1.93

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics (2007) 1.71

Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res (2009) 1.68

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68

Sensing and signalling in response to oxygen deprivation in plants and other organisms. Ann Bot (2005) 1.48

Adaptive myogenesis under hypoxia. Mol Cell Biol (2005) 1.38

Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol (2012) 1.36

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet (2010) 1.34

Hypoxia, HIFs and bone development. Bone (2010) 1.29

Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol (2010) 1.28

Molecular analysis of tumor margins by MALDI mass spectrometry in renal carcinoma. J Proteome Res (2010) 1.27

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2011) 1.23

HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell (2006) 1.23

Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. J Biol Chem (2010) 1.20

Early fetal hypoxia leads to growth restriction and myocardial thinning. Am J Physiol Regul Integr Comp Physiol (2008) 1.19

Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med (2009) 1.19

Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16

CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res (2012) 1.16

Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO J (2007) 1.13

Direct tissue analysis by matrix-assisted laser desorption ionization mass spectrometry: application to kidney biology. Semin Nephrol (2007) 1.13

HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem (2008) 1.10

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells. Am J Physiol Cell Physiol (2010) 1.10

The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery. Front Physiol (2013) 1.07

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics. Cancer Biol Ther (2010) 1.06

Hypoxia-induced signaling in the cardiovascular system. Annu Rev Physiol (2008) 1.04

Epigenetic regulation of BMP7 in the regenerative response to ischemia. J Am Soc Nephrol (2008) 1.03

Hypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases. Curr Drug Targets (2013) 1.01

The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev (2012) 1.01

HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res (2014) 1.00

Cochlear pericyte responses to acoustic trauma and the involvement of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Am J Pathol (2009) 0.99

Side effects of radiographic contrast media: pathogenesis, risk factors, and prevention. Biomed Res Int (2014) 0.99

Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest (2005) 0.98

Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One (2010) 0.97

IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model. PLoS One (2013) 0.95

Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development (2006) 0.94

Acute kidney injury by radiographic contrast media: pathogenesis and prevention. Biomed Res Int (2014) 0.93

Gestation dependant changes in angiogenic factors and their associations with fetal growth measures in normotensive pregnancy. PLoS One (2013) 0.92

HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions. Int J Cancer (2012) 0.92

Redox-driven regulation of microbial community morphogenesis. Curr Opin Microbiol (2014) 0.91

Surviving hypoxia by modulation of mRNA translation rate. J Cell Mol Med (2009) 0.91

Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis. Sci Rep (2012) 0.90

Prevention of contrast-induced nephropathy through a knowledge of its pathogenesis and risk factors. ScientificWorldJournal (2014) 0.90

Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential. Stem Cells Int (2013) 0.88

Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. PLoS One (2011) 0.87

Hypoxia elicits broad and systematic changes in protein subcellular localization. Am J Physiol Cell Physiol (2011) 0.85

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med (2008) 0.85

Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors. Genes Cells (2012) 0.84

Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control. J Biol Chem (2009) 0.84

Transcription regulation of HYPK by Heat Shock Factor 1. PLoS One (2014) 0.83

Hypoxia enhances differentiation of mouse embryonic stem cells into definitive endoderm and distal lung cells. Stem Cells Dev (2014) 0.82

Chronic hypoxia impairs cytochrome oxidase activity via oxidative stress in selected fetal Guinea pig organs. Reprod Sci (2012) 0.81

High oxygen prevents fetal lethality due to lack of catecholamines. Am J Physiol Regul Integr Comp Physiol (2008) 0.81

Polyubiquitinated proteins, proteasome, and glycogen characterize the particle-rich cytoplasmic structure (PaCS) of neoplastic and fetal cells. Histochem Cell Biol (2014) 0.80

Molecular expression and functional activity of efflux and influx transporters in hypoxia induced retinal pigment epithelial cells. Int J Pharm (2013) 0.80

Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans. Sci Rep (2014) 0.79

Effect of creatine monohydrate supplementation on various hematological and serum biochemical parameters of male albino mice following neonatal hypoxia-ischemia encephalopathy. ScientificWorldJournal (2013) 0.78

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression. PLoS One (2015) 0.78

Posttranslational modifications of collagens as targets of hypoxia and Hif-1alpha in endochondral bone development. Ann N Y Acad Sci (2010) 0.78

Oxygen depletion speeds and simplifies diffusion in HeLa cells. Biophys J (2014) 0.78

Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance. Physiol Genomics (2011) 0.78

Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression. Cell Death Differ (2010) 0.78

Distribution of Gemcitabine Is Nearly Homogenous in Two Orthotopic Murine Models of Pancreatic Cancer. Cancer Biother Radiopharm (2015) 0.77

COX2 is involved in hypoxia-induced TNF-α expression in osteoblast. Sci Rep (2015) 0.77

EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis. Biol Reprod (2010) 0.77

Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats. Cell Mol Neurobiol (2014) 0.77

Difluoroboron β-Diketonate Materials with Long-Lived Phosphorescence Enable Lifetime Based Oxygen Imaging with a Portable Cost Effective Camera. Anal Methods (2016) 0.76

Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats. J Biomed Sci (2015) 0.76

OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep (2015) 0.76

Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms. J Hematol Oncol (2015) 0.76

TRP channels as sensors of oxygen availability. Pflugers Arch (2013) 0.75

Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications. Br J Radiol (2011) 0.75

Thermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approaches. PLoS One (2012) 0.75

Neuronal cell fate decisions:  O2 and CO2 sensing neurons require egl-13/Sox5. Worm (2013) 0.75

Nutrient and Metabolic Sensing in T Cell Responses. Front Immunol (2017) 0.75

Telomerase activity in pregnancy complications (Review). Mol Med Rep (2016) 0.75

A Genetically Encoded FRET Sensor for Hypoxia and Prolyl Hydroxylases. ACS Chem Biol (2016) 0.75

HIF-1α and growth plate development: what we really know. Bonekey Rep (2015) 0.75

Oxygen Sensing Difluoroboron β-Diketonate Polylactide Materials with Tunable Dynamic Ranges for Wound Imaging. ACS Sens (2016) 0.75

Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus Macaques. PLoS One (2016) 0.75

Update on the renal toxicity of iodinated contrast drugs used in clinical medicine. Drug Healthc Patient Saf (2017) 0.75

Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP. Proc Natl Acad Sci U S A (2017) 0.75

Endothelial cell metabolism in health and disease: impact of hypoxia. EMBO J (2017) 0.75

Articles cited by this

Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (1999) 23.45

The CBP co-activator is a histone acetyltransferase. Nature (1997) 10.91

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol (2000) 9.16

Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol (2004) 9.05

Purification and characterization of hypoxia-inducible factor 1. J Biol Chem (1995) 8.53

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev (1997) 8.51

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science (2002) 8.27

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12

Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer (2004) 7.91

Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev (2002) 7.08

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell (2004) 6.99

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev (2001) 6.35

Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (1997) 6.15

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A (1997) 6.11

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol (2003) 5.14

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med (2002) 5.10

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation (2000) 4.96

The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol (2000) 4.79

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A (2001) 4.60

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev (2001) 4.45

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature (1997) 4.36

TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell (2003) 4.13

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev (1998) 4.11

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem (2002) 3.91

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem (2003) 3.88

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell (2002) 3.86

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J (1999) 3.70

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem (1997) 3.67

Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol (2004) 3.63

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev (2001) 3.39

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res (2002) 2.97

Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol (2002) 2.90

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature (2001) 2.83

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr (1998) 2.82

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res (2001) 2.80

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61

Vascular-targeting therapies for treatment of malignant disease. Cancer (2004) 2.54

Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol (2003) 2.50

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21

Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985) (2003) 2.04

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol (2003) 1.99

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res (2004) 1.96

Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle (2004) 1.90

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell (2003) 1.85

HIF activation by pH-dependent nucleolar sequestration of VHL. Nat Cell Biol (2004) 1.79

O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J Appl Physiol (1985) (2004) 1.72

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem J (2002) 1.61

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J (2004) 1.53

Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J Mol Cell Cardiol (2000) 1.37

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer (1990) 1.23

Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood (2003) 1.22

Regulation of oxygen sensing by ion channels. J Appl Physiol (1985) (2004) 1.15

Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev (2004) 1.15

Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res (2001) 1.06

Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res (2004) 0.98

Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. Adv Exp Med Biol (2003) 0.97

Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Mol Cell Biol (2003) 0.97

O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens. Respir Physiol Neurobiol (2002) 0.96

A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis. Biol Reprod (2004) 0.96

Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar. J Biol Chem (2004) 0.95

Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle (2004) 0.93

O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide. Biol Chem (2004) 0.93

Oxygen-dependent signaling in pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol (2002) 0.92

Current paradigms in cellular oxygen sensing. Adv Exp Med Biol (2003) 0.90

Articles by these authors

(truncated to the top 100)

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev (2006) 5.15

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell (2008) 4.84

Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46

Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem (2003) 3.88

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61

Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell (2007) 2.58

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol (2006) 2.56

Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest (2009) 2.47

O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45

Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest (2003) 2.37

An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Res (2005) 2.07

Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol (2006) 1.87

HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A (2010) 1.86

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell (2003) 1.85

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81

Regulation of transcription and translation by hypoxia. Cancer Biol Ther (2004) 1.74

APOBEC3B deletion and risk of HIV-1 acquisition. J Infect Dis (2009) 1.74

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell (2012) 1.71

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem (2002) 1.70

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol (2005) 1.67

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61

HIFs, hypoxia, and vascular development. Curr Top Dev Biol (2004) 1.60

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59

Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res (2010) 1.57

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J Clin Invest (2007) 1.56

Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52

Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51

Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol (2010) 1.51

Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50

Reactive oxygen species and cellular oxygen sensing. Free Radic Biol Med (2007) 1.49

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest (2010) 1.46

Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov (2013) 1.44

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development (2005) 1.44

Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development (2004) 1.41

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest (2009) 1.40

Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther (2005) 1.38

The importance of PU.1 concentration in hematopoietic lineage commitment and maturation. Blood Cells Mol Dis (2003) 1.34

HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest (2013) 1.32

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med (2011) 1.31

Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31

Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res (2004) 1.30

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem (2006) 1.29

Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27

Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell (2005) 1.26

C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A (2002) 1.26

HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell (2006) 1.23

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem (2006) 1.22

Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol (2003) 1.21

In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res (2004) 1.20

pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol (2006) 1.18

Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia. Biomed Opt Express (2010) 1.18

BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol (2012) 1.17

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer Res (2013) 1.15

Effects of hypoxia and HIFs on cancer metabolism. Int J Hematol (2012) 1.13

Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer Res (2011) 1.12

Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol (2013) 1.08

Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res (2009) 1.08

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc Natl Acad Sci U S A (2013) 1.06

Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer. Clin Cancer Res (2013) 1.04

Metastasis and stem cell pathways. Cancer Metastasis Rev (2007) 1.04

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem (2003) 1.04

O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Mol Cell Biol (2011) 1.03

mir-210: a sensor for hypoxic stress during tumorigenesis. Mol Cell (2009) 1.01

Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J Appl Physiol (1985) (2004) 1.01

The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology. Cell Metab (2011) 0.99

From stem cells to cancer stem cells: HIF takes the stage. Curr Opin Cell Biol (2012) 0.99

Lasting longer without oxygen: The influence of hypoxia on Notch signaling. Cancer Cell (2005) 0.99

von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development (2010) 0.99

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol (2012) 0.97

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival. Cancer Biol Ther (2008) 0.95

Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection. J Immunol (2005) 0.95

Taking aim at translation for tumor therapy. J Clin Invest (2007) 0.94

Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J (2002) 0.94