Is the neutrophil the key effector cell in severe asthma?

PubWeight™: 1.06‹?› | Rank: Top 15%

🔗 View Article (PMC 1747453)

Published in Thorax on July 01, 2005

Authors

A V Kamath, I D Pavord, P R Ruparelia, E R Chilvers

Articles citing this

Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood (2006) 1.31

Macrophage heterogeneity in respiratory diseases. Mediators Inflamm (2013) 1.20

Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol (2009) 1.00

The Temporal Evolution of Airways Hyperresponsiveness and Inflammation. J Allergy Ther (2012) 0.94

Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. J Immunol (2008) 0.92

Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin Exp Immunol (2007) 0.92

Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma. Am J Pathol (2008) 0.88

Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol (2007) 0.88

Sputum IgE and cytokines in asthma: relationship with sputum cellular profile. PLoS One (2013) 0.87

Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol (2009) 0.85

Cough frequency in children with mild asthma correlates with sputum neutrophil count. Thorax (2006) 0.83

Imaging Inflammation in Asthma: Real Time, Differential Tracking of Human Neutrophil and Eosinophil Migration in Allergen Challenged, Atopic Asthmatics in Vivo. EBioMedicine (2014) 0.81

IL-13 overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood. Mutat Res (2014) 0.80

Neutrophil airway inflammation in childhood asthma. Thorax (2006) 0.79

Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture. Arterioscler Thromb Vasc Biol (2016) 0.77

Time sequence of airway remodeling in a mouse model of chronic asthma: the relation with airway hyperresponsiveness. J Korean Med Sci (2007) 0.77

Pathophysiological roles of microvascular alterations in pulmonary inflammatory diseases: possible implications of tumor necrosis factor-alpha and CXC chemokines. Int J Chron Obstruct Pulmon Dis (2008) 0.76

Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory? BMC Pulm Med (2016) 0.75

Biomarkers in the Management of Difficult Asthma. Curr Top Med Chem (2016) 0.75

Co-inhalation of roflumilast, rather than formoterol, with fluticasone more effectively improves asthma in asthmatic mice. Exp Biol Med (Maywood) (2017) 0.75

Articles by these authors

(truncated to the top 100)

Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes. Mol Microbiol (1996) 4.86

The use of induced sputum to investigate airway inflammation. Thorax (1997) 3.85

Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med (1999) 3.84

Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet (2000) 3.63

Non-eosinophilic corticosteroid unresponsive asthma. Lancet (1999) 3.25

Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem (2000) 3.17

A new perspective on concepts of asthma severity and control. Eur Respir J (2008) 3.16

Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Thorax (2003) 2.93

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med (1999) 2.92

Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur Respir J (2007) 2.78

Interaction and dose equivalence of salbutamol and salmeterol in patients with asthma. BMJ (1993) 2.70

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax (2002) 2.63

Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma. Lancet (1990) 2.52

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39

Dietary antioxidant vitamin intake and lung function in the general population. Am J Respir Crit Care Med (1995) 2.25

The Leicester Cough Monitor: preliminary validation of an automated cough detection system in chronic cough. Eur Respir J (2008) 2.01

Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD. Respiration (2009) 1.92

NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem (1999) 1.89

Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J (2000) 1.81

Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax (2005) 1.81

Spontaneous alpha-N-6-phosphogluconoylation of a "His tag" in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem (1999) 1.80

Multi-dimensional phenotyping: towards a new taxonomy for airway disease. Clin Exp Allergy (2005) 1.77

Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax (2003) 1.75

Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci (Lond) (1998) 1.69

Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood (1997) 1.63

New insights into the role of the mast cell in asthma. Clin Exp Allergy (2003) 1.61

Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation. Clin Exp Allergy (2005) 1.54

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Clin Exp Allergy (2011) 1.53

The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy (2005) 1.52

Expression of CCR8 is increased in asthma. Clin Exp Allergy (2010) 1.51

Respiratory symptoms in patients with treated hypothyroidism and inflammatory bowel disease. Thorax (2003) 1.51

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49

New insights into the relationship between airway inflammation and asthma. Clin Sci (Lond) (2002) 1.47

Leukotriene antagonists and symptom control in chronic persistent asthma. Lancet (2001) 1.46

Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy (2004) 1.46

Variability of bronchial inflammation in chronic obstructive pulmonary disease: implications for study design. Eur Respir J (2006) 1.45

Regulation of macrophage phagocytosis of apoptotic cells by cAMP. J Immunol (1998) 1.41

Hypoxia prolongs neutrophil survival in vitro. FEBS Lett (1995) 1.40

Time to extend 'the timetable of tuberculosis'? Respir Med (1994) 1.37

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res (1998) 1.37

Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy (2003) 1.37

Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay. Biochem J (1990) 1.34

Microbiological profile of community-acquired pneumonia in adults over the last 20 years. J Infect (2005) 1.33

Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis. Eur Respir J (2007) 1.30

Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax (1992) 1.27

Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease. Clin Exp Allergy (2005) 1.22

Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis. Thorax (2003) 1.19

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol (1999) 1.18

Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med (2000) 1.15

Asthma control during and after cessation of regular beta 2-agonist treatment. Am Rev Respir Dis (1993) 1.13

Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus. J Bacteriol (2001) 1.11

Priming differentially regulates neutrophil adhesion molecule expression/function. Immunology (1996) 1.10

Agents that elevate cAMP inhibit human neutrophil apoptosis. Biochem Biophys Res Commun (1995) 1.10

A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells. Biochem J (1996) 1.05

Prolonged survival of neutrophils from patients with Delta F508 CFTR mutations. Thorax (2008) 1.05

Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. Cell Signal (1999) 1.03

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets. Trends Pharmacol Sci (1999) 1.03

What can we learn from highly purified neutrophils? Biochem Soc Trans (2004) 1.03

Adenosine monophosphate and histamine induced bronchoconstriction: repeatability and protection by terbutaline. Thorax (1997) 1.02

Observational study of the natural history of eosinophilic bronchitis. Clin Exp Allergy (2005) 1.01

Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma. Eur Respir J (2000) 1.01

A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet. Thorax (2002) 1.00

Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: role in mediating airway smooth muscle proliferation. Mol Pharmacol (1998) 1.00

Sputum induction to assess airway inflammation: is it an inflammatory stimulus? Thorax (1998) 1.00

Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J (2005) 0.99

Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism. Biochem Pharmacol (2000) 0.98

Demonstration of reversible priming of human neutrophils using platelet-activating factor. Blood (1996) 0.97

Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants. Thorax (2002) 0.97

Effect of regular terbutaline and budesonide on bronchial reactivity to allergen challenge. Am J Respir Crit Care Med (1994) 0.97

A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture. Br J Pharmacol (1995) 0.96

Development of irreversible airflow obstruction in a patient with eosinophilic bronchitis without asthma. Eur Respir J (1999) 0.95

Systemic effects of salbutamol and salmeterol in patients with asthma. Thorax (1994) 0.95

The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults. Chest (2001) 0.95

Performance of CURB-65 and CURB-age in community-acquired pneumonia. Int J Clin Pract (2009) 0.95

Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Eur Respir J (2006) 0.94

Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells. Cancer Res (1996) 0.93

The safety and success rate of sputum induction using a low output ultrasonic nebuliser. Respir Med (1999) 0.92

Chronic tonsillar enlargement and cough: preliminary evidence of a novel and treatable cause of chronic cough. Eur Respir J (2004) 0.92

Role of neutrophil apoptosis in the resolution of pulmonary inflammation. Monaldi Arch Chest Dis (1999) 0.91

Miliary tuberculosis in Edinburgh--a comparison between 1984-1992 and 1954-1967. Respir Med (1994) 0.90

CRTH2 expression on T cells in asthma. Clin Exp Immunol (2010) 0.90

Prevalence of inflammatory bowel disease in patients with airways disease. Respir Med (2008) 0.89

Effects of S-salbutamol on human isolated bronchus. Pulm Pharmacol Ther (1998) 0.89

Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1. Clin Exp Allergy (2012) 0.89

Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells. Br J Pharmacol (1997) 0.89

Site-directed alteration of the active-site residues of histidine decarboxylase from Clostridium perfringens. Biochemistry (1990) 0.89

Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. Eur Respir J (2009) 0.89

Between-observer repeatability of sputum differential cell counts. Influence of cell viability and squamous cell contamination. Clin Exp Allergy (1999) 0.89

Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. Am J Respir Crit Care Med (2000) 0.88

Management of asthma in adults: current therapy and future directions. Postgrad Med J (2003) 0.88

Is it time to rethink the urea criterion in CURB-65? Eur Respir J (2006) 0.87

Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. Br J Pharmacol (1995) 0.87

Eosinophilic bronchitis - what is it and why is it important? Clin Exp Allergy (2000) 0.87

Enzyme-catalysed non-oxidative decarboxylation of aromatic acids: I. Purification and spectroscopic properties of 2,3 dihydroxybenzoic acid decarboxylase from Aspergillus niger. Biochem Biophys Res Commun (1987) 0.86

Beta-adrenoceptor induced inhibition of muscarinic receptor-stimulated phosphoinositide metabolism is agonist specific in bovine tracheal smooth muscle. Eur J Pharmacol (1991) 0.86

Mepolizumab in refractory eosinophilic asthma. Thorax (2010) 0.84

Inositol phosphates and airway smooth muscle. Pulm Pharmacol (1989) 0.84

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils. Biochem Soc Trans (2004) 0.84

Objective quantitative analysis of eosinophils and bronchial epithelial cells in induced sputum by laser scanning cytometry. Thorax (1999) 0.83

Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices. Naunyn Schmiedebergs Arch Pharmacol (1989) 0.83