Published in Eur J Immunol on August 01, 2005
Function, structure and therapeutic potential of complement C5a receptors. Br J Pharmacol (2007) 2.25
Complement 5a receptor inhibition improves renal allograft survival. J Am Soc Nephrol (2008) 1.72
Macrophages and immunologic inflammation of the kidney. Semin Nephrol (2010) 1.71
Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation (2009) 1.56
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
Mechanisms of tissue injury in lupus nephritis. Arthritis Res Ther (2011) 1.31
Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol (2010) 1.16
Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J Neurochem (2010) 1.16
Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol (2013) 1.13
Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest (2012) 1.09
C5a alters blood-brain barrier integrity in experimental lupus. FASEB J (2010) 1.06
Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes. J Immunol (2011) 1.00
Urokinase and its receptors in chronic kidney disease. Front Biosci (2008) 0.94
Molecules Great and Small: The Complement System. Clin J Am Soc Nephrol (2015) 0.91
Leukocytes in glomerular injury. Semin Immunopathol (2007) 0.90
Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum. Infect Immun (2014) 0.89
Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Arthritis Res Ther (2011) 0.87
Neutrophils: game changers in glomerulonephritis? Trends Mol Med (2010) 0.86
Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol (2010) 0.85
C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse. Mol Immunol (2009) 0.83
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cell Mol Immunol (2015) 0.83
Markers of childhood lupus nephritis indicating disease activity. Pediatr Nephrol (2010) 0.80
Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection. PLoS Pathog (2015) 0.78
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology (2009) 0.77
Novel targets for immunotherapy in glomerulonephritis. Biologics (2008) 0.77
N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus. Am J Physiol Renal Physiol (2015) 0.77
Anticomplement therapy. Biologics (2008) 0.76
C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS One (2016) 0.75
Complement in Lupus Nephritis: New Perspectives. Kidney Dis (Basel) (2015) 0.75
Current and Emerging Therapies for Lupus Nephritis. J Am Soc Nephrol (2016) 0.75
Molecular imaging of the kidney in lupus nephritis to characterize response to treatment. Transl Res (2016) 0.75
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med (2008) 9.87
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int (2009) 7.45
The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int (2009) 7.19
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe (2011) 5.06
Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53
Pathologic classification of diabetic nephropathy. J Am Soc Nephrol (2010) 3.61
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Structure of C3b reveals conformational changes that underlie complement activity. Nature (2006) 3.22
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
C3 glomerulopathy: consensus report. Kidney Int (2013) 2.85
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A (2002) 2.76
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J (2008) 2.75
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62
Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol (2005) 2.58
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Complement and coagulation: strangers or partners in crime? Trends Immunol (2007) 2.48
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A (2008) 2.42
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest (2003) 2.39
The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med (2003) 2.38
Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy. Am J Transplant (2004) 2.22
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology (2005) 2.18
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults. Kidney Int (2010) 2.14
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. J Immunol (2006) 2.13
Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J Immunol (2013) 2.10
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med (2005) 2.09
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood (2010) 2.08
Pros and cons for C4d as a biomarker. Kidney Int (2012) 2.03
Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98
Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol (2002) 1.96
A structural basis for complement inhibition by Staphylococcus aureus. Nat Immunol (2007) 1.95
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol (2012) 1.93
Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol (2010) 1.83
Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol (2004) 1.82
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem (2006) 1.72
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem (2007) 1.71
ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation (2009) 1.71
Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. J Am Soc Nephrol (2003) 1.68
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood (2003) 1.68
Immunotactoid keratopathy: a clinicopathologic case report and a review of reports of corneal involvement in systemic paraproteinemias. Surv Ophthalmol (2004) 1.67
The role of complement in biomaterial-induced inflammation. Mol Immunol (2006) 1.67
Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol (2008) 1.66
Interaction between the coagulation and complement system. Adv Exp Med Biol (2008) 1.65
The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol (2010) 1.64
Complement in immune and inflammatory disorders: therapeutic interventions. J Immunol (2013) 1.64
Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science (2010) 1.59
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology (2004) 1.58
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56
Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int (2009) 1.56
Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J Immunol (2003) 1.56
Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood (2014) 1.55
In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol (2010) 1.54
Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell (2011) 1.54
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci U S A (2009) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet (2009) 1.52
The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int (2012) 1.52
Experimental membranous nephropathy redux. Am J Physiol Renal Physiol (2005) 1.52
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
Treatment of glomerulonephritis: will we ever have options other than steroids and cytotoxics? Kidney Int (2005) 1.51
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. J Immunol (2004) 1.48
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci (2008) 1.47
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol (2002) 1.45
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol (2007) 1.45
Protection of innate immunity by C5aR antagonist in septic mice. FASEB J (2002) 1.44
Anti-vascular endothelial growth factor receptor-2 antibody accelerates renal disease in the NZB/W F1 murine systemic lupus erythematosus model. Clin Cancer Res (2005) 1.44
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood (2010) 1.44
Successful retransplantation after renal allograft loss to polyoma virus interstitial nephritis. Transplantation (2002) 1.43
Complement in inflammatory tissue damage and disease. Trends Immunol (2002) 1.43
Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol (2009) 1.40
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology (2012) 1.39
Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol (2009) 1.38
Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37
Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol (2004) 1.36
Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol (2012) 1.35
TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int (2007) 1.34
Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol (2009) 1.33
Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Mol Immunol (2004) 1.32
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus. J Biol Chem (2007) 1.32
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. J Immunol (2012) 1.30
Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol (2004) 1.29