Published in Nat Immunol on March 11, 2007
Complement evasion by human pathogens. Nat Rev Microbiol (2008) 4.24
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03
A structure-based benchmark for protein-protein binding affinity. Protein Sci (2011) 1.81
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol (2008) 1.66
Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat Rev Microbiol (2010) 1.52
Staphylococcus aureus toxins. Curr Opin Microbiol (2013) 1.46
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood (2010) 1.44
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42
Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37
The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b. PLoS Pathog (2008) 1.34
Complement System Part II: Role in Immunity. Front Immunol (2015) 1.31
The Staphylococcus aureus extracellular adherence protein (Eap) adopts an elongated but structured conformation in solution. Protein Sci (2007) 1.18
Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications. J Mol Med (Berl) (2010) 1.18
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J Immunol (2009) 1.16
Validation of macromolecular flexibility in solution by small-angle X-ray scattering (SAXS). Eur Biophys J (2012) 1.13
Local inflammation induces complement crosstalk which amplifies the antimicrobial response. PLoS Pathog (2009) 1.10
Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Protein Sci (2008) 1.09
Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. J Immunol (2008) 1.07
Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure. Proteins (2012) 1.05
Operon structure of Staphylococcus aureus. Nucleic Acids Res (2010) 1.04
Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. PLoS Pathog (2013) 1.02
Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence. J Biol Chem (2011) 0.99
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. PLoS One (2012) 0.98
Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family. J Biol Chem (2011) 0.96
Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi. J Biol Chem (2008) 0.96
Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy. Immunobiology (2012) 0.93
Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein. J Biol Chem (2010) 0.93
Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. PLoS One (2012) 0.91
Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation. FASEB J (2013) 0.89
Humoral innate immune response and disease. Clin Immunol (2012) 0.89
Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry. J Am Soc Mass Spectrom (2008) 0.89
The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase. J Immunol (2014) 0.88
Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals. Protein Sci (2014) 0.88
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins. Adv Exp Med Biol (2012) 0.88
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J Mol Biol (2010) 0.88
Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry. Mol Immunol (2008) 0.86
Molecular analysis of the interaction between staphylococcal virulence factor Sbi-IV and complement C3d. Biophys J (2014) 0.83
Contribution of follicular dendritic cells to persistent HIV viremia. J Virol (2013) 0.83
MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence. Sci Rep (2015) 0.83
A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d. Mol Immunol (2010) 0.82
A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins. J Biol Chem (2012) 0.81
The production of extracellular proteins is regulated by ribonuclease III via two different pathways in Staphylococcus aureus. PLoS One (2011) 0.81
The giant protein Ebh is a determinant of Staphylococcus aureus cell size and complement resistance. J Bacteriol (2013) 0.80
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog (2016) 0.80
A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces. Int J Mol Sci (2016) 0.80
Novel Evasion Mechanisms of the Classical Complement Pathway. J Immunol (2016) 0.80
Energetic evaluation of binding modes in the C3d and Factor H (CCP 19-20) complex. Protein Sci (2015) 0.79
Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice. Infect Immun (2016) 0.78
Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection. J Biol Chem (2012) 0.78
Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunol Rev (2016) 0.78
Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex. Proteins (2010) 0.77
Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. J Immunol (2015) 0.76
Application of the C3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection. PLoS One (2015) 0.76
Structural Implications for the Formation and Function of the Complement Effector Protein iC3b. J Immunol (2017) 0.76
Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif. MBio (2016) 0.76
Coarse-Grained Conformational Sampling of Protein Structure Improves the Fit to Experimental Hydrogen-Exchange Data. Front Mol Biosci (2017) 0.75
A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo. Microb Biotechnol (2017) 0.75
Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes. J Biol Chem (2015) 0.75
Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics. J Immunol (2017) 0.75
Let's Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse. Front Microbiol (2017) 0.75
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe (2011) 5.06
Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53
Complement evasion by human pathogens. Nat Rev Microbiol (2008) 4.24
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Structure of C3b reveals conformational changes that underlie complement activity. Nature (2006) 3.22
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A (2002) 2.76
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Complement and coagulation: strangers or partners in crime? Trends Immunol (2007) 2.48
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest (2003) 2.39
The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med (2003) 2.38
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology (2005) 2.18
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. J Immunol (2006) 2.13
Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J Immunol (2013) 2.10
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med (2005) 2.09
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood (2010) 2.08
Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98
Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol (2010) 1.83
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem (2006) 1.72
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem (2007) 1.71
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood (2003) 1.68
The role of complement in biomaterial-induced inflammation. Mol Immunol (2006) 1.67
Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol (2008) 1.66
Interaction between the coagulation and complement system. Adv Exp Med Biol (2008) 1.65
The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol (2010) 1.64
Complement in immune and inflammatory disorders: therapeutic interventions. J Immunol (2013) 1.64
Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science (2010) 1.59
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology (2004) 1.58
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56
Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J Immunol (2003) 1.56
Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood (2014) 1.55
Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell (2011) 1.54
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci U S A (2009) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet (2009) 1.52
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. J Immunol (2004) 1.48
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci (2008) 1.47
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol (2007) 1.45
Protection of innate immunity by C5aR antagonist in septic mice. FASEB J (2002) 1.44
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood (2010) 1.44
Complement in inflammatory tissue damage and disease. Trends Immunol (2002) 1.43
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology (2012) 1.39
Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37
Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol (2004) 1.36
Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol (2012) 1.35
Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol (2009) 1.33
Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Mol Immunol (2004) 1.32
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus. J Biol Chem (2007) 1.32
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. J Immunol (2012) 1.30
Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol (2004) 1.29
Complement: more than a 'guard' against invading pathogens? Trends Immunol (2002) 1.28
Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition? Trends Immunol (2010) 1.28
Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem (2005) 1.28
Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity. J Am Chem Soc (2003) 1.28
Complexity of complement activation in sepsis. J Cell Mol Med (2008) 1.26
Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface. Biomaterials (2005) 1.25
Recent developments in low molecular weight complement inhibitors. Mol Immunol (2009) 1.23