Published in J Mol Biol on January 12, 2008
Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol (2010) 4.29
HIV-1 assembly, budding, and maturation. Cold Spring Harb Perspect Med (2012) 3.17
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell (2009) 1.57
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell (2008) 1.46
Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol Biol Cell (2010) 1.43
Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition. J Biol Chem (2010) 1.08
Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta (2011) 1.07
Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. Mol Biol Cell (2010) 1.06
Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation. J Cell Biol (2014) 1.05
Regulation of Vps4 during MVB sorting and cytokinesis. Traffic (2011) 1.04
Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. Structure (2010) 1.03
Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nat Struct Mol Biol (2015) 1.03
Receiver domains control the active-state stoichiometry of Aquifex aeolicus sigma54 activator NtrC4, as revealed by electrospray ionization mass spectrometry. J Mol Biol (2009) 1.01
Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB. PLoS One (2011) 0.98
The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol (2013) 0.95
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway. J Biol Chem (2012) 0.95
Reverse-topology membrane scission by the ESCRT proteins. Nat Rev Mol Cell Biol (2016) 0.90
Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly. J Struct Biol (2012) 0.89
Assembly and disassembly of the ESCRT-III membrane scission complex. FEBS Lett (2011) 0.89
Vesicle formation within endosomes: An ESCRT marks the spot. Commun Integr Biol (2012) 0.88
Electron tomography of HIV-1 infection in gut-associated lymphoid tissue. PLoS Pathog (2014) 0.88
Wrapping up the bad news: HIV assembly and release. Retrovirology (2013) 0.88
25 years of HIV research on virology, virus restriction, immunopathogenesis, genes and vaccines. Clin Exp Immunol (2008) 0.86
Regulation of Vps4 ATPase activity by ESCRT-III. Biochem Soc Trans (2009) 0.84
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem (2015) 0.83
The linker region plays a regulatory role in assembly and activity of the Vps4 AAA ATPase. J Biol Chem (2013) 0.82
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol (2015) 0.82
Asymmetric ring structure of Vps4 required for ESCRT-III disassembly. Nat Commun (2015) 0.80
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife (2017) 0.79
Neuronal Functions of ESCRTs. Exp Neurobiol (2012) 0.77
Structure of glutaraldehyde cross-linked ryanodine receptor. J Struct Biol (2013) 0.76
The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells. J Mol Histol (2010) 0.76
NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway. Sci Rep (2016) 0.75
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol (2006) 14.70
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
The protein network of HIV budding. Cell (2003) 7.82
AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol (2005) 7.73
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature (1997) 7.33
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell (2003) 6.69
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science (2007) 6.13
The emerging shape of the ESCRT machinery. Nat Rev Mol Cell Biol (2007) 6.05
AAA+ superfamily ATPases: common structure--diverse function. Genes Cells (2001) 5.83
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. EMBO J (1997) 5.05
Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell (2004) 4.90
Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
The structures of HsIU and the ATP-dependent protease HsIU-HsIV. Nature (2000) 4.46
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A (2003) 4.21
AAA proteins. Lords of the ring. J Cell Biol (2000) 3.89
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA. Nature (1999) 3.84
ESCRT-III recognition by VPS4 ATPases. Nature (2007) 3.64
N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. J Cell Biol (1994) 3.59
Dynamics of substrate denaturation and translocation by the ClpXP degradation machine. Mol Cell (2000) 3.52
Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL. Nature (1997) 3.48
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4. Nature (2007) 3.47
Structure of the AAA ATPase p97. Mol Cell (2000) 3.37
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell (2007) 3.06
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol (2003) 2.93
The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell (2003) 2.89
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell (2005) 2.69
Structural and mechanistic studies of VPS4 proteins. EMBO J (2005) 2.58
Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP. Proc Natl Acad Sci U S A (2000) 2.56
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol (2005) 2.31
Crystal and solution structures of an HslUV protease-chaperone complex. Cell (2000) 2.29
Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae. Traffic (2004) 2.24
The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release. J Virol (2003) 2.19
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol (2006) 2.18
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc Natl Acad Sci U S A (2005) 2.12
AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett (2002) 2.10
Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP. Nat Struct Biol (1998) 2.05
Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. Structure (2001) 2.02
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem (2002) 1.97
Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site. J Virol (2007) 1.93
Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell (2007) 1.82
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome. Nat Struct Biol (1997) 1.81
The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum Mol Genet (2004) 1.77
Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci (2003) 1.73
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem (2005) 1.73
Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A (2006) 1.66
Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem (2003) 1.64
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
Late domain-dependent inhibition of equine infectious anemia virus budding. J Virol (2004) 1.57
25 Angstrom resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring. J Mol Biol (2004) 1.55
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (2005) 1.53
Each domain of the N-ethylmaleimide-sensitive fusion protein contributes to its transport activity. J Biol Chem (1995) 1.53
ClpA mediates directional translocation of substrate proteins into the ClpP protease. Proc Natl Acad Sci U S A (2001) 1.51
Group II chaperonins: new TRiC(k)s and turns of a protein folding machine. J Mol Biol (1999) 1.50
Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J (2006) 1.48
Translocation pathway of protein substrates in ClpAP protease. Proc Natl Acad Sci U S A (2001) 1.47
Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model. J Mol Biol (2003) 1.36
GroEL/GroES: structure and function of a two-stroke folding machine. J Struct Biol (1998) 1.34
Improved methods for determination of rotational symmetries in macromolecules. Ultramicroscopy (1995) 1.26
Clamp loaders and replication initiation. Curr Opin Struct Biol (2006) 1.25
N-ethylmaleimide sensitive factor (NSF) structure and function. Int Rev Cytol (2001) 1.21
Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. EMBO J (2003) 1.20
Nucleotide-induced switch in oligomerization of the AAA+ ATPase ClpB. Protein Sci (2004) 1.17
The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease. J Struct Biol (2004) 1.13
VAT, the thermoplasma homolog of mammalian p97/VCP, is an N domain-regulated protein unfoldase. J Biol Chem (2005) 1.13
Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol (2007) 1.11
Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits. Proc Natl Acad Sci U S A (1999) 1.10
Two different oligomeric states of the RuvB branch migration motor protein as revealed by electron microscopy. J Struct Biol (2000) 1.09
Functional domains of Brevibacillus thermoruber lon protease for oligomerization and DNA binding: role of N-terminal and sensor and substrate discrimination domains. J Biol Chem (2004) 1.01
Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution. J Struct Biol (2004) 0.99
Mg2+-linked oligomerization modulates the catalytic activity of the Lon (La) protease from Mycobacterium smegmatis. Biochemistry (2001) 0.91
Electron cryo-microscopy of VAT, the archaeal p97/CDC48 homologue from Thermoplasma acidophilum. J Mol Biol (2002) 0.88
The protein network of HIV budding. Cell (2003) 7.82
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A (2006) 6.82
Ubiquitin-binding domains. Nat Rev Mol Cell Biol (2005) 6.77
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol (2002) 5.20
Functional surfaces of the human immunodeficiency virus type 1 capsid protein. J Virol (2003) 4.47
Magnetosomes are cell membrane invaginations organized by the actin-like protein MamK. Science (2005) 4.19
An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe (2007) 4.17
X-ray structures of the hexameric building block of the HIV capsid. Cell (2009) 4.08
The structural biology of HIV assembly. Curr Opin Struct Biol (2008) 3.71
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
ESCRT-III recognition by VPS4 ATPases. Nature (2007) 3.64
The structure of FtsZ filaments in vivo suggests a force-generating role in cell division. EMBO J (2007) 3.44
Location and architecture of the Caulobacter crescentus chemoreceptor array. Mol Microbiol (2008) 3.41
Mechanisms of enveloped RNA virus budding. Trends Cell Biol (2002) 3.36
Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells. EMBO J (2007) 3.17
Assembly properties of the human immunodeficiency virus type 1 CA protein. J Virol (2004) 3.09
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell (2007) 3.06
A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter. Cell (2008) 3.02
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors. Trends Cell Biol (2005) 2.73
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol Cell (2005) 2.68
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nat Struct Biol (2002) 2.66
ESCRT-III protein requirements for HIV-1 budding. Cell Host Microbe (2011) 2.61
Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography. Mol Microbiol (2006) 2.59
Structural and mechanistic studies of VPS4 proteins. EMBO J (2005) 2.58
Universal architecture of bacterial chemoreceptor arrays. Proc Natl Acad Sci U S A (2009) 2.50
General protein diffusion barriers create compartments within bacterial cells. Cell (2012) 2.48
Structure and functional interactions of the Tsg101 UEV domain. EMBO J (2002) 2.40
Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A (2010) 2.40
UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci (2011) 2.38
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. J Cell Biol (2003) 2.38
Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J Virol (2004) 2.37
Molecular organization of Gram-negative peptidoglycan. Proc Natl Acad Sci U S A (2008) 2.33
Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J Virol (2008) 2.30
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc Natl Acad Sci U S A (2002) 2.19
Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem (2003) 2.19
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe (2007) 2.18
Ubiquitin recognition by the human TSG101 protein. Mol Cell (2004) 2.17
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc Natl Acad Sci U S A (2005) 2.12
Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography. J Mol Biol (2004) 2.10
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
The metabolic enzyme CTP synthase forms cytoskeletal filaments. Nat Cell Biol (2010) 2.01
Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol (2009) 1.98
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem (2004) 1.92
ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A (2008) 1.91
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A (2010) 1.89
Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins. Proc Natl Acad Sci U S A (2012) 1.89
Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus. J Virol (2005) 1.88
Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell (2007) 1.85
Fully automated, sequential tilt-series acquisition with Leginon. J Struct Biol (2009) 1.84
Electron cryotomography sample preparation using the Vitrobot. Nat Protoc (2006) 1.83
An improved cryogen for plunge freezing. Microsc Microanal (2008) 1.82
In situ structure of the complete Treponema primitia flagellar motor. Nature (2006) 1.82
Crystal structure of the middle and C-terminal domains of the flagellar rotor protein FliG. EMBO J (2002) 1.79
The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition. Mol Cell (2006) 1.78
Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol (2007) 1.78
Structural insights into the catalytic mechanism of cyclophilin A. Nat Struct Biol (2003) 1.78
Potent D-peptide inhibitors of HIV-1 entry. Proc Natl Acad Sci U S A (2007) 1.76
Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV. Nat Struct Mol Biol (2007) 1.76
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem (2005) 1.73
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
3-D ultrastructure of O. tauri: electron cryotomography of an entire eukaryotic cell. PLoS One (2007) 1.72
Virus budding and the ESCRT pathway. Cell Host Microbe (2013) 1.70
Crystal structure of the flagellar rotor protein FliN from Thermotoga maritima. J Bacteriol (2005) 1.65
Structural diversity of bacterial flagellar motors. EMBO J (2011) 1.63
The structure of isolated Synechococcus strain WH8102 carboxysomes as revealed by electron cryotomography. J Mol Biol (2007) 1.63
Novel ultrastructures of Treponema primitia and their implications for motility. Mol Microbiol (2008) 1.63
Proteasome activators. Mol Cell (2011) 1.62
FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature (2008) 1.62
NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol (2008) 1.60
The helical MreB cytoskeleton in Escherichia coli MC1000/pLE7 is an artifact of the N-Terminal yellow fluorescent protein tag. J Bacteriol (2012) 1.58
Three-dimensional structure of the M-MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly. EMBO J (2003) 1.58
Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell (2009) 1.57
Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography. J Struct Biol (2008) 1.52
DipM, a new factor required for peptidoglycan remodelling during cell division in Caulobacter crescentus. Mol Microbiol (2010) 1.52
The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformation. EMBO J (2003) 1.50
Organization, structure, and assembly of alpha-carboxysomes determined by electron cryotomography of intact cells. J Mol Biol (2009) 1.50
Toward a biomechanical understanding of whole bacterial cells. Annu Rev Biochem (2008) 1.49
A comparison of liquid nitrogen and liquid helium as cryogens for electron cryotomography. J Struct Biol (2006) 1.47
Structural biology of the proteasome. Annu Rev Biophys (2013) 1.42
Observations on the behavior of vitreous ice at approximately 82 and approximately 12 K. J Struct Biol (2006) 1.41
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278). Biochemistry (2006) 1.41