Published in Toxicol Sci on September 08, 2005
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog (2011) 2.30
Mouse models for the study of colon carcinogenesis. Carcinogenesis (2008) 2.10
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis (2010) 1.15
Pathology of rodent models of intestinal cancer: progress report and recommendations. Gastroenterology (2013) 1.12
TLR4 activates the β-catenin pathway to cause intestinal neoplasia. PLoS One (2013) 1.10
Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon. J Biomed Opt (2010) 1.05
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Mol Carcinog (2010) 1.00
Animal models of colorectal cancer. Cancer Metastasis Rev (2013) 0.99
Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett (2008) 0.97
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem (2008) 0.96
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. Cancer Metastasis Rev (2011) 0.95
Cancer in inflammatory bowel disease: lessons from animal models. Curr Opin Gastroenterol (2012) 0.93
Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice. BMC Med Genomics (2012) 0.92
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia (2008) 0.91
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer. Int J Cancer (2011) 0.89
Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography. Cancer Growth Metastasis (2015) 0.82
Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. Int J Exp Pathol (2010) 0.82
Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials. PLoS One (2012) 0.81
Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross. G3 (Bethesda) (2012) 0.80
Impact of the Mdm2(SNP309-G) allele on a murine model of colorectal cancer. Oncogene (2014) 0.78
Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice. World J Gastroenterol (2011) 0.77
Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years. Cold Spring Harb Protoc (2015) 0.76
Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. PLoS One (2013) 0.76
Cripto haploinsufficiency affects in vivo colon tumor development. Int J Oncol (2014) 0.75
High-fat diets rich in saturated fat protect against azoxymethane/dextran sulfate sodium-induced colon cancer. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure. Sci Rep (2017) 0.75
Mitochondrial DNA Integrity is Maintained by APE1 in Carcinogen-induced Colorectal Cancer. Mol Cancer Res (2017) 0.75
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet (2005) 10.03
Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res (2006) 4.15
Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology (2003) 4.10
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mamm Genome (2008) 3.52
EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell (2012) 3.19
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome (2007) 2.82
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A (2002) 2.65
Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics (2004) 2.59
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Mol Cell Biol (2006) 2.12
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest (2008) 2.11
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci (2004) 1.82
Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations. Genetics (2005) 1.80
Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. J Appl Physiol (1985) (2010) 1.76
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med (2005) 1.70
Genetics of dark skin in mice. Genes Dev (2003) 1.68
EGFR signaling promotes TGFβ-dependent renal fibrosis. J Am Soc Nephrol (2011) 1.64
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice. Environ Health Perspect (2010) 1.60
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res (2009) 1.60
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol (2003) 1.58
The EGFR is required for proper innervation to the skin. J Invest Dermatol (2008) 1.55
Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol (2006) 1.52
Ten years of the collaborative cross. G3 (Bethesda) (2012) 1.50
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A (2012) 1.48
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem (2011) 1.48
Phosphatidylinositol 3-kinase signaling determines kidney size. J Clin Invest (2015) 1.46
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med (2011) 1.46
Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. Mamm Genome (2006) 1.44
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog (2013) 1.43
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med (2012) 1.39
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther (2010) 1.38
Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics (2006) 1.37
Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis (2009) 1.36
Genetic analysis of hematological parameters in incipient lines of the collaborative cross. G3 (Bethesda) (2012) 1.35
Biodegradation of Inion fast-absorbing biodegradable plates and screws. J Craniofac Surg (2008) 1.35
Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice. G3 (Bethesda) (2012) 1.35
Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene. Cancer Res (2005) 1.34
Status and access to the Collaborative Cross population. Mamm Genome (2012) 1.32
Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (2007) 1.29
Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice. Cancer Res (2006) 1.27
Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol (2004) 1.26
Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res (2007) 1.20
Architecture of energy balance traits in emerging lines of the Collaborative Cross. Am J Physiol Endocrinol Metab (2011) 1.20
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest (2009) 1.20
Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome (2004) 1.16
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. J Biol Chem (2010) 1.16
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci (2009) 1.11
Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome. Genetics (2007) 1.10
Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes Dev (2009) 1.10
Inhibition of retinal neovascularization by soluble EphA2 receptor. Exp Eye Res (2005) 1.10
The Collaborative Cross as a resource for modeling human disease: CC011/Unc, a new mouse model for spontaneous colitis. Mamm Genome (2014) 1.09
A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys. Bone (2010) 1.08
Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage. Cancer Res (2007) 1.05
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest (2013) 1.03
Murine models of colorectal cancer. Mamm Genome (2009) 1.03
Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics (2010) 1.02
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci (2010) 1.00
Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution. J Clin Invest (2014) 1.00
Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies. Cancer Cell (2004) 0.99
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol (2009) 0.99
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci (2010) 0.99
Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. J Bone Miner Res (2011) 0.97
Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Exp Cell Res (2005) 0.95
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicol Appl Pharmacol (2008) 0.95
The gastrointestinal microbiome: a malleable, third genome of mammals. Mamm Genome (2009) 0.95
Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. J Am Soc Nephrol (2010) 0.94
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC Genomics (2014) 0.94
Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome (2009) 0.92
Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. Mamm Genome (2011) 0.89
Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol Cancer Res (2009) 0.89
Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression. Clin Exp Metastasis (2010) 0.88
Modeling cancer patient populations in mice: complex genetic and environmental factors. Drug Discov Today Dis Models (2008) 0.87
Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis. Mamm Genome (2008) 0.87
Enhanced oligonucleotide microarray labeling and hybridization. Biotechniques (2006) 0.86
Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology (2009) 0.86
Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics (2009) 0.86
Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genet (2010) 0.86
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res (2009) 0.86
Human epithelial-specific response to pathogenic Campylobacter jejuni. FEMS Microbiol Lett (2006) 0.85
Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia. J Neurodev Disord (2009) 0.85
Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clin Exp Metastasis (2010) 0.85
Parent-of-origin effects on cardiac response to pressure overload in mice. Am J Physiol Heart Circ Physiol (2009) 0.84
Metastatic potential as a heritable trait. Nat Genet (2005) 0.84
Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. Environ Health Perspect (2009) 0.84
Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. J Natl Cancer Inst (2013) 0.84
Down's syndrome: paradox of a tumour repressor. Nature (2008) 0.83
MicroRNA expression in the livers of inbred mice. Mutat Res (2011) 0.83
Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.83
Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab (2008) 0.82
Bayesian hierarchical modeling for time course microarray experiments. Biometrics (2007) 0.82
Activin receptor signaling: a potential therapeutic target for osteoporosis. Curr Mol Pharmacol (2012) 0.81