Published in Gastroenterology on November 10, 2011
Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. J Physiol (2015) 0.91
Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis. Inflamm Bowel Dis (2013) 0.87
Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol (2013) 0.85
Regulatory-auxiliary subunits of CLC chloride channel-transport proteins. J Physiol (2015) 0.81
Gating the glutamate gate of CLC-2 chloride channel by pore occupancy. J Gen Physiol (2015) 0.79
Lubiprostone in constipation: clinical evidence and place in therapy. Ther Adv Chronic Dis (2015) 0.78
Identification and characterization of the zebrafish ClC-2 chloride channel orthologs. Pflugers Arch (2014) 0.78
Opioid-induced constipation: advances and clinical guidance. Ther Adv Chronic Dis (2016) 0.78
Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short-chain fatty acids. Pflugers Arch (2013) 0.77
May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci (2012) 0.76
Chloride channelopathies of ClC-2. Int J Mol Sci (2013) 0.76
Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome. Mol Cell Pediatr (2016) 0.75
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
Luminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents. Front Pharmacol (2017) 0.75
CFTR as a cAMP-dependent regulator of sodium channels. Science (1995) 6.50
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science (1991) 5.82
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet (1998) 3.96
A chloride channel widely expressed in epithelial and non-epithelial cells. Nature (1992) 3.60
Ion transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit current. Am J Physiol (1971) 3.47
Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science (1983) 3.31
Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev (2002) 3.10
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor. Nat Genet (1996) 2.65
Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev (1999) 2.60
Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (1992) 2.36
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol (2004) 2.33
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Expression and function of epithelial anoctamins. J Biol Chem (2010) 1.95
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. EMBO J (2001) 1.86
Expression of the chloride channel ClC-2 in the murine small intestine epithelium. Am J Physiol Cell Physiol (2000) 1.75
Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology (1988) 1.75
The TMEM16 protein family: a new class of chloride channels? Biophys J (2009) 1.68
Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology (2009) 1.59
Association between Hsp90 and the ClC-2 chloride channel upregulates channel function. Am J Physiol Cell Physiol (2005) 1.56
Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol (2008) 1.54
Cholinergic ion secretion in human colon requires coactivation by cAMP. Am J Physiol (1998) 1.48
Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am J Physiol Cell Physiol (2002) 1.44
Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem (2002) 1.34
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif. J Cell Sci (2005) 1.33
Role of CFTR in the colon. Annu Rev Physiol (2000) 1.31
Submucosal plexus and electrolyte transport across rat colonic mucosa. J Physiol (1985) 1.30
Sodium-dependent chloride secretion across rabbit descending colon. Am J Physiol (1983) 1.28
Evidence against direct activation of chloride secretion by carbachol in the rat distal colon. Eur J Pharmacol (1995) 1.21
Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells. Proc Natl Acad Sci U S A (1998) 1.19
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride. Gastroenterology (2004) 1.15
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4. J Physiol (2007) 1.11
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol (2006) 1.01
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models. J Biol Chem (2004) 0.99
Early aldosterone effect in distal colon by transcriptional regulation of ENaC subunits. Am J Physiol Gastrointest Liver Physiol (2000) 0.97
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization. Am J Physiol Gastrointest Liver Physiol (2002) 0.93
ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction. Am J Physiol Gastrointest Liver Physiol (2010) 0.93
Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem (2007) 0.90
Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 release. Exp Physiol (2000) 0.83
Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. J Cell Physiol (2009) 0.82
Basolateral K-Cl cotransporter regulates colonic potassium absorption in potassium depletion. J Biol Chem (2000) 0.81
CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells. Am J Physiol (1995) 0.81
Na(+)-dependent fluid absorption in intact perfused rat colonic crypts. Gastroenterology (2001) 0.78
Simultaneous measurements of 22Na and 36Cl in aqueous samples: a comparison of three different methods. Am J Physiol (1987) 0.78
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature (2010) 10.04
PATRIC, the bacterial bioinformatics database and analysis resource. Nucleic Acids Res (2013) 7.63
Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet (2004) 4.95
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (2011) 4.76
PATRIC: the comprehensive bacterial bioinformatics resource with a focus on human pathogenic species. Infect Immun (2011) 4.57
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science (2010) 4.52
Leaf nitrogen and phosphorus stoichiometry across 753 terrestrial plant species in China. New Phytol (2005) 4.20
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther (2003) 3.48
Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction (2010) 3.26
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest (2006) 3.25
Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy. Circulation (2004) 3.12
Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China. Vet Microbiol (2013) 3.05
New variant of porcine epidemic diarrhea virus, United States, 2014. Emerg Infect Dis (2014) 2.99
Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina. Opt Express (2005) 2.97
Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol (2007) 2.96
Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int (2008) 2.95
CanPredict: a computational tool for predicting cancer-associated missense mutations. Nucleic Acids Res (2007) 2.86
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci U S A (2009) 2.84
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet (2010) 2.74
Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. Radiology (2005) 2.69
Distinguishing cancer-associated missense mutations from common polymorphisms. Cancer Res (2007) 2.57
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53
Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985) (2007) 2.52
Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res (2008) 2.44
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res (2008) 2.38
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation (2010) 2.35
The yak genome and adaptation to life at high altitude. Nat Genet (2012) 2.34
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052. Hepatology (2012) 2.29
Structure-function-folding relationship in a WW domain. Proc Natl Acad Sci U S A (2006) 2.28
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med (2012) 2.27
Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction. Opt Express (2008) 2.26
Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc Natl Acad Sci U S A (2005) 2.23
Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defense. Curr Biol (2007) 2.20
Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value. J Am Coll Cardiol (2003) 2.20
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int (2010) 2.18
Development of an integrated wireless sensor network micro-environmental monitoring system. ISA Trans (2008) 2.16
Interface-induced superconductivity and strain-dependent spin density waves in FeSe/SrTiO3 thin films. Nat Mater (2013) 2.15
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination. Immunity (2011) 2.12
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09
Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014. Emerg Infect Dis (2014) 2.08
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc Natl Acad Sci U S A (2008) 2.06
A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiol Biomarkers Prev (2009) 2.04
A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. J Am Coll Cardiol (2005) 2.03
Fat deposition in dilated cardiomyopathy assessed by CMR. JACC Cardiovasc Imaging (2013) 2.00
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res (2009) 1.97
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Presurgical nasoalveolar molding for cleft lip and palate: the application of digitally designed molds. Plast Reconstr Surg (2015) 1.93
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Adaptive optics flood-illumination camera for high speed retinal imaging. Opt Express (2006) 1.92
Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. Proc Natl Acad Sci U S A (2014) 1.91
A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension (2011) 1.90
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab (2010) 1.89
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol (2010) 1.87
Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography. Opt Express (2008) 1.87
Rapid turnover of effector-memory CD4(+) T cells in healthy humans. J Exp Med (2004) 1.85
Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function. J Am Coll Cardiol (2005) 1.85
Cone-beam CT for breast imaging: Radiation dose, breast coverage, and image quality. AJR Am J Roentgenol (2010) 1.83
Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun (2011) 1.82
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem (2004) 1.81
Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation (2011) 1.81
Dynamics of the lakes in the middle and lower reaches of the Yangtze River basin, China, since late nineteenth century. Environ Monit Assess (2012) 1.80
Yeast frataxin solution structure, iron binding, and ferrochelatase interaction. Biochemistry (2004) 1.80
On the Euclidean distance of images. IEEE Trans Pattern Anal Mach Intell (2005) 1.80
Research on an Mg-Zn alloy as a degradable biomaterial. Acta Biomater (2009) 1.80
SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity (2006) 1.79
Quantum dot imaging for embryonic stem cells. BMC Biotechnol (2007) 1.78
Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care (2013) 1.77
Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States. Vet Microbiol (2009) 1.77
A facile and highly atom-economic approach to biaryl-containing medium-ring bislactones. Chem Commun (Camb) (2011) 1.77
Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. Cancer Epidemiol Biomarkers Prev (2005) 1.76
Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A (2011) 1.76
Reduction of B cell turnover in chronic lymphocytic leukaemia. Br J Haematol (2008) 1.74
How human location-specific contact patterns impact spatial transmission between populations? Sci Rep (2013) 1.74
Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. J Natl Cancer Inst (2004) 1.74
Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure. J Am Coll Cardiol (2007) 1.73
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem (2006) 1.70
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene. Proc Natl Acad Sci U S A (2008) 1.69
Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. J Am Chem Soc (2013) 1.69
A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet (2011) 1.68
Emergence and transmission pathways of rapidly evolving evolutionary branch C4a strains of human enterovirus 71 in the Central Plain of China. PLoS One (2011) 1.67
Decompressive hemicraniectomy in malignant middle cerebral artery infarct: a randomized controlled trial enrolling patients up to 80 years old. Neurocrit Care (2012) 1.65
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res (2011) 1.64
Evolution of scaling emergence in large-scale spatial epidemic spreading. PLoS One (2011) 1.64
Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs. Emerg Infect Dis (2014) 1.62
Measurement and modeling of human T cell kinetics. Eur J Immunol (2003) 1.61
NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int (2013) 1.61
Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq. Circ Res (2010) 1.61
The transcription factor DksA prevents conflicts between DNA replication and transcription machinery. Cell (2010) 1.60
Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm. Ann Surg (2009) 1.60
Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. Dig Dis Sci (2009) 1.58
In vivo functional imaging of human cone photoreceptors. Opt Express (2007) 1.58
Cellular FLICE-inhibitory protein protects against cardiac remodeling induced by angiotensin II in mice. Hypertension (2010) 1.57
Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. J Biol Chem (2007) 1.55
Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. Pancreas (2007) 1.54