Functional role of the linker between the complement control protein modules of complement protease C1s.

Disease-causing mutations in genes of the complement system. Am J Hum Genet (2011) 1.24

Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. J Biol Chem (2009) 1.13

Structural basis for activation of the complement system by component C4 cleavage. Proc Natl Acad Sci U S A (2012) 1.08

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J Biol Chem (2003) 2.02

C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol (2004) 1.98

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59

Structure and activation of the C1 complex of complement: unraveling the puzzle. Trends Immunol (2004) 1.59

Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J Immunol Methods (2003) 1.54

Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54

Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J (2007) 1.53

Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29

X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. J Biol Chem (2003) 1.21

Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J Immunol (2005) 1.19

Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. J Biol Chem (2009) 1.16

Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation. Mol Immunol (2009) 1.14

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. EMBO J (2002) 1.13

Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. J Biol Chem (2009) 1.13

Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. J Immunol (2009) 1.11

Molecular organization of human Ficolin-2. Mol Immunol (2006) 1.11

Interaction of C1q and mannan-binding lectin with viruses. Immunobiology (2002) 1.09

Modified low density lipoproteins differentially bind and activate the C1 complex of complement. Mol Immunol (2006) 1.08

Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem (2008) 1.08

Complement protein C1q induces maturation of human dendritic cells. Mol Immunol (2007) 1.06

Evidence that complement protein C1q interacts with C-reactive protein through its globular head region. J Immunol (2006) 1.05

Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. J Biol Chem (2007) 1.04

X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. PLoS One (2011) 1.02

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. J Immunol (2013) 1.01

Studies on the interactions between C-reactive protein and complement proteins. Immunology (2007) 1.01

Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition. J Mol Biol (2011) 1.00

The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J Immunol (2005) 1.00

Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. J Immunol (2007) 0.99

Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism. Structure (2002) 0.98

Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2. J Immunol (2004) 0.98

M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J Immunol (2011) 0.96

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor. Mol Immunol (2007) 0.95

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex. J Biol Chem (2010) 0.94

Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain. J Immunol (2010) 0.94

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites. Proc Natl Acad Sci U S A (2013) 0.94

Deciphering complement mechanisms: the contributions of structural biology. Mol Immunol (2007) 0.93

Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights. Immunobiology (2006) 0.93

The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J Biol Chem (2004) 0.93

Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem (2013) 0.92

Structural insights into the recognition properties of human ficolins. J Innate Immun (2009) 0.92

The human c1q globular domain: structure and recognition of non-immune self ligands. Front Immunol (2012) 0.91

Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity. Mol Immunol (2002) 0.91

Complement protein C1q recognizes a conformationally modified form of the prion protein. Biochemistry (2005) 0.91

Structural and functional characterization of the recombinant human mitochondrial trifunctional protein. Biochemistry (2010) 0.90

Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol (2002) 0.89

Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein. J Biol Chem (2012) 0.88

Mass spectrometry analysis of the oligomeric C1q protein reveals the B chain as the target of trypsin cleavage and interaction with fucoidan. Biochemistry (2005) 0.88

The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition. FEBS Lett (2008) 0.87

Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions. Biochem J (2011) 0.87

Analysis of human C1q by combined bottom-up and top-down mass spectrometry: detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. Mol Cell Proteomics (2009) 0.87