Published in J Biol Chem on September 22, 2005
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci (2009) 3.80
Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia (2009) 1.98
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol Dis (2010) 1.75
mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med (2012) 1.59
The neurology of mTOR. Neuron (2014) 1.43
From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. J Intellect Disabil Res (2009) 1.37
Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learn Mem (2008) 1.35
Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding. Cell Metab (2012) 1.30
The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell (2012) 1.29
Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics (2011) 1.27
Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc Natl Acad Sci U S A (2011) 1.26
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect (2012) 1.25
mTOR signaling and its roles in normal and abnormal brain development. Front Mol Neurosci (2014) 1.19
Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neurosci Lett (2011) 1.12
Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. J Clin Invest (2014) 1.11
Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation. Neuroscience (2010) 1.10
Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol (2011) 1.09
Targeting glial physiology and glutamate cycling in the treatment of depression. Biochem Pharmacol (2009) 1.07
Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. J Neurochem (2008) 1.07
Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cereb Cortex (2008) 1.05
Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease. J Neurochem (2008) 1.02
Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal (2010) 1.00
Elevated synaptic activity preconditions neurons against an in vitro model of ischemia. J Biol Chem (2008) 0.99
Consolidation and translation regulation. Learn Mem (2012) 0.99
Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus. Neuroscience (2011) 0.96
Frontier of epilepsy research - mTOR signaling pathway. Exp Mol Med (2011) 0.95
Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons. Front Cell Neurosci (2014) 0.91
Acute D-serine treatment produces antidepressant-like effects in rodents. Int J Neuropsychopharmacol (2011) 0.90
Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death. J Neurochem (2009) 0.90
A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder. Mol Psychiatry (2015) 0.90
Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons. J Biol Chem (2009) 0.89
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS One (2013) 0.88
Driving neural regeneration through the mammalian target of rapamycin. Neural Regen Res (2014) 0.87
Cutting through the complexities of mTOR for the treatment of stroke. Curr Neurovasc Res (2014) 0.86
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience (2012) 0.84
Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway. Psychopharmacology (Berl) (2012) 0.84
Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization. Neuroscience (2010) 0.83
Taking aim at Alzheimer's disease through the mammalian target of rapamycin. Ann Med (2014) 0.82
Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function. Front Mol Neurosci (2015) 0.82
A critical role for mTORC1 in erythropoiesis and anemia. Elife (2014) 0.82
Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator. Mol Pain (2013) 0.81
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. PLoS One (2013) 0.80
AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures. Epilepsia (2013) 0.80
Activation of NMDA receptor of glutamate influences MMP-2 activity and proliferation of glioma cells. Neurol Sci (2013) 0.80
Novel 5'TOPmRNAs regulated by ribosomal S6 kinase are important for cardiomyocyte development: S6 kinase suppression limits cardiac differentiation and promotes pluripotent cells toward a neural lineage. Stem Cells Dev (2012) 0.78
The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin. Pharmacol Biochem Behav (2009) 0.78
Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity. J Neurosci (2015) 0.77
Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2. J Comp Neurol (2013) 0.77
p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. Biochem J (2007) 0.77
Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors. J Biol Chem (2015) 0.77
Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning. J Neurochem (2015) 0.76
Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION. J Biol Chem (2015) 0.75
Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival. Sci Rep (2017) 0.75
mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine. Sci Rep (2016) 0.75
Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. Learn Mem (2016) 0.75
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell (2002) 11.50
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol (2002) 3.89
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev (2012) 3.62
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem (2001) 3.08
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J (2004) 2.78
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem (2007) 2.77
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol (2002) 2.51
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells (2004) 2.06
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene (2002) 1.96
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One (2012) 1.74
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol (2008) 1.61
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41
Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases. Oncogene (2004) 1.35
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta (2002) 1.32
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene (2002) 1.29
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev (2011) 1.21
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem (2010) 1.20
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol (2008) 1.15
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem (2004) 1.13
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem (2013) 1.04
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem (2011) 0.94
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. J Biol Chem (2007) 0.91
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell (2005) 0.91
Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell (2012) 0.88
mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev (2013) 0.87
Characterization of two Mst1-deficient mouse models. Dev Dyn (2008) 0.85
A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation. Methods Mol Biol (2012) 0.78
pTOM, a vector for expressing two proteins in mammalian cells. Anal Biochem (2009) 0.75