Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

mTOR signaling in growth control and disease. Cell (2012) 29.21

mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08

Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89

ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86

mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 10.07

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol (2009) 9.63

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

mTOR signaling at a glance. J Cell Sci (2009) 8.66

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59

The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91

mTOR regulation of autophagy. FEBS Lett (2010) 6.59

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15

The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol (2004) 5.46

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev (2006) 4.78

Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J (2009) 4.12

Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov (2011) 4.05

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91

Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci (2010) 3.73

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol (2004) 3.72

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol (2006) 3.67

Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest (2007) 3.54

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50

Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal (2010) 3.35

Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol (2009) 3.32

Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics (2011) 3.28

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25

mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol (2009) 3.22

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol (2004) 3.20

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood (2006) 3.13

Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08

The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04

Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96

Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy (2012) 2.87

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86

Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol (2009) 2.86

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84

Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84

mTOR kinase structure, mechanism and regulation. Nature (2013) 2.80

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem (2007) 2.77

mTOR signaling and drug development in cancer. Nat Rev Clin Oncol (2010) 2.77

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A (2009) 2.77

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J (2003) 2.74

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71

mTOR complex 2 signaling and functions. Cell Cycle (2011) 2.66

Regulation of mTORC1 by amino acids. Trends Cell Biol (2014) 2.64

Common corruption of the mTOR signaling network in human tumors. Oncogene (2008) 2.60

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol (2009) 2.57

Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol (2005) 2.47

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol (2005) 2.44

The mTOR signalling pathway in human cancer. Int J Mol Sci (2012) 2.38

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol (2010) 2.33

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol (2007) 2.32

Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol (2004) 2.26

Sirolimus reduces polycystic liver volume in ADPKD patients. J Am Soc Nephrol (2008) 2.26

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab (2011) 2.24

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene (2010) 2.22

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol (2009) 2.15

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One (2007) 2.07

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol (2014) 2.06

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A (2006) 2.06

Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A (2007) 2.06

mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A (2009) 2.05

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol (2003) 2.01

microRNA-101 is a potent inhibitor of autophagy. EMBO J (2011) 2.00

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98

Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals. Plant Cell (2005) 1.98

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem (2009) 1.93

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol (2010) 1.92

The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol (2008) 1.86

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Cancer Res (2006) 1.84

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. Proc Natl Acad Sci U S A (2004) 1.82

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80

Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr (2008) 1.77

The targets of curcumin. Curr Drug Targets (2011) 1.76

S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol (2009) 1.74

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem (2010) 1.74

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem (2008) 1.73

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells. Proc Natl Acad Sci U S A (2003) 1.71

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol (2008) 1.70

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle (2012) 1.67

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem (2009) 1.67

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A (2014) 1.64

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene (2008) 1.64

Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients. Clin Cancer Res (2012) 1.63

mTOR: a pharmacologic target for autophagy regulation. J Clin Invest (2015) 1.61

A comprehensive map of the mTOR signaling network. Mol Syst Biol (2010) 1.59

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci U S A (2010) 1.57

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (2011) 1.56

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39

Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09

Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85

Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol (2002) 3.89

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol (2004) 3.72

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev (2012) 3.62

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem (2001) 3.08

Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03

Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol (2009) 2.86

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J (2004) 2.78

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem (2007) 2.77

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells (2003) 2.62

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol (2002) 2.51

Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci (2004) 2.29

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells (2004) 2.06

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene (2002) 1.96

Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75

Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One (2012) 1.74

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol (2008) 1.61

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61

Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem (2005) 1.59

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem (2010) 1.56

mTOR integrates amino acid- and energy-sensing pathways. Biochem Biophys Res Commun (2004) 1.54

Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42

Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41

Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases. Oncogene (2004) 1.35

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34

Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta (2002) 1.32

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem (2006) 1.31

RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene (2002) 1.29

Recent advances in the regulation of the TOR pathway by insulin and nutrients. Curr Opin Clin Nutr Metab Care (2005) 1.28

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25

Proteome and transcriptome analysis of the virulence genes regulated by the VirR/VirS system in Clostridium perfringens. J Bacteriol (2002) 1.21

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev (2011) 1.21

Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem (2010) 1.20

Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components. Eur J Biochem (2002) 1.19

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans (2009) 1.18

Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol (2008) 1.15

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J Biochem (2006) 1.14

Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. J Biol Chem (2003) 1.14

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem (2004) 1.13

Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells. Biochem Biophys Res Commun (2005) 1.12

Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. J Biol Chem (2005) 1.12

Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem (2003) 1.10

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. EMBO J (2006) 1.10

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase. PLoS One (2008) 1.06

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem (2013) 1.04

Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells. Biochem Biophys Res Commun (2003) 1.02

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01

Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. Biochem Biophys Res Commun (2007) 1.00

Raptor, a binding partner of target of rapamycin. Biochem Biophys Res Commun (2004) 0.98

AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus. J Biol Chem (2007) 0.96

Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins. J Biol Chem (2005) 0.96