Published in J Pharmacol Exp Ther on September 23, 2005
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem (2011) 0.92
Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation. Int J Mol Sci (2011) 0.91
Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain. Brain Res (2006) 0.90
On the interaction of Clostridium perfringens enterotoxin with claudins. Toxins (Basel) (2010) 0.90
Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy. Int J Mol Sci (2013) 0.89
Tight junctions, but not too tight: fine control of lung permeability by claudins. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Specificity of interaction between clostridium perfringens enterotoxin and claudin-family tight junction proteins. Toxins (Basel) (2010) 0.88
Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency. BMC Cancer (2011) 0.84
Systems Proteomics View of the Endogenous Human Claudin Protein Family. J Proteome Res (2016) 0.79
A novel screening system for claudin binder using baculoviral display. PLoS One (2011) 0.77
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Nat Med (2006) 2.27
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol (2002) 2.23
Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib. J Thorac Oncol (2011) 2.07
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology (2003) 1.91
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol (2002) 1.72
Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol (2003) 1.64
Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol Ther (2011) 1.61
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol (2002) 1.61
A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol (2002) 1.59
The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin. Chem Biol (2004) 1.59
Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin. Proc Natl Acad Sci U S A (2007) 1.56
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem (2004) 1.46
Antibody-targeted cell fusion. Nat Biotechnol (2004) 1.39
A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest (2009) 1.36
Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells (2007) 1.35
Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin. EMBO J (2002) 1.33
LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res (2011) 1.32
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J Hepatol (2012) 1.28
Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med (2002) 1.24
Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther (2005) 1.23
Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells. Biol Pharm Bull (2002) 1.22
Silica nanoparticles as hepatotoxicants. Eur J Pharm Biopharm (2009) 1.20
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials (2012) 1.19
Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins. J Biol Chem (2011) 1.18
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Hum Gene Ther (2006) 1.16
Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector. Mol Ther (2003) 1.14
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol Ther (2008) 1.13
Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors. Hum Gene Ther (2007) 1.13
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther (2010) 1.13
Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells (2009) 1.12
Innate immune response induced by gene delivery vectors. Int J Pharm (2007) 1.11
A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol Pharmacol (2004) 1.11
Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports (2013) 1.10
Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production. J Immunol (2007) 1.10
Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J Biol Chem (2010) 1.10
Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem (2008) 1.09
The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications. J Biol Chem (2005) 1.08
Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD'). Oncogene (2005) 1.08
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. Carcinogenesis (2009) 1.08
Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J Immunol (2003) 1.07
RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett (2004) 1.07
Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis (2012) 1.07
Histological analysis of 70-nm silica particles-induced chronic toxicity in mice. Eur J Pharm Biopharm (2009) 1.07
NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. Cancer Res (2012) 1.06
Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem (2004) 1.06
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol (2008) 1.05
Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury. Biol Pharm Bull (2009) 1.05
Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res (2009) 1.04
Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob. J Gene Med (2003) 1.04
Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5. J Gene Med (2009) 1.04
Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation (2003) 1.03
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors. Mol Ther (2005) 1.03
Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure. Nanotechnology (2012) 1.02
Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol (2006) 1.02
Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation. J Virol (2003) 1.01
Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury. Biol Pharm Bull (2010) 1.00
Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex. Nucleic Acids Res (2007) 1.00
Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int J Cancer (2007) 1.00
A novel method for predicting disintegration time in the mouth of rapidly disintegrating tablet by compaction analysis using TabAll. Chem Pharm Bull (Tokyo) (2004) 0.99
Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells. Eur J Biochem (2002) 0.99
Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors. Eur J Immunol (2006) 0.99
RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells. Gene (2005) 0.99
Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction. PLoS One (2011) 0.99
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells. Gastric Cancer (2012) 0.99
Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J Control Release (2007) 0.99
Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers. Int J Cancer (2010) 0.99
Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour. Gut (2011) 0.98
A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol (2009) 0.98
Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease. Differentiation (2007) 0.98
Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription. J Pharmacol Sci (2007) 0.97
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability. J Gene Med (2005) 0.97
Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4. J Control Release (2005) 0.97
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J Immunol (2011) 0.96
Induction of type I interferon by adenovirus-encoded small RNAs. Proc Natl Acad Sci U S A (2010) 0.95
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials (2012) 0.95
Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells. Cell Reprogram (2010) 0.94