Published in Proteins on January 01, 2005
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A (2006) 2.57
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Net charge per residue modulates conformational ensembles of intrinsically disordered proteins. Proc Natl Acad Sci U S A (2010) 2.16
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63
A novel bipartite centrosome coordinates the apicomplexan cell cycle. PLoS Biol (2015) 1.60
Musite, a tool for global prediction of general and kinase-specific phosphorylation sites. Mol Cell Proteomics (2010) 1.55
Sequence composition of disordered regions fine-tunes protein half-life. Nat Struct Mol Biol (2015) 1.55
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
Concern Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances. BMC Genomics (2011) 1.49
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics (2009) 1.41
Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines. Nucleic Acids Res (2006) 1.37
SPINE-D: accurate prediction of short and long disordered regions by a single neural-network based method. J Biomol Struct Dyn (2012) 1.32
Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources. Bioinformatics (2010) 1.30
Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis. PLoS Comput Biol (2009) 1.25
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. Cell Rep (2014) 1.18
The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol (2010) 1.16
Protein tandem repeats - the more perfect, the less structured. FEBS J (2010) 1.15
The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator. Biochemistry (2007) 1.15
PreDisorder: ab initio sequence-based prediction of protein disordered regions. BMC Bioinformatics (2009) 1.15
PEP-19, an intrinsically disordered regulator of calmodulin signaling. J Biol Chem (2008) 1.13
CSpritz: accurate prediction of protein disorder segments with annotation for homology, secondary structure and linear motifs. Nucleic Acids Res (2011) 1.10
Rules governing selective protein carbonylation. PLoS One (2009) 1.10
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
DNdisorder: predicting protein disorder using boosting and deep networks. BMC Bioinformatics (2013) 1.09
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? Mol Cancer (2011) 1.08
Amyloidogenesis of natively unfolded proteins. Curr Alzheimer Res (2008) 1.08
Close packing of Listeria monocytogenes ActA, a natively unfolded protein, enhances F-actin assembly without dimerization. J Biol Chem (2008) 1.07
Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time. Proc Natl Acad Sci U S A (2011) 1.06
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats. Nucleic Acids Res (2007) 1.06
NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond. Angew Chem Int Ed Engl (2010) 1.06
Large-scale prediction of long disordered regions in proteins using random forests. BMC Bioinformatics (2009) 1.05
Analysis of structured and intrinsically disordered regions of transmembrane proteins. Mol Biosyst (2009) 1.05
Library of disordered patterns in 3D protein structures. PLoS Comput Biol (2010) 1.04
CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions. FEBS Lett (2009) 1.03
MeDor: a metaserver for predicting protein disorder. BMC Genomics (2008) 1.03
Correlation between posttranslational modification and intrinsic disorder in protein. Pac Symp Biocomput (2012) 1.02
Intrinsically disordered segments affect protein half-life in the cell and during evolution. Cell Rep (2014) 1.01
Disease mutations in disordered regions--exception to the rule? Mol Biosyst (2011) 1.01
A synthetic resilin is largely unstructured. Biophys J (2008) 1.00
Exploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculations. Biochemistry (2009) 0.99
Protein disorder prediction at multiple levels of sensitivity and specificity. BMC Genomics (2008) 0.99
Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease. J Biol Chem (2011) 0.99
Dynamics and adaptive benefits of protein domain emergence and arrangements during plant genome evolution. Genome Biol Evol (2012) 0.99
Small-molecule inhibitors of the Myc oncoprotein. Biochim Biophys Acta (2014) 0.98
Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be. Bioinformatics (2010) 0.98
Functions of disordered regions in mammalian early base excision repair proteins. Cell Mol Life Sci (2010) 0.98
Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses. Virol J (2009) 0.96
Intrinsically disordered regions of p53 family are highly diversified in evolution. Biochim Biophys Acta (2013) 0.96
The role of structural disorder in the rewiring of protein interactions through evolution. Mol Cell Proteomics (2012) 0.95
Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity. Genome Res (2015) 0.95
PredyFlexy: flexibility and local structure prediction from sequence. Nucleic Acids Res (2012) 0.94
Intrinsically disordered regions in autophagy proteins. Proteins (2013) 0.93
Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins. PLoS One (2007) 0.92
HRaP: database of occurrence of HomoRepeats and patterns in proteomes. Nucleic Acids Res (2013) 0.92
P(3)DB: An Integrated Database for Plant Protein Phosphorylation. Front Plant Sci (2012) 0.91
Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1. Proteins (2009) 0.91
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits. EMBO J (2007) 0.90
Sweeping away protein aggregation with entropic bristles: intrinsically disordered protein fusions enhance soluble expression. Biochemistry (2012) 0.90
Predicting disordered regions in proteins using the profiles of amino acid indices. BMC Bioinformatics (2009) 0.90
A quantitative measure for protein conformational heterogeneity. J Chem Phys (2013) 0.88
P³DB 3.0: From plant phosphorylation sites to protein networks. Nucleic Acids Res (2013) 0.88
Intrinsic disorder and oligomerization of the hepatitis delta virus antigen. Virology (2010) 0.87
Predicting protein flexibility through the prediction of local structures. Proteins (2010) 0.87
Disordered patterns in clustered Protein Data Bank and in eukaryotic and bacterial proteomes. PLoS One (2011) 0.87
Fluctuations of backbone torsion angles obtained from NMR-determined structures and their prediction. Proteins (2010) 0.87
An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro. J Biol Chem (2008) 0.85
Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis. J Proteome Res (2010) 0.85
Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway. Biochemistry (2011) 0.85
Protein structure protection commits gene expression patterns. Genome Biol (2008) 0.85
Intrinsic disorder and protein multibinding in domain, terminal, and linker regions. Mol Biosyst (2010) 0.85
Genome-wide analysis of protein disorder in Arabidopsis thaliana: implications for plant environmental adaptation. PLoS One (2013) 0.85
Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae. J Biol Chem (2011) 0.85
PalmPred: an SVM based palmitoylation prediction method using sequence profile information. PLoS One (2014) 0.84
Predicting and analyzing protein phosphorylation sites in plants using musite. Front Plant Sci (2012) 0.84
Human capacitance to dosage imbalance: coping with inefficient selection. Genome Res (2009) 0.84
Advances in Understanding Carboxysome Assembly in Prochlorococcus and Synechococcus Implicate CsoS2 as a Critical Component. Life (Basel) (2015) 0.84
An experimental and computational evolution-based method to study a mode of co-evolution of overlapping open reading frames in the AAV2 viral genome. PLoS One (2013) 0.84
Structural determinants allowing transferase activity in SENSITIVE TO FREEZING 2, classified as a family I glycosyl hydrolase. J Biol Chem (2014) 0.84
Molecular evolution of dihydrouridine synthases. BMC Bioinformatics (2012) 0.83
Analysis and consensus of currently available intrinsic protein disorder annotation sources in the MobiDB database. BMC Bioinformatics (2013) 0.83
Disorder predictors also predict backbone dynamics for a family of disordered proteins. PLoS One (2011) 0.83
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB. PLoS One (2012) 0.82
The twilight zone between protein order and disorder. Biophys J (2008) 0.82
Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain. BMC Struct Biol (2011) 0.81
Intrinsic disorder in the BK channel and its interactome. PLoS One (2014) 0.81
Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment. PLoS One (2010) 0.81
RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45. J Biol Chem (2014) 0.81
Sequence TTKF ↓ QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae. J Biol Chem (2011) 0.81
Predictors of natively unfolded proteins: unanimous consensus score to detect a twilight zone between order and disorder in generic datasets. BMC Bioinformatics (2010) 0.81
A comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks. Front Physiol (2014) 0.81
FlgM proteins from different bacteria exhibit different structural characteristics. Biochim Biophys Acta (2013) 0.80
The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23
Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol (2002) 5.64
A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61
DisProt: the Database of Disordered Proteins. Nucleic Acids Res (2006) 4.46
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Automated inference of molecular mechanisms of disease from amino acid substitutions. Bioinformatics (2009) 4.31
Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys (2008) 3.98
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling. J Mol Recognit (2005) 3.57
Analysis of molecular recognition features (MoRFs). J Mol Biol (2006) 3.40
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments. Bioinformatics (2006) 3.00
Coupled folding and binding with alpha-helix-forming molecular recognition elements. Biochemistry (2005) 2.94
Predicting intrinsic disorder from amino acid sequence. Proteins (2003) 2.74
Flavors of protein disorder. Proteins (2003) 2.72
Testing the ortholog conjecture with comparative functional genomic data from mammals. PLoS Comput Biol (2011) 2.63
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A (2006) 2.57
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
A computational approach toward label-free protein quantification using predicted peptide detectability. Bioinformatics (2006) 2.48
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Evolutionary rate heterogeneity in proteins with long disordered regions. J Mol Evol (2002) 2.46
Comparing and combining predictors of mostly disordered proteins. Biochemistry (2005) 2.45
Protein flexibility and intrinsic disorder. Protein Sci (2004) 2.33
Predicting intrinsic disorder in proteins: an overview. Cell Res (2009) 2.24
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Optimizing long intrinsic disorder predictors with protein evolutionary information. J Bioinform Comput Biol (2005) 2.20
DisProt: a database of protein disorder. Bioinformatics (2004) 1.99
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92
Disorder and sequence repeats in hub proteins and their implications for network evolution. J Proteome Res (2006) 1.87
In silico functional profiling of human disease-associated and polymorphic amino acid substitutions. Hum Mutat (2010) 1.81
An integrated approach to inferring gene-disease associations in humans. Proteins (2008) 1.80
Intrinsically disordered proteins and intrinsically disordered protein regions. Annu Rev Biochem (2014) 1.79
D²P²: database of disordered protein predictions. Nucleic Acids Res (2012) 1.75
Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J Biol Chem (2007) 1.74
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70
Composition Profiler: a tool for discovery and visualization of amino acid composition differences. BMC Bioinformatics (2007) 1.64
Calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions. Hum Mutat (2012) 1.61
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. Curr Opin Struct Biol (2013) 1.61
Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57
Close encounters of the third kind: disordered domains and the interactions of proteins. Bioessays (2009) 1.56
Musite, a tool for global prediction of general and kinase-specific phosphorylation sites. Mol Cell Proteomics (2010) 1.55
Natively disordered proteins: functions and predictions. Appl Bioinformatics (2004) 1.55
Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition. Proteins (2006) 1.51
Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol (2004) 1.51
Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life. J Biomol Struct Dyn (2012) 1.51
Evolution and disorder. Curr Opin Struct Biol (2011) 1.50
Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization. J Biol Chem (2004) 1.49
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins. Bioinformatics (2012) 1.49
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome. Protein Pept Lett (2009) 1.45
Addressing the intrinsic disorder bottleneck in structural proteomics. Proteins (2005) 1.44
Overlapping genes produce proteins with unusual sequence properties and offer insight into de novo protein creation. J Virol (2009) 1.42
Conservation of intrinsic disorder in protein domains and families: I. A database of conserved predicted disordered regions. J Proteome Res (2006) 1.42
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics (2009) 1.41
Polymerization of calsequestrin. Implications for Ca2+ regulation. J Biol Chem (2003) 1.39
Evaluation of features for catalytic residue prediction in novel folds. Protein Sci (2006) 1.39
Intrinsic disorder in the Protein Data Bank. J Biomol Struct Dyn (2007) 1.37
Signal transduction via unstructured protein conduits. Nat Chem Biol (2008) 1.36
Analysis of protein function and its prediction from amino acid sequence. Proteins (2011) 1.36
Malleable machines in transcription regulation: the mediator complex. PLoS Comput Biol (2008) 1.35
Improved amino acid flexibility parameters. Protein Sci (2003) 1.34
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing. Genome Biol (2014) 1.32
SPINE-D: accurate prediction of short and long disordered regions by a single neural-network based method. J Biomol Struct Dyn (2012) 1.32
Conservation of intrinsic disorder in protein domains and families: II. functions of conserved disorder. J Proteome Res (2006) 1.27
Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity. Am J Hum Genet (2011) 1.26
A bayesian approach to protein inference problem in shotgun proteomics. J Comput Biol (2009) 1.26
Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding. Protein Sci (2013) 1.23
Abundance of intrinsic disorder in protein associated with cardiovascular disease. Biochemistry (2006) 1.19
Uncovering protein interaction in abstracts and text using a novel linear model and word proximity networks. Genome Biol (2008) 1.19
Classification and knowledge discovery in protein databases. J Biomed Inform (2004) 1.18
Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs. J Proteome Res (2006) 1.17
A computational investigation of allostery in the catabolite activator protein. J Am Chem Soc (2007) 1.17
Prediction of boundaries between intrinsically ordered and disordered protein regions. Pac Symp Biocomput (2003) 1.16