Published in Biochemistry on February 15, 2005
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Biophysical characterization of intrinsically disordered proteins. Curr Opin Struct Biol (2009) 1.98
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein Sci (2013) 1.74
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63
Chaperone activity of ERD10 and ERD14, two disordered stress-related plant proteins. Plant Physiol (2008) 1.54
Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry (2008) 1.50
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics (2009) 1.41
Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res (2006) 1.39
Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines. Nucleic Acids Res (2006) 1.37
The K-segment of maize DHN1 mediates binding to anionic phospholipid vesicles and concomitant structural changes. Plant Physiol (2009) 1.34
Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein. Proc Natl Acad Sci U S A (2013) 1.34
Protein aggregation processes: In search of the mechanism. Protein Sci (2007) 1.32
Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources. Bioinformatics (2010) 1.30
Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins. Genome Biol (2009) 1.21
Natively unstructured loops differ from other loops. PLoS Comput Biol (2007) 1.19
The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol (2010) 1.16
PreDisorder: ab initio sequence-based prediction of protein disordered regions. BMC Bioinformatics (2009) 1.15
Predicting mostly disordered proteins by using structure-unknown protein data. BMC Bioinformatics (2007) 1.12
Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation. Endocr Rev (2012) 1.11
Protein disorder in the human diseasome: unfoldomics of human genetic diseases. BMC Genomics (2009) 1.11
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? Mol Cancer (2011) 1.08
Amyloidogenesis of natively unfolded proteins. Curr Alzheimer Res (2008) 1.08
Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol (2009) 1.08
Nanoimaging for protein misfolding and related diseases. J Cell Biochem (2006) 1.05
Analysis of structured and intrinsically disordered regions of transmembrane proteins. Mol Biosyst (2009) 1.05
Archaic chaos: intrinsically disordered proteins in Archaea. BMC Syst Biol (2010) 1.05
PROTEUS2: a web server for comprehensive protein structure prediction and structure-based annotation. Nucleic Acids Res (2008) 1.04
Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation. J Mol Evol (2007) 1.04
MeDor: a metaserver for predicting protein disorder. BMC Genomics (2008) 1.03
CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions. FEBS Lett (2009) 1.03
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03
Time window expansion for HDX analysis of an intrinsically disordered protein. J Am Soc Mass Spectrom (2013) 1.02
Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome. J Proteome Res (2009) 1.02
The importance of being flexible: the case of basic region leucine zipper transcriptional regulators. Curr Protein Pept Sci (2009) 1.01
Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins. Protein Sci (2010) 1.01
Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope. J Biol Chem (2012) 1.00
Computational prediction of O-linked glycosylation sites that preferentially map on intrinsically disordered regions of extracellular proteins. Int J Mol Sci (2010) 0.99
Independent structural domains in paramyxovirus polymerase protein. J Biol Chem (2012) 0.98
Dynamic interactions between clathrin and locally structured elements in a disordered protein mediate clathrin lattice assembly. J Mol Biol (2010) 0.98
Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be. Bioinformatics (2010) 0.98
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98
Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors. J Leukoc Biol (2014) 0.97
Multifarious roles of intrinsic disorder in proteins illustrate its broad impact on plant biology. Plant Cell (2013) 0.96
Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses. Virol J (2009) 0.96
Intrinsically disordered regions of p53 family are highly diversified in evolution. Biochim Biophys Acta (2013) 0.96
Filming biomolecular processes by high-speed atomic force microscopy. Chem Rev (2014) 0.95
N-terminal domains of DELLA proteins are intrinsically unstructured in the absence of interaction with GID1/gibberellic acid receptors. J Biol Chem (2010) 0.95
Electrostatically accelerated encounter and folding for facile recognition of intrinsically disordered proteins. PLoS Comput Biol (2013) 0.95
Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance. Proc Natl Acad Sci U S A (2010) 0.94
Organism complexity anti-correlates with proteomic beta-aggregation propensity. Protein Sci (2005) 0.94
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices. Protein Sci (2011) 0.93
The C-terminal domain of the transcriptional corepressor CtBP is intrinsically unstructured. Protein Sci (2006) 0.92
A comparative analysis of viral matrix proteins using disorder predictors. Virol J (2008) 0.91
Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1. Proteins (2009) 0.91
Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission. PLoS Curr (2013) 0.91
Resilience of death: intrinsic disorder in proteins involved in the programmed cell death. Cell Death Differ (2013) 0.90
DExD/H-box Prp5 protein is in the spliceosome during most of the splicing cycle. RNA (2009) 0.89
Disordered flanks prevent peptide aggregation. PLoS Comput Biol (2008) 0.89
At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation. J Mol Biol (2009) 0.88
Nonnative interactions in coupled folding and binding processes of intrinsically disordered proteins. PLoS One (2010) 0.87
In-silico prediction of disorder content using hybrid sequence representation. BMC Bioinformatics (2011) 0.87
Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol (2013) 0.86
Flexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches. J R Soc Interface (2011) 0.86
Protein disorder is positively correlated with gene expression in Escherichia coli. J Proteome Res (2008) 0.86
An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro. J Biol Chem (2008) 0.85
Retro-MoRFs: identifying protein binding sites by normal and reverse alignment and intrinsic disorder prediction. Int J Mol Sci (2010) 0.85
Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites. Protein Sci (2013) 0.85
Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response. PLoS One (2011) 0.85
Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether. Protein Sci (2011) 0.84
Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome. PeerJ (2013) 0.84
Correlations between predicted protein disorder and post-translational modifications in plants. Bioinformatics (2014) 0.84
Induced secondary structure and polymorphism in an intrinsically disordered structural linker of the CNS: solid-state NMR and FTIR spectroscopy of myelin basic protein bound to actin. Biophys J (2009) 0.84
Anchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein. Int J Mol Sci (2011) 0.84
Disorder predictors also predict backbone dynamics for a family of disordered proteins. PLoS One (2011) 0.83
DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. Biomed Res Int (2014) 0.82
Flexible peptides and cytoplasmic gels. Genome Biol (2005) 0.82
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
High-throughput characterization of intrinsic disorder in proteins from the Protein Structure Initiative. J Struct Biol (2012) 0.82
The twilight zone between protein order and disorder. Biophys J (2008) 0.82
DRM1 and DRM2 expression regulation: potential role of splice variants in response to stress and environmental factors in Arabidopsis. Mol Genet Genomics (2014) 0.81
Mutual synergistic protein folding in split intein. Biosci Rep (2012) 0.81
Inherent relationships among different biophysical prediction methods for intrinsically disordered proteins. Biophys J (2013) 0.81
Predictors of natively unfolded proteins: unanimous consensus score to detect a twilight zone between order and disorder in generic datasets. BMC Bioinformatics (2010) 0.81
The hydrophobic temperature dependence of amino acids directly calculated from protein structures. PLoS Comput Biol (2015) 0.80
FlgM proteins from different bacteria exhibit different structural characteristics. Biochim Biophys Acta (2013) 0.80
Differential occurrence of protein intrinsic disorder in the cytoplasmic signaling domains of cell receptors. Self Nonself (2011) 0.80
The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem (2013) 0.79
Thermal unfolding of the N-terminal region of p53 monitored by circular dichroism spectroscopy. Protein Sci (2012) 0.79
On the intrinsic disorder status of the major players in programmed cell death pathways. F1000Res (2013) 0.79
Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J Mol Biol (2008) 0.79
Intrinsic disorder and protein function. Biochemistry (2002) 8.54
The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23
Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol (2002) 5.64
Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36
DisProt: the Database of Disordered Proteins. Nucleic Acids Res (2006) 4.46
Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. ISME J (2007) 4.36
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Function and structure of inherently disordered proteins. Curr Opin Struct Biol (2008) 4.19
Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys (2008) 3.98
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling. J Mol Recognit (2005) 3.57
Analysis of molecular recognition features (MoRFs). J Mol Biol (2006) 3.40
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Exploiting heterogeneous sequence properties improves prediction of protein disorder. Proteins (2005) 3.14
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Coupled folding and binding with alpha-helix-forming molecular recognition elements. Biochemistry (2005) 2.94
Predicting intrinsic disorder from amino acid sequence. Proteins (2003) 2.74
Flavors of protein disorder. Proteins (2003) 2.72
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A (2006) 2.57
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Evolutionary rate heterogeneity in proteins with long disordered regions. J Mol Evol (2002) 2.46
Protein flexibility and intrinsic disorder. Protein Sci (2004) 2.33
Assessing protein disorder and induced folding. Proteins (2006) 2.33
Predicting intrinsic disorder in proteins: an overview. Cell Res (2009) 2.24
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Identification and functions of usefully disordered proteins. Adv Protein Chem (2002) 2.23
Optimizing long intrinsic disorder predictors with protein evolutionary information. J Bioinform Comput Biol (2005) 2.20
A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins. Mol Cell Proteomics (2010) 2.09
Molecular microbial ecology: land of the one-eyed king. Curr Opin Microbiol (2004) 2.06
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem (2001) 1.99
DisProt: a database of protein disorder. Bioinformatics (2004) 1.99
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils. Chem Biol (2004) 1.91
Disorder and sequence repeats in hub proteins and their implications for network evolution. J Proteome Res (2006) 1.87
Intrinsically disordered proteins and intrinsically disordered protein regions. Annu Rev Biochem (2014) 1.79
Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol (2008) 1.76
D²P²: database of disordered protein predictions. Nucleic Acids Res (2012) 1.75
Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J Biol Chem (2007) 1.74
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry (2002) 1.71
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
Introducing protein intrinsic disorder. Chem Rev (2014) 1.66
Composition Profiler: a tool for discovery and visualization of amino acid composition differences. BMC Bioinformatics (2007) 1.64
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. Curr Opin Struct Biol (2013) 1.61
Do viral proteins possess unique biophysical features? Trends Biochem Sci (2008) 1.60
The vaginal bacterial communities of Japanese women resemble those of women in other racial groups. FEMS Immunol Med Microbiol (2009) 1.59
Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57
Common features at the start of the neurodegeneration cascade. PLoS Biol (2012) 1.56
Close encounters of the third kind: disordered domains and the interactions of proteins. Bioessays (2009) 1.56
Musite, a tool for global prediction of general and kinase-specific phosphorylation sites. Mol Cell Proteomics (2010) 1.55
Natively disordered proteins: functions and predictions. Appl Bioinformatics (2004) 1.55
Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition. Proteins (2006) 1.51
Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes. Biochemistry (2003) 1.51
Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol (2004) 1.51
Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life. J Biomol Struct Dyn (2012) 1.51