Published in J Biol Chem on September 28, 2005
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol (2008) 4.47
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Selective autophagy: ubiquitin-mediated recognition and beyond. Nat Cell Biol (2010) 3.74
Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol (2010) 3.54
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A (2011) 3.20
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci (2009) 2.95
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis (2010) 2.69
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein. J Neurosci (2011) 2.53
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol (2006) 2.17
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene (2009) 2.13
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors. Cancer Res (2010) 2.11
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A (2010) 2.09
Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci (2013) 2.05
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet (2008) 2.05
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation (2008) 1.95
Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia. Neuromuscul Disord (2009) 1.94
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol (2009) 1.92
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma. Autophagy (2014) 1.84
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. J Biol Chem (2008) 1.82
The role of HDAC6 in cancer. J Biomed Biotechnol (2010) 1.77
Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell (2012) 1.77
Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy. Hum Mol Genet (2010) 1.75
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta (2008) 1.73
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
What causes cell death in Parkinson's disease? Ann Neurol (2008) 1.66
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet (2008) 1.63
Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol (2008) 1.61
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Hum Mol Genet (2008) 1.58
Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb Perspect Biol (2010) 1.52
Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy (2007) 1.50
Role of microtubules in extracellular release of poliovirus. J Virol (2009) 1.49
Protein aggregates in Huntington's disease. Exp Neurol (2011) 1.46
Autophagy protects against de novo formation of the [PSI+] prion in yeast. Mol Biol Cell (2015) 1.45
The tale of protein lysine acetylation in the cytoplasm. J Biomed Biotechnol (2010) 1.44
Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. J Neurosci (2011) 1.44
The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol (2011) 1.43
Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38
Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem (2008) 1.38
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet (2008) 1.36
The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res (2009) 1.36
Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem (2009) 1.34
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clin Cancer Res (2008) 1.33
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J Biol Chem (2010) 1.29
Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool. J Biol Chem (2010) 1.28
Autophagy: regulation and role in development. Autophagy (2013) 1.28
The UBL domain of PLIC-1 regulates aggresome formation. EMBO Rep (2006) 1.27
Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system. J Biol Chem (2009) 1.26
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy (2009) 1.25
Acetylated microtubules are required for fusion of autophagosomes with lysosomes. BMC Cell Biol (2010) 1.24
Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem (2010) 1.20
Why should autophagic flux be assessed? Acta Pharmacol Sin (2013) 1.16
Relationship between the proteasomal system and autophagy. Int J Biochem Mol Biol (2013) 1.16
The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes Cancer (2010) 1.15
HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacol Res (2010) 1.15
Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. PLoS One (2010) 1.14
Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease. J Neurosci (2011) 1.14
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med (2008) 1.14
Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin Cancer Res (2009) 1.14
The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones. Neurobiol Dis (2006) 1.13
The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration. Neurobiol Dis (2010) 1.12
Pathophysiology of protein aggregation and extended phenotyping in filaminopathy. Brain (2012) 1.12
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Mol Neurodegener (2013) 1.12
Huntington's Disease. Cold Spring Harb Perspect Biol (2011) 1.11
Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell (2013) 1.10
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. PLoS One (2012) 1.08
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Hum Mol Genet (2010) 1.08
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS One (2011) 1.07
Disruption of protein quality control in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.07
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Res (2007) 1.07
Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol (2012) 1.07
Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy (2008) 1.06
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species. J Cell Sci (2014) 1.06
Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol (2005) 5.84
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol (2008) 4.54
Global changes to the ubiquitin system in Huntington's disease. Nature (2007) 3.91
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol (2009) 3.55
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell (2005) 3.28
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc Natl Acad Sci U S A (2005) 2.69
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol (2011) 2.28
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system. J Biol Chem (2002) 2.26
Cytoplasmic dynein/dynactin mediates the assembly of aggresomes. Cell Motil Cytoskeleton (2002) 2.11
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum. Nat Struct Mol Biol (2011) 1.64
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools. Nat Methods (2011) 1.60
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J (2007) 1.56
The mammalian endoplasmic reticulum-associated degradation system. Cold Spring Harb Perspect Biol (2013) 1.50
A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator. J Biol Chem (2002) 1.48
Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Proc Natl Acad Sci U S A (2008) 1.41
Application and analysis of the GFPu family of ubiquitin-proteasome system reporters. Methods Enzymol (2005) 1.28
Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens. Anal Biochem (2006) 1.27
A role for mammalian Ubc6 homologues in ER-associated protein degradation. J Cell Sci (2002) 1.26
Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis. J Clin Invest (2002) 1.20
Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa. J Biol Chem (2004) 1.20
Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Proc Natl Acad Sci U S A (2013) 1.20
Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants. EMBO J (2007) 1.18
Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease. J Cell Biol (2012) 1.18
The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem (2009) 1.10
The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol (2007) 1.10
Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell (2012) 1.03
ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding. Dev Cell (2012) 1.01
Recognition of a single transmembrane degron by sequential quality control checkpoints. Mol Biol Cell (2003) 1.00
Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells. Proc Natl Acad Sci U S A (2005) 1.00
Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation. J Biol Chem (2011) 0.93
Immunoglobulin light chains dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway. J Biol Chem (2003) 0.92
Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease. J Biol Chem (2013) 0.91
Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II. FEBS Lett (2002) 0.90
Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface. J Biol Chem (2012) 0.89
Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels. Biophys J (2002) 0.89
SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells. Biochim Biophys Acta (2009) 0.89
Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease. PLoS One (2013) 0.88
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics. PLoS One (2013) 0.87
Autophagy inhibition engages Nrf2-p62 Ub-associated signaling. Autophagy (2011) 0.83
Cystic fibrosis: premature degradation of mutant proteins as a molecular disease mechanism. Methods Mol Biol (2003) 0.82
Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb. Mol Reprod Dev (2011) 0.82
Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice. PLoS One (2012) 0.81
Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD. Nat Struct Mol Biol (2012) 0.80
The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease. J Cell Mol Med (2009) 0.80
Live-cell imaging of ubiquitin-proteasome system function. Methods Mol Biol (2012) 0.78
Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains. Nat Cell Biol (2016) 0.75
The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters. J Gen Physiol (2003) 0.75
Cellular mechanisms of protein quality control. Rinsho Shinkeigaku (2006) 0.75