Published in J Biol Chem on October 05, 2005
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest (2009) 4.29
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab (2011) 2.94
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab (2008) 2.47
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am J Pathol (2008) 2.15
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell (2006) 1.93
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Cardiac Na+ current regulation by pyridine nucleotides. Circ Res (2009) 1.87
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J Biol Chem (2009) 1.86
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev (2007) 1.86
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Parthanatos, a messenger of death. Front Biosci (Landmark Ed) (2009) 1.84
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One (2011) 1.81
Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. J Mol Cell Cardiol (2007) 1.81
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res (2009) 1.74
Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des (2009) 1.69
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med (2013) 1.62
From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60
PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab (2011) 1.55
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol (2006) 1.49
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis. J Pharmacol Exp Ther (2009) 1.48
SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes (2009) 1.44
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD. PLoS One (2015) 1.44
Sirtuins at a glance. J Cell Sci (2011) 1.41
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res (2010) 1.40
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res (2010) 1.38
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. J Biol Chem (2012) 1.36
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta (2009) 1.29
SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res (2009) 1.29
Metabolic stress, reactive oxygen species, and arrhythmia. J Mol Cell Cardiol (2011) 1.26
SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2013) 1.25
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One (2012) 1.23
Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction. Br J Pharmacol (2009) 1.22
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun (2015) 1.21
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. Stroke (2008) 1.18
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12
Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) (2009) 1.09
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol (2015) 1.06
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. J Mol Cell Cardiol (2011) 1.03
The role of redox signaling in epigenetics and cardiovascular disease. Antioxid Redox Signal (2013) 1.03
Nicotinamide Phosphoribosyltransferase in Human Diseases. J Bioanal Biomed (2011) 1.01
Resveratrol in cardiovascular disease: what is known from current research? Heart Fail Rev (2012) 1.01
Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on Sirtuins. Int J Mol Sci (2013) 1.00
Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem (2010) 1.00
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging (Albany NY) (2011) 0.99
Downregulation of Sirt1 as aging change in advanced heart failure. J Biomed Sci (2014) 0.99
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart. Circ Res (2014) 0.98
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res (2010) 0.98
SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97
Cardiac sodium channel mutations: why so many phenotypes? Nat Rev Cardiol (2014) 0.96
Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. Br J Pharmacol (2013) 0.96
Regulation of cell survival and death by pyridine nucleotides. Circ Res (2012) 0.95
Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS One (2012) 0.95
Genetics and epigenetics of arrhythmia and heart failure. Front Genet (2013) 0.94
Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase. J Biol Chem (2012) 0.93
Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. PLoS One (2014) 0.93
Adrenergic signaling and oxidative stress: a role for sirtuins? Front Physiol (2013) 0.93
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. Mutat Res (2010) 0.92
Metabolic mechanisms of epigenetic regulation. ACS Chem Biol (2013) 0.92
From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. Biochim Biophys Acta (2009) 0.92
FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J Biol Chem (2011) 0.90
The importance of NAD in multiple sclerosis. Curr Pharm Des (2009) 0.89
The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol (2015) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. Am J Respir Cell Mol Biol (2014) 0.88
Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner. Cell Death Differ (2015) 0.88
Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One (2014) 0.88
Differential expression of sirtuins in the aging rat brain. Front Cell Neurosci (2015) 0.87
Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes. Eur J Pharmacol (2012) 0.86
The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxid Med Cell Longev (2015) 0.86
Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice. PLoS One (2014) 0.86
Regulation of SIRT1 by microRNAs. Mol Cells (2013) 0.86
Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds. Nat Rev Mol Cell Biol (2016) 0.86
Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC. J Mol Cell Cardiol (2011) 0.83
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metab (2016) 0.83
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
Differential expression of sirtuin family members in the developing, adult, and aged rat brain. Front Aging Neurosci (2014) 0.82
Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. PLoS One (2011) 0.82
Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion. Mol Med (2015) 0.81
Antioxidative and cardioprotective properties of anthocyanins from defatted dabai extracts. Evid Based Complement Alternat Med (2013) 0.81
Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism. Aging (Albany NY) (2014) 0.81
Secretion of one adipokine Nampt/Visfatin suppresses the inflammatory stress-induced NF-κB activity and affects Nampt-dependent cell viability in Huh-7 cells. Mediators Inflamm (2015) 0.80
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem (2004) 5.37
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest (2009) 4.29
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab (2011) 3.38
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res (2004) 2.82
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol (2006) 2.03
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J Biol Chem (2009) 1.86
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal (2011) 1.69
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med (2012) 1.69
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol (2007) 1.66
The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab (2012) 1.55
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci (2010) 1.51
Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem (2008) 1.29
Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. Cardiovasc Res (2013) 1.21
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol (2006) 1.20
TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters. Biochem Biophys Res Commun (2002) 1.16
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol (2013) 1.15
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. J Muscle Res Cell Motil (2012) 1.14
A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. J Biol Chem (2012) 1.12
Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. J Mol Cell Cardiol (2011) 1.03
Retracted HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity. J Biol Chem (2010) 1.03
Retracted A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem (2013) 1.00
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. Am J Physiol Heart Circ Physiol (2004) 0.99
Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts. Am J Physiol Heart Circ Physiol (2002) 0.99
Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. Am J Physiol Heart Circ Physiol (2004) 0.95
Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J Clin Endocrinol Metab (2014) 0.95
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. Am J Physiol Heart Circ Physiol (2012) 0.94
Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. Am J Physiol Heart Circ Physiol (2008) 0.94
Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4. Mol Cell Biol (2007) 0.93
A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. Aging Cell (2011) 0.91
Endothelial cell preservation at 10 degrees C minimizes catalytic iron, oxidative stress, and cold-induced injury. Cell Transplant (2006) 0.87
Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy. Cell Biochem Biophys (2005) 0.86
The single-strand DNA/RNA-binding protein, Purbeta, regulates serum response factor (SRF)-mediated cardiac muscle gene expression. Can J Physiol Pharmacol (2007) 0.86
Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo. Mech Ageing Dev (2008) 0.84
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Mol Cell Biol (2011) 0.82
Hypothalamic Sirt1 in aging. Aging (Albany NY) (2014) 0.80
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci (2014) 0.79
Proteomic analysis of endothelial cold-adaptation. BMC Genomics (2011) 0.77
Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome. Mol Cell (2011) 0.77
Hypothermic preconditioning of endothelial cells attenuates cold-induced injury by a ferritin-dependent process. Free Radic Biol Med (2008) 0.76
Nuclear import of serum response factor in airway smooth muscle. Am J Respir Cell Mol Biol (2010) 0.75
Endothelial cell fatty acid unsaturation mediates cold-induced oxidative stress. J Cell Biochem (2006) 0.75
Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism. J Biol Chem (2017) 0.75
A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem (2017) 0.75