Published in Mol Cells on November 06, 2013
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Mol Cell Biol (2014) 1.09
Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells. Mol Cells (2014) 0.85
Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Nat Commun (2016) 0.82
Sirtuin 1 signaling and alcoholic fatty liver disease. Hepatobiliary Surg Nutr (2015) 0.81
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis. Aging (Albany NY) (2016) 0.78
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Isocaloric Pair-Fed High-Carbohydrate Diet Induced More Hepatic Steatosis and Inflammation than High-Fat Diet Mediated by miR-34a/SIRT1 Axis in Mice. Sci Rep (2015) 0.76
Reversible modulation of SIRT1 activity in a mouse strain. PLoS One (2017) 0.75
Peroxisome Proliferator-Activated Receptor α Facilitates Osteogenic Differentiation in MC3T3-E1 Cells via the Sirtuin 1-Dependent Signaling Pathway. Mol Cells (2017) 0.75
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab (2006) 12.41
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell (2009) 11.10
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
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Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
MiR-33 contributes to the regulation of cholesterol homeostasis. Science (2010) 6.93
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science (2010) 5.77
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Gene regulation by transcription factors and microRNAs. Science (2008) 5.07
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A (2007) 4.87
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
MicroRNA-34a regulates cardiac ageing and function. Nature (2013) 4.03
MicroRNAs 103 and 107 regulate insulin sensitivity. Nature (2011) 3.98
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology (2008) 3.68
NAD+ metabolism in health and disease. Trends Biochem Sci (2006) 3.45
Sirtuins as potential targets for metabolic syndrome. Nature (2006) 3.38
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab (2011) 3.38
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A (2011) 3.35
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature (2012) 2.94
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab (2011) 2.94
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol (2003) 2.77
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J Biol Chem (2005) 2.73
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res (2008) 2.51
Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One (2011) 2.48
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
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Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One (2010) 2.44
microRNA-34c is a novel target to treat dementias. EMBO J (2011) 2.44
Sirtuin functions in health and disease. Mol Endocrinol (2007) 2.38
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A (2010) 2.27
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab (2009) 2.27
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem (2010) 2.20
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem (2007) 2.15
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS One (2010) 1.89
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes (2008) 1.85
Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol Cancer Ther (2011) 1.76
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem (2010) 1.61
MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun (2010) 1.58
Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol (2011) 1.50
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology (2013) 1.49
Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun (2006) 1.49
Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res (2009) 1.43
MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol (2009) 1.41
Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice. Aging (Albany NY) (2011) 1.32
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1. Mech Ageing Dev (2011) 1.31
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho. Proc Natl Acad Sci U S A (2012) 1.26
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia (2012) 1.23
MicroRNAs in metabolism and metabolic diseases. Cold Spring Harb Symp Quant Biol (2011) 1.21
Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell (2013) 1.19
Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. FEBS J (2011) 1.18
Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY) (2010) 1.12
SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.12
Small RNA regulators of gene expression. Cell (2008) 1.10
The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem (2013) 1.09
Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. PLoS One (2013) 0.95
Mitochondrial sirtuins and metabolic homeostasis. Best Pract Res Clin Endocrinol Metab (2012) 0.92
In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. Metabolism (2011) 0.89
Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism. Vitam Horm (2013) 0.88
Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev (2006) 2.36
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem (2010) 2.20
Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol (2006) 1.72
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev (2009) 1.62
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem (2010) 1.61
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. J Biol Chem (2004) 1.46
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem (2008) 1.27
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho. Proc Natl Acad Sci U S A (2012) 1.26
Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Mol Endocrinol (2002) 1.25
Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY) (2010) 1.12
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology (2012) 1.09
Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. Mol Cell Biol (2009) 1.06
Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes. J Biol Chem (2013) 1.06
Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol (2007) 1.04
Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. J Biol Chem (2002) 1.00
Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). DNA Cell Biol (2004) 0.99
Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. Mol Cell Biol (2011) 0.97
Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol (2012) 0.94
Cross-regulation of protein stability by p53 and nuclear receptor SHP. PLoS One (2012) 0.86
Epigenomic regulation of bile acid metabolism: emerging role of transcriptional cofactors. Mol Cell Endocrinol (2012) 0.86
Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Mol Endocrinol (2011) 0.81
Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Arch Biochem Biophys (2006) 0.77