Activation of the Src family kinase Hck without SH3-linker release.

Multidomain assembled states of Hck tyrosine kinase in solution. Proc Natl Acad Sci U S A (2010) 1.79

On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases. Proc Natl Acad Sci U S A (2007) 1.21

An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Sci (2005) 1.17

Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner. J Biol Chem (2010) 1.08

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Sci (2007) 1.01

Structure and dynamic regulation of Abl kinases. J Biol Chem (2013) 1.01

Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains. Biophys J (2006) 0.97

Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism. J Biol Chem (2010) 0.93

Active site profiling reveals coupling between domains in SRC-family kinases. Nat Chem Biol (2012) 0.91

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene (2008) 0.88

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. Int Rev Phys Chem (2013) 0.87

Cooperative activation of Src family kinases by SH3 and SH2 ligands. Cancer Lett (2007) 0.86

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. PLoS One (2014) 0.85

Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src. PLoS One (2013) 0.82

Retracted HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells. J Biol Chem (2008) 0.82

Computational study of the W260A activating mutant of Src tyrosine kinase. Protein Sci (2015) 0.78

A selective NMR probe to monitor the conformational transition from inactive to active kinase. ACS Chem Biol (2014) 0.78

Structural dynamic analysis of apo and ATP-bound IRAK4 kinase. Sci Rep (2014) 0.78

SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family. Biochemistry (2014) 0.77

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor. Biochemistry (2015) 0.77

The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor. J Am Soc Mass Spectrom (2014) 0.76

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region. Chem Biol Drug Des (2014) 0.76

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. Cell Commun Signal (2017) 0.75

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature (2009) 7.05

Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrom Rev (2005) 5.23

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39

Semi-automated data processing of hydrogen exchange mass spectra using HX-Express. J Am Soc Mass Spectrom (2006) 2.92

High-speed and high-resolution UPLC separation at zero degrees Celsius. Anal Chem (2008) 2.27

Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. J Am Soc Mass Spectrom (2006) 2.25

Inhibition of histone deacetylase expands the renal progenitor cell population. J Am Soc Nephrol (2010) 1.94

The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J Pharm Sci (2010) 1.90

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res (2004) 1.88

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem (2003) 1.88

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol (2009) 1.88

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat Rev Drug Discov (2012) 1.80

Conformational locking upon cooperative assembly of notch transcription complexes. Structure (2012) 1.79

SRC family kinase activity is required for murine embryonic stem cell growth and differentiation. Mol Pharmacol (2005) 1.77

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A (2006) 1.68

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64

Post-translational modifications differentially affect IgG1 conformation and receptor binding. Mol Cell Proteomics (2010) 1.59

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J (2002) 1.55

HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J Biol Chem (2006) 1.51

Conformational disturbance in Abl kinase upon mutation and deregulation. Proc Natl Acad Sci U S A (2009) 1.47

Hydrogen exchange mass spectrometry: what is it and what can it tell us? Anal Bioanal Chem (2010) 1.46

Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem (2002) 1.37

Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry. Anal Chem (2010) 1.36

SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo. Nat Struct Biol (2002) 1.36

Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol Cell Biol (2011) 1.35

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl (2013) 1.34

Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res (2003) 1.30

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29

Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem (2006) 1.27

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene (2002) 1.24

Hydrogen exchange mass spectrometry: are we out of the quicksand? J Am Soc Mass Spectrom (2012) 1.23

Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem (2009) 1.22

Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrom (2006) 1.21

HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication. J Mol Biol (2009) 1.19

Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry. Anal Chem (2006) 1.18

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol (2009) 1.18

Partial unfolding of diverse SH3 domains on a wide timescale. J Mol Biol (2006) 1.17

An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Sci (2005) 1.17

Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16

Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck. Biochemistry (2004) 1.14

Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Curr Protoc Protein Sci (2009) 1.13

DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res (2010) 1.12

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. J Mol Biol (2007) 1.12

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A (2009) 1.12

Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One (2011) 1.12

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell (2010) 1.10

Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner. J Biol Chem (2010) 1.08

Differential function of STAT5 isoforms in head and neck cancer growth control. Oncogene (2002) 1.07

Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07

Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations. Anal Chem (2009) 1.07

Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. J Mol Biol (2005) 1.07

False EX1 signatures caused by sample carryover during HX MS analyses. Int J Mass Spectrom (2011) 1.06

Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra. J Am Soc Mass Spectrom (2013) 1.06

The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol (2012) 1.05

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol (2013) 1.05

Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review). Int J Mol Med (2007) 1.04

N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. J Biol Chem (2009) 1.04

Effects of HIV-1 Nef on human N-myristoyltransferase 1. Biochemistry (2011) 1.01

ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements. J Am Soc Mass Spectrom (2011) 1.01

Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase. J Mol Biol (2004) 1.01

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Sci (2007) 1.01

Structure and dynamic regulation of Abl kinases. J Biol Chem (2013) 1.01

HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner. J Biol Chem (2004) 0.98

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. Mol Cell Biol (2004) 0.98

A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. Biochemistry (2014) 0.97

A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter. J Med Chem (2013) 0.96

Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution. Biochemistry (2011) 0.96

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry. Anal Chem (2009) 0.95

Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. J Mol Biol (2008) 0.95

Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry (2008) 0.95

Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange. Rapid Commun Mass Spectrom (2008) 0.94

Arsenic inhibition of the JAK-STAT pathway. Oncogene (2004) 0.94

The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology (2002) 0.94

Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry (2006) 0.93

Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Sci Signal (2009) 0.93

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. PLoS One (2012) 0.93

Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism. J Biol Chem (2010) 0.93

Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci (2013) 0.92

Fetal alcohol exposure alters neurosteroid levels in the developing rat brain. J Neurochem (2004) 0.91

On the solution conformation and dynamics of the HIV-1 viral infectivity factor. J Mol Biol (2011) 0.91

Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. Biochemistry (2003) 0.91

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. J Biol Chem (2013) 0.90