Published in J Am Soc Mass Spectrom on July 27, 2006
HD desktop: an integrated platform for the analysis and visualization of H/D exchange data. J Am Soc Mass Spectrom (2008) 1.82
HDX workbench: software for the analysis of H/D exchange MS data. J Am Soc Mass Spectrom (2012) 1.80
The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data. BMC Bioinformatics (2007) 1.72
Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics. Structure (2014) 1.49
Hydrogen exchange mass spectrometry: what is it and what can it tell us? Anal Bioanal Chem (2010) 1.46
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Expert Rev Proteomics (2011) 1.45
ExMS: data analysis for HX-MS experiments. J Am Soc Mass Spectrom (2011) 1.44
Hydra: software for tailored processing of H/D exchange data from MS or tandem MS analyses. BMC Bioinformatics (2009) 1.38
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29
Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom (2010) 1.28
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem (2009) 1.22
Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120. J Virol (2012) 1.21
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env. Nat Commun (2015) 1.14
Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Curr Protoc Protein Sci (2009) 1.13
Solution structural dynamics of HIV-1 reverse transcriptase heterodimer. Biochemistry (2009) 1.08
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07
Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra. J Am Soc Mass Spectrom (2013) 1.06
Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nat Struct Mol Biol (2015) 1.03
Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97. Mol Cell Proteomics (2010) 1.01
The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Sci (2007) 1.01
Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution. Biochemistry (2011) 0.96
Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. J Mol Biol (2008) 0.95
Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry (2008) 0.95
HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta(2)-microglobulin upon release from the MHC-1. J Am Soc Mass Spectrom (2008) 0.94
HK97 maturation studied by crystallography and H/2H exchange reveals the structural basis for exothermic particle transitions. J Mol Biol (2010) 0.94
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome. Science (2016) 0.94
Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annu Rev Anal Chem (Palo Alto Calif) (2015) 0.92
On the solution conformation and dynamics of the HIV-1 viral infectivity factor. J Mol Biol (2011) 0.91
Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. J Biol Chem (2013) 0.90
H/D exchange centroid monitoring is insufficient to show differences in the behavior of protein states. J Am Soc Mass Spectrom (2013) 0.89
Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via multifaceted structural approaches. J Biol Chem (2013) 0.89
The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. Rapid Commun Mass Spectrom (2012) 0.88
Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry. Protein Sci (2010) 0.88
Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. Int Rev Phys Chem (2013) 0.87
Hexicon 2: automated processing of hydrogen-deuterium exchange mass spectrometry data with improved deuteration distribution estimation. J Am Soc Mass Spectrom (2014) 0.86
Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods Mol Biol (2013) 0.85
PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. PLoS Biol (2013) 0.85
Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. J Mol Biol (2010) 0.84
Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling. Biophys J (2015) 0.84
Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry. 2. Exchange kinetics. Mol Pharm (2012) 0.83
Scope and utility of hydrogen exchange as a tool for mapping landscapes. Protein Sci (2007) 0.83
Continuous and Pulsed Hydrogen-Deuterium Exchange and Mass Spectrometry Characterize CsgE Oligomerization. Biochemistry (2015) 0.83
Comparison of Two ESI MS Based H/D Exchange Methods for Extracting Protein Folding Energies. Int J Mass Spectrom (2009) 0.82
RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry. Phys Chem Chem Phys (2010) 0.82
Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip. Protein Sci (2006) 0.82
Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. J Mol Biol (2006) 0.82
Changes in solvent accessibility of wild-type and deamidated βB2-crystallin following complex formation with αA-crystallin. Exp Eye Res (2012) 0.81
Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS). Mol Pharm (2014) 0.81
Effective application of bicelles for conformational analysis of G protein-coupled receptors by hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrom (2015) 0.81
Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger. Sci Rep (2016) 0.81
Subunit Interactions within the Carbon-Phosphorus Lyase Complex from Escherichia coli. Biochemistry (2015) 0.80
Efavirenz binding site in HIV-1 reverse transcriptase monomers. Biochemistry (2010) 0.79
DnaC traps DnaB as an open ring and remodels the domain that binds primase. Nucleic Acids Res (2015) 0.79
Dynamics of the Tec-family tyrosine kinase SH3 domains. Protein Sci (2016) 0.78
Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry. Anal Chem (2014) 0.78
Analyzing protein dynamics using hydrogen exchange mass spectrometry. J Vis Exp (2013) 0.77
Detection of early unfolding events in a dimeric protein by amide proton exchange and native electrospray mass spectrometry. Protein Sci (2009) 0.77
Theory of the Protein Equilibrium Population Snapshot by H/D Exchange Electrospray Ionization Mass Spectrometry (PEPS-HDX-ESI-MS) Method used to obtain Protein Folding Energies/Rates and Selected Supporting Experimental Evidence. Int J Mass Spectrom (2012) 0.76
Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. J Am Soc Mass Spectrom (2016) 0.76
Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry. Protein Sci (2015) 0.75
Bacterial flagellar capping proteins adopt diverse oligomeric states. Elife (2016) 0.75
Protein Structural Analysis via Mass Spectrometry-Based Proteomics. Adv Exp Med Biol (2016) 0.75
Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods. J Pharm Sci (2016) 0.75
Isotope Labeling of Biomolecules: Structural Analysis of Viruses by HDX-MS. Methods Enzymol (2015) 0.75
Conformational changes in intact dengue virus reveal serotype-specific expansion. Nat Commun (2017) 0.75
Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion. Viruses (2016) 0.75
Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics. Int J Mass Spectrom (2012) 0.75
Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS. Proc Natl Acad Sci U S A (2017) 0.75
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature (2009) 7.05
Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrom Rev (2005) 5.23
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express. J Am Soc Mass Spectrom (2006) 2.92
A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51
The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A (2004) 2.32
High-speed and high-resolution UPLC separation at zero degrees Celsius. Anal Chem (2008) 2.27
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J Pharm Sci (2010) 1.90
Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat Rev Drug Discov (2012) 1.80
Conformational locking upon cooperative assembly of notch transcription complexes. Structure (2012) 1.79
Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments. Protein Sci (2006) 1.75
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol (2003) 1.68
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67
Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64
Post-translational modifications differentially affect IgG1 conformation and receptor binding. Mol Cell Proteomics (2010) 1.59
Conformational disturbance in Abl kinase upon mutation and deregulation. Proc Natl Acad Sci U S A (2009) 1.47
Hydrogen exchange mass spectrometry: what is it and what can it tell us? Anal Bioanal Chem (2010) 1.46
Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry. Anal Chem (2010) 1.36
Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl (2013) 1.34
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol (2004) 1.32
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol (2008) 1.29
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem (2006) 1.27
Hydrogen exchange mass spectrometry: are we out of the quicksand? J Am Soc Mass Spectrom (2012) 1.23
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem (2009) 1.22
Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrom (2006) 1.21
Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry. Anal Chem (2006) 1.18
Partial unfolding of diverse SH3 domains on a wide timescale. J Mol Biol (2006) 1.17
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Sci (2005) 1.17
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
Activation of the Src family kinase Hck without SH3-linker release. J Biol Chem (2005) 1.14
Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Curr Protoc Protein Sci (2009) 1.13
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A (2003) 1.12
Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. J Mol Biol (2007) 1.12
Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One (2011) 1.12
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci (2005) 1.11
Comparative surface geometry of the protein kinase family. Protein Sci (2009) 1.08
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07
Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations. Anal Chem (2009) 1.07
Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. J Mol Biol (2005) 1.07
False EX1 signatures caused by sample carryover during HX MS analyses. Int J Mass Spectrom (2011) 1.06
Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra. J Am Soc Mass Spectrom (2013) 1.06
The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol (2012) 1.05
Effects of HIV-1 Nef on human N-myristoyltransferase 1. Biochemistry (2011) 1.01
ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements. J Am Soc Mass Spectrom (2011) 1.01
The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Sci (2007) 1.01
Structure and dynamic regulation of Abl kinases. J Biol Chem (2013) 1.01
A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. Biochemistry (2014) 0.97
Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution. Biochemistry (2011) 0.96
Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry. Anal Chem (2009) 0.95
Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. J Mol Biol (2008) 0.95
Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry (2008) 0.95
Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange. Rapid Commun Mass Spectrom (2008) 0.94
Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry (2006) 0.93
Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annu Rev Anal Chem (Palo Alto Calif) (2015) 0.92
Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci (2013) 0.92
Fetal alcohol exposure alters neurosteroid levels in the developing rat brain. J Neurochem (2004) 0.91
On the solution conformation and dynamics of the HIV-1 viral infectivity factor. J Mol Biol (2011) 0.91
Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. Biochemistry (2003) 0.91
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res (2012) 0.90
Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. J Biol Chem (2013) 0.90
Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. Protein Sci (2002) 0.89
Protein interactions probed with mass spectrometry. Methods Mol Biol (2006) 0.89
R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol (2007) 0.88
Accessing the reproducibility and specificity of pepsin and other aspartic proteases. Biochim Biophys Acta (2012) 0.88
Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. Int Rev Phys Chem (2013) 0.87
Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation. J Am Soc Mass Spectrom (2012) 0.87
Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements. J Pharm Sci (2013) 0.87
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. BMC Chem Biol (2012) 0.86
Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif. J Mol Biol (2010) 0.86
Progress in computation and amide hydrogen exchange for prediction of protein-protein complexes. Proteins (2005) 0.86
L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase. J Am Chem Soc (2005) 0.86
Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry. Chem Res Toxicol (2002) 0.86
Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. Proc Natl Acad Sci U S A (2006) 0.86
Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi. Anal Chem (2012) 0.86
Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties. Anal Chem (2013) 0.85
Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods Mol Biol (2013) 0.85
Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry (2013) 0.84
Conformational transition of membrane-associated terminally acylated HIV-1 Nef. Structure (2013) 0.84
Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins (2003) 0.84
Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. J Mol Biol (2010) 0.84
Protein structural alignment for detection of maximally conserved regions. Biophys Chem (2003) 0.84
Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes. Biophys J (2010) 0.83
Computational reconstruction of multidomain proteins using atomic force microscopy data. Structure (2012) 0.82
Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip. Protein Sci (2006) 0.82
Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. J Mol Biol (2006) 0.82
Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Sci Signal (2013) 0.82
Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii. FEBS J (2007) 0.82