Published in FEBS Lett on September 28, 2005
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A (2007) 4.92
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis (2007) 2.82
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A (2006) 2.49
Mcl-1 is required for melanoma cell resistance to anoikis. Mol Cancer Res (2009) 2.36
Apoptosis and oncogenesis: give and take in the BCL-2 family. Curr Opin Genet Dev (2011) 1.71
Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Mol Biol Cell (2007) 1.65
Delving deeper: MCL-1's contributions to normal and cancer biology. Trends Cell Biol (2012) 1.60
A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J (2014) 1.55
Ubiquitin-independent degradation of antiapoptotic MCL-1. Mol Cell Biol (2010) 1.54
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J (2010) 1.49
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J Biol Chem (2011) 1.31
Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo. PLoS One (2012) 1.27
BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes. Oncogene (2008) 1.23
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A (2010) 1.23
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. ACS Chem Biol (2009) 1.16
Ubiquitin-proteasome system as a modulator of cell fate. Curr Opin Pharmacol (2007) 1.09
Mcl-1 ubiquitination: unique regulation of an essential survival protein. Cells (2014) 1.09
Programming cancer cells for high expression levels of Mcl1. EMBO Rep (2013) 1.06
Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem (2010) 1.02
Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia (2012) 1.00
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2. Biochemistry (2012) 0.96
Regulation of Bim in Health and Disease. Oncotarget (2015) 0.95
Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis. J Virol (2007) 0.93
Parkin mitochondria in the autophagosome. J Cell Biol (2008) 0.92
Replication licensing and the DNA damage checkpoint. Front Biosci (Landmark Ed) (2009) 0.90
ARF-BP1 as a potential therapeutic target. Br J Cancer (2006) 0.86
Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J (2012) 0.83
Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors. BMC Cancer (2011) 0.83
Association of anti-apoptotic Mcl-1L isoform expression with radioresistance of oral squamous carcinoma cells. Radiat Oncol (2012) 0.83
Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells. Br J Cancer (2011) 0.79
A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration. Oncotarget (2013) 0.79
Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget (2016) 0.77
The double life of MULE in preeclamptic and IUGR placentae. Cell Death Dis (2012) 0.77
A conformational switch regulates the ubiquitin ligase HUWE1. Elife (2017) 0.75
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature (2008) 38.13
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst (2009) 10.91
Identification and characterization of multi-species conserved sequences. Genome Res (2003) 10.18
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell (2012) 6.09
Spreading the word. Nature (2007) 5.03
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A (2007) 4.92
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat Genet (2009) 4.72
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature (2010) 4.64
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. PLoS Biol (2005) 4.48
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood (2008) 3.89
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood (2007) 3.73
Reconstructing contiguous regions of an ancestral genome. Genome Res (2006) 3.68
PhyME: a probabilistic algorithm for finding motifs in sets of orthologous sequences. BMC Bioinformatics (2004) 3.63
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol (2003) 3.54
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med (2006) 3.37
Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene (2003) 3.32
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA (2003) 2.74
Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncol (2010) 2.74
Phylo: a citizen science approach for improving multiple sequence alignment. PLoS One (2012) 2.64
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J (2005) 2.63
A probabilistic approach for SNP discovery in high-throughput human resequencing data. Genome Res (2009) 2.55
Into the heart of darkness: large-scale clustering of human non-coding DNA. Bioinformatics (2004) 2.50
PReMod: a database of genome-wide mammalian cis-regulatory module predictions. Nucleic Acids Res (2006) 2.27
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24
Unique biology of Mcl-1: therapeutic opportunities in cancer. Curr Mol Med (2008) 2.22
Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A (2004) 2.21
The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters. FASEB J (2012) 2.13
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J (2009) 2.08
Asking questions changes behavior: mere measurement effects on frequency of blood donation. Health Psychol (2008) 2.04
The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts. Genome Biol (2014) 2.01
Neurocognitive profile in 22q11 deletion syndrome and schizophrenia. Schizophr Res (2006) 1.89
BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization. J Biol Chem (2003) 1.83
Three-dimensional modeling of chromatin structure from interaction frequency data using Markov chain Monte Carlo sampling. BMC Bioinformatics (2011) 1.78
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nat Cell Biol (2011) 1.76
The Capsella rubella genome and the genomic consequences of rapid mating system evolution. Nat Genet (2013) 1.69
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A (2003) 1.69
An atlas of over 90,000 conserved noncoding sequences provides insight into crucifer regulatory regions. Nat Genet (2013) 1.68
Chromatin conformation signatures of cellular differentiation. Genome Biol (2009) 1.68
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64
Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast Cancer Res Treat (2010) 1.60
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol (2009) 1.60
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J (2006) 1.59
BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J Biol Chem (2005) 1.58
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle (2012) 1.56
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood (2007) 1.55
BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. J Biol Chem (2002) 1.52
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell (2008) 1.51
Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol Cell Biol (2005) 1.49
Factors affecting red blood cell storage age at the time of transfusion. Transfusion (2013) 1.47
Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53. Oncogene (2002) 1.47
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.45
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol (2008) 1.44
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet (2013) 1.37
Cellular distribution of Bcl-2 family proteins. Sci STKE (2003) 1.36
The three-dimensional architecture of Hox cluster silencing. Nucleic Acids Res (2010) 1.36
Bcl-2 and calcium: controversy beneath the surface. Oncogene (2004) 1.36
Exact and heuristic algorithms for the Indel Maximum Likelihood Problem. J Comput Biol (2007) 1.35
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J Biol Chem (2011) 1.31
Safety and immunogenicity of a trivalent, inactivated, mammalian cell culture-derived influenza vaccine in healthy adults, seniors, and children. Vaccine (2002) 1.29
Reactive oxygen species: stuck in the middle of neurodegeneration. J Alzheimers Dis (2010) 1.28
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. Methods (2009) 1.24
Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). Plant Cell (2010) 1.24
The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. Mol Cell Proteomics (2010) 1.23
Bap29/31 influences the intracellular traffic of MHC class I molecules. J Immunol (2004) 1.22
Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim Biophys Acta (2006) 1.20
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. J Biol Chem (2003) 1.19
Which survey questions change behavior? Randomized controlled trial of mere measurement interventions. Health Psychol (2010) 1.19
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states. Am J Physiol Endocrinol Metab (2004) 1.19
Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst) (2003) 1.18
S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway. Mol Cell Biol (2004) 1.16
On the inference of parsimonious indel evolutionary scenarios. J Bioinform Comput Biol (2006) 1.14
Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle. Hum Mol Genet (2012) 1.14
Determinants of repeated blood donation among new and experienced blood donors. Transfusion (2007) 1.13
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat (2012) 1.12
Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. J Biol Chem (2003) 1.12
Seeder: discriminative seeding DNA motif discovery. Bioinformatics (2008) 1.10
Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer. Clin Cancer Res (2012) 1.09
Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis. Dev Dyn (2007) 1.07
Declining value of preoperative autologous donation. Transfusion (2002) 1.07
Programming cancer cells for high expression levels of Mcl1. EMBO Rep (2013) 1.06
Open-Phylo: a customizable crowd-computing platform for multiple sequence alignment. Genome Biol (2013) 1.06
Optimizing the use of open-source software applications in drug discovery. Drug Discov Today (2006) 1.04
Modeling contaminants in AP-MS/MS experiments. J Proteome Res (2010) 1.03
A flexible ancestral genome reconstruction method based on gapped adjacencies. BMC Bioinformatics (2012) 1.03
Ancestors 1.0: a web server for ancestral sequence reconstruction. Bioinformatics (2009) 1.01
WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol (2007) 1.00
BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival. J Biol Chem (2005) 0.99