Published in Blood on September 28, 2006
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A (2011) 1.71
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med (2012) 1.24
CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease. ISRN Hematol (2013) 1.16
CD47: a new target in cardiovascular therapy. Arterioscler Thromb Vasc Biol (2008) 1.05
Mouse models with human immunity and their application in biomedical research. J Cell Mol Med (2008) 0.99
Xenotransplantation: immunological hurdles and progress toward tolerance. Immunol Rev (2014) 0.97
CD47 is required for suppression of allograft rejection by donor-specific transfusion. J Immunol (2010) 0.96
Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood (2012) 0.91
Analysis of innate defences against Plasmodium falciparum in immunodeficient mice. Malar J (2010) 0.87
"Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. J Biol Chem (2015) 0.86
Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol (2012) 0.85
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol (2008) 0.84
T-cell-mediated immunological barriers to xenotransplantation. Xenotransplantation (2012) 0.84
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism. Immunol Rev (2008) 0.83
CD47 in xenograft rejection and tolerance induction. Xenotransplantation (2010) 0.83
Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation. Am J Transplant (2014) 0.82
Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells. Cell Mol Immunol (2012) 0.82
Role of CD47 and Signal Regulatory Protein Alpha (SIRPα) in Regulating the Clearance of Viable or Aged Blood Cells. Transfus Med Hemother (2012) 0.82
Immune responses following mouse peripheral nerve xenotransplantation in rats. J Biomed Biotechnol (2009) 0.81
Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPα capable of binding to human CD47. Cell Transplant (2011) 0.81
High incidence of xenogenic bone marrow engraftment in pig-to-baboon intra-bone bone marrow transplantation. Am J Transplant (2015) 0.80
Lack of CD47 on donor hepatocytes promotes innate immune cell activation and graft loss: a potential barrier to hepatocyte xenotransplantation. Cell Transplant (2013) 0.80
CD47: a new player in phagocytosis and xenograft rejection. Cell Mol Immunol (2011) 0.80
Current progress in xenogeneic tolerance. Curr Opin Organ Transplant (2012) 0.79
Survival and function of CD47-deficient thymic grafts in mice. Xenotransplantation (2010) 0.79
Innate cellular immunity and xenotransplantation. Curr Opin Organ Transplant (2012) 0.77
Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc Natl Acad Sci U S A (2016) 0.76
High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism. Xenotransplantation (2009) 0.75
Rapid dendritic cell activation and resistance to allotolerance induction in anti-CD154-treated mice receiving CD47-deficient donor-specific transfusion. Cell Transplant (2013) 0.75
Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice. PLoS One (2013) 0.75
Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47. Transplantation (2016) 0.75
Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants. Am J Transplant (2016) 0.75
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease. Front Immunol (2017) 0.75
Role of CD47 as a marker of self on red blood cells. Science (2000) 7.00
Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science (2000) 4.41
By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell (2003) 3.65
A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26
CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J Exp Med (2001) 2.75
Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity (2000) 2.64
Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem (1999) 2.44
A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med (1997) 2.05
CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med (2001) 1.99
Mixed chimerism and transplant tolerance. Immunity (2001) 1.97
Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol (2005) 1.86
Will the pig solve the transplantation backlog? Annu Rev Med (2002) 1.74
Siglecs, sialic acids and innate immunity. Trends Immunol (2001) 1.73
CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol (2000) 1.46
Exacerbated graft-versus-host disease in Pirb-/- mice. Nat Immunol (2004) 1.42
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood (2004) 1.19
Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood (2002) 1.14
The pig as a xenograft donor. Pathol Biol (Paris) (1994) 1.14
Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells. Xenotransplantation (2005) 1.08
Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation (2000) 1.08
Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol (2002) 1.02
Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons. Transplantation (2001) 1.00
T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection. Transplantation (1996) 0.95
Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood (2002) 0.94
Fetal porcine islet-like cell clusters transplanted to cynomolgus monkeys: an immunohistochemical study. Transplantation (1999) 0.93
Molecular cloning and functional characterization of the pig homologue of integrin-associated protein (IAP/CD47). Immunology (2002) 0.93
Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation (1998) 0.93
Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection. J Immunol (2001) 0.92
Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice. Transplantation (1996) 0.91
Novel CD47-dependent intercellular adhesion modulates cell migration. J Cell Physiol (2005) 0.90
Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation (2005) 0.89
Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes. Leukemia (1997) 0.87
Cloning and transgenesis in mammals: implications for xenotransplantation. Am J Transplant (2004) 0.86
CD8-interaction mutant HLA-Cw3 molecules protect porcine cells from human natural killer cell-mediated antibody-dependent cellular cytotoxicity without stimulating cytotoxic T lymphocytes. Transplantation (2003) 0.78
Application of xenogeneic stem cells for induction of transplantation tolerance: present state and future directions. Springer Semin Immunopathol (2004) 0.78
The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model. Xenotransplantation (1999) 0.78
HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med (2008) 7.42
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell (2005) 5.90
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity (2012) 3.21
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood (2006) 2.94
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Prion switching in response to environmental stress. PLoS Biol (2008) 2.61
Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without a proinflammatory cytokine response. Transfusion (2012) 2.60
Clinical trial of islet xenotransplantation in Mexico. Xenotransplantation (2006) 2.51
CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant (2004) 2.45
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature (2011) 2.44
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett (2009) 2.17
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem (2005) 2.10
The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PLoS One (2012) 2.05
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med (2006) 1.94
Tolerance induction in clinical transplantation. Transpl Immunol (2004) 1.90
Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol (2004) 1.87
Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol (2005) 1.86
High expression of CD73 as a poor prognostic biomarker in human colorectal cancer. J Surg Oncol (2012) 1.81
Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol (2007) 1.80
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Extraperitoneal vs. intraperitoneal route for permanent colostomy: a meta-analysis of 1,071 patients. Int J Colorectal Dis (2011) 1.77
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation (2002) 1.75
Stapled side-to-side anastomosis might be better than handsewn end-to-end anastomosis in ileocolic resection for Crohn's disease: a meta-analysis. Dig Dis Sci (2014) 1.67
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. Blood (2003) 1.64
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther (2009) 1.55
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood (2005) 1.55
Association of metformin use with cancer incidence and mortality: a meta-analysis. Cancer Epidemiol (2013) 1.49
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood (2002) 1.49
Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation (2003) 1.47
Delivery of RNA interference. Cell Cycle (2006) 1.43
The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood (2007) 1.37
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation (2003) 1.36
No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes (2004) 1.35
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant (2003) 1.35
Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J Immunol (2003) 1.34
HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med (2013) 1.29
Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol (2002) 1.28
A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med (2012) 1.27
Mixed chimerism, lymphocyte recovery, and evidence for early donor-specific unresponsiveness in patients receiving combined kidney and bone marrow transplantation to induce tolerance. Transplantation (2010) 1.25
Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood (2002) 1.24
The spatial and temporal dynamics of rabies in China. PLoS Negl Trop Dis (2012) 1.23
Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex. Blood (2002) 1.22
Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol (2005) 1.22
Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. Semin Immunol (2011) 1.21
Emerging concepts in haematopoietic cell transplantation. Nat Rev Immunol (2012) 1.20
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. Blood (2008) 1.19
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood (2004) 1.19
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol (2010) 1.18
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet (2013) 1.17
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. J Clin Invest (2003) 1.16
Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction. Biochem Biophys Res Commun (2006) 1.15
Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood (2007) 1.14
Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells (2002) 1.14
Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant (2004) 1.14
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant (2006) 1.13
Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism. Transplantation (2003) 1.12
An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant (2007) 1.12
Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol (2011) 1.12
Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation (2011) 1.12
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test. J Neurosci (2010) 1.10
Chronic diseases knowledge and related factors among the elderly in Jinan, China. PLoS One (2013) 1.10
Mapping gene activity of Arabidopsis root hairs. Genome Biol (2013) 1.10
CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol (2009) 1.09
Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol (2005) 1.08
EU-OSTID: a collection of transposon insertional mutants for functional genomics in rice. Plant Mol Biol (2005) 1.08
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem (2011) 1.08
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. Exp Hematol (2007) 1.07
Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal. Stem Cell Res (2011) 1.07
Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion. Am J Pathol (2011) 1.06