Dying cell clearance and its impact on the outcome of tumor radiotherapy.

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Published in Front Oncol on September 11, 2012

Authors

Kirsten Lauber1, Anne Ernst, Michael Orth, Martin Herrmann, Claus Belka

Author Affiliations

1: Department of Radiotherapy and Radiation Oncology, Ludwig Maximilian University of Munich Munich, Germany.

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p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest (1998) 13.05

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol (1992) 11.24

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol (2008) 8.30

Interferons, immunity and cancer immunoediting. Nat Rev Immunol (2006) 8.23

The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58

Immunosuppressive effects of apoptotic cells. Nature (1997) 7.03

Identification of a factor that links apoptotic cells to phagocytes. Nature (2002) 6.76

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature (2001) 6.31

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature (2011) 6.14

Identification of Tim4 as a phosphatidylserine receptor. Nature (2007) 6.06

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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell (2005) 5.90

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