Published in J Biol Chem on November 03, 2005
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes Dev (2009) 5.04
Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol (2009) 4.07
tRNA biology charges to the front. Genes Dev (2010) 4.07
tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA (2008) 3.39
Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell (2011) 3.23
Uncovering small RNA-mediated responses to phosphate deficiency in Arabidopsis by deep sequencing. Plant Physiol (2009) 2.98
The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol (2009) 2.61
RNA granules: the good, the bad and the ugly. Cell Signal (2010) 2.31
Meta-analysis of small RNA-sequencing errors reveals ubiquitous post-transcriptional RNA modifications. Nucleic Acids Res (2009) 2.27
Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis. Nucleic Acids Res (2008) 2.10
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor. Nucleic Acids Res (2007) 1.84
The phloem-delivered RNA pool contains small noncoding RNAs and interferes with translation. Plant Physiol (2009) 1.76
Slicing tRNAs to boost functional ncRNA diversity. RNA Biol (2013) 1.68
Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res (2012) 1.66
RNA repair: an antidote to cytotoxic eukaryal RNA damage. Mol Cell (2008) 1.64
Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia. Nucleic Acids Res (2008) 1.52
Regulatory RNAs derived from transfer RNA? RNA (2010) 1.50
Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem (2012) 1.47
Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells. RNA Biol (2013) 1.43
Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection. Mol Ther (2012) 1.41
Emerging role of angiogenin in stress response and cell survival under adverse conditions. J Cell Physiol (2012) 1.38
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. EMBO J (2014) 1.31
A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo. Genes Dev (2010) 1.30
Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae. Genetics (2013) 1.20
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism. RNA (2010) 1.20
Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol (2014) 1.18
Cellular dynamics of tRNAs and their genes. FEBS Lett (2010) 1.17
Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana. BMC Genomics (2009) 1.11
Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes (Basel) (2012) 1.10
Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells. Parasitol Res (2013) 1.10
Transfer RNA as a source of small functional RNA. J Mol Biol Mol Imaging (2015) 1.08
Archaeal and eukaryotic homologs of Hfq: A structural and evolutionary perspective on Sm function. RNA Biol (2013) 1.07
Angiogenin-mediated rRNA transcription in cancer and neurodegeneration. Int J Biochem Mol Biol (2010) 1.06
The short non-coding transcriptome of the protozoan parasite Trypanosoma cruzi. PLoS Negl Trop Dis (2011) 1.01
Structured non-coding RNAs and the RNP Renaissance. Curr Opin Chem Biol (2008) 1.01
Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies. Oncotarget (2015) 1.00
Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC. Nucleic Acids Res (2010) 0.95
Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments. Mol Cancer Res (2015) 0.93
Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism. Mol Ther (2015) 0.91
Identification of stable, high copy number, medium-sized RNA degradation intermediates that accumulate in plants under non-stress conditions. Plant Mol Biol (2013) 0.91
Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs. RNA (2011) 0.87
RNA degradome--its biogenesis and functions. Nucleic Acids Res (2011) 0.87
5' tRNA Halves: The Next Generation of Immune Signaling Molecules. Front Immunol (2015) 0.86
Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena. Mol Biol Cell (2011) 0.86
tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression. Life (Basel) (2015) 0.86
Surveillance and cleavage of eukaryotic tRNAs. Int J Mol Sci (2015) 0.85
tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae. RNA (2012) 0.85
Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants. Nucleic Acids Res (2011) 0.85
The role of cis-zeatin-type cytokinins in plant growth regulation and mediating responses to environmental interactions. J Exp Bot (2015) 0.84
piRNAs from Pig Testis Provide Evidence for a Conserved Role of the Piwi Pathway in Post-Transcriptional Gene Regulation in Mammals. PLoS One (2015) 0.84
Genome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila. BMC Genomics (2009) 0.84
RNA Granules Living a Post-transcriptional Life: the Trypanosomes' Case. Curr Chem Biol (2011) 0.82
Precise mapping and dynamics of tRNA-derived fragments (tRFs) in the development of Triops cancriformis (tadpole shrimp). BMC Genet (2015) 0.81
2D-PAGE as an effective method of RNA degradome analysis. Mol Biol Rep (2011) 0.80
Regulation of cell death by transfer RNA. Antioxid Redox Signal (2013) 0.80
Structure-function analysis of Rny1 in tRNA cleavage and growth inhibition. PLoS One (2012) 0.80
Fragmentation of tRNA in Phytophthora infestans asexual life cycle stages and during host plant infection. BMC Microbiol (2014) 0.79
Characterization of Small RNAs Derived from tRNAs, rRNAs and snoRNAs and Their Response to Heat Stress in Wheat Seedlings. PLoS One (2016) 0.79
Beyond the Ribosome: Extra-translational Functions of tRNA Fragments. Biomark Insights (2016) 0.78
tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers. Nucleic Acids Res (2016) 0.77
Regulation of translation dynamic and neoplastic conversion by tRNA and their pieces. Translation (Austin) (2014) 0.75
Conserved and highly expressed tRNA derived fragments in zebrafish. BMC Mol Biol (2015) 0.75
Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei. Sci Rep (2017) 0.75
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol (2011) 2.43
Telomere maintenance and disease. Lancet (2003) 2.35
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev (2006) 2.20
Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol (2002) 2.10
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell (2003) 2.07
Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein. Nature (2007) 2.05
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
Template boundary definition in Tetrahymena telomerase. Genes Dev (2002) 1.96
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. Mol Cell (2011) 1.87
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell (2007) 1.87
Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol Cell (2003) 1.86
Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev (2004) 1.86
Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs. Nat Struct Mol Biol (2007) 1.80
RNA-based affinity purification reveals 7SK RNPs with distinct composition and regulation. RNA (2007) 1.77
A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65
Telomerase recognizes its template by using an adjacent RNA motif. Proc Natl Acad Sci U S A (2002) 1.61
Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J Biol Chem (2005) 1.58
Biogenesis of telomerase ribonucleoproteins. RNA (2012) 1.47
Specificity requirements for human telomere protein interaction with telomerase holoenzyme. J Biol Chem (2012) 1.47
Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure. BMC Genomics (2008) 1.40
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell (2009) 1.39
A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nat Struct Mol Biol (2005) 1.35
Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes Dev (2009) 1.34
The architecture of Tetrahymena telomerase holoenzyme. Nature (2013) 1.32
A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo. Genes Dev (2010) 1.30
Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. Genes Dev (2007) 1.27
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol (2010) 1.22
Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Hum Genet (2004) 1.22
Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme. Mol Cell Biol (2005) 1.22
High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase. Proc Natl Acad Sci U S A (2007) 1.21
Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association. Genes Dev (2006) 1.21
Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. J Biol Chem (2010) 1.19
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function. RNA (2006) 1.17
Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem (2009) 1.17
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila. G3 (Bethesda) (2011) 1.16
A novel RNA binding domain in tetrahymena telomerase p65 initiates hierarchical assembly of telomerase holoenzyme. Mol Cell Biol (2006) 1.16
Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate. J Biol Chem (2003) 1.14
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. Mol Cell Biol (2012) 1.11
Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex. EMBO J (2014) 1.09
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell (2012) 1.06
The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation. Mol Cell Biol (2010) 1.04
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA. Nucleic Acids Res (2010) 1.04
Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA (2010) 1.02
tRNA binding, structure, and localization of the human interferon-induced protein IFIT5. Mol Cell (2013) 1.01
Structured non-coding RNAs and the RNP Renaissance. Curr Opin Chem Biol (2008) 1.01
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A (2011) 1.00
Positive and negative regulation of Tetrahymena telomerase holoenzyme. Mol Cell Biol (2007) 0.99
Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. Mol Cell Biol (2008) 0.98
Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Mol Cell Biol (2013) 0.90
Initiation by a eukaryotic RNA-dependent RNA polymerase requires looping of the template end and is influenced by the template-tailing activity of an associated uridyltransferase. J Biol Chem (2010) 0.90
Roles of telomerase reverse transcriptase N-terminal domain in assembly and activity of Tetrahymena telomerase holoenzyme. J Biol Chem (2012) 0.90
Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena. Mol Biol Cell (2011) 0.86
Biochemical approaches including the design and use of strains expressing epitope-tagged proteins. Methods Cell Biol (2012) 0.85
Constitutive secretion in Tetrahymena thermophila. Eukaryot Cell (2010) 0.85
Study protocol: the effects of work-site exercise on the physical fitness and work-ability of older workers. BMC Musculoskelet Disord (2007) 0.81
Biochemical properties of Trypanosoma cruzi telomerase. Nucleic Acids Res (2004) 0.78
Strand-asymmetric endogenous Tetrahymena small RNA production requires a previously uncharacterized uridylyltransferase protein partner. RNA (2012) 0.76
Difference in quality of life of referred hospital patients after hospital palliative care team intervention. S Afr Med J (2006) 0.75
Provision of cardiovascular genetic counseling services: current practice and future directions. J Genet Couns (2014) 0.75