Published in Nature on February 25, 2007
Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature (2008) 2.94
Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol (2011) 2.43
RNA dynamics: it is about time. Curr Opin Struct Biol (2008) 2.31
Functional complexity and regulation through RNA dynamics. Nature (2012) 2.07
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. Mol Cell (2011) 1.87
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochim Biophys Acta (2010) 1.58
Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev (2007) 1.56
Biogenesis of telomerase ribonucleoproteins. RNA (2012) 1.47
A comprehensive analysis of the La-motif protein superfamily. RNA (2009) 1.44
The solution structural ensembles of RNA kink-turn motifs and their protein complexes. Nat Chem Biol (2016) 1.41
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell (2009) 1.39
The architecture of Tetrahymena telomerase holoenzyme. Nature (2013) 1.32
Ultra-stable organic fluorophores for single-molecule research. Chem Soc Rev (2014) 1.31
Visualizing the splicing of single pre-mRNA molecules in whole cell extract. RNA (2007) 1.29
Protein-guided RNA dynamics during early ribosome assembly. Nature (2014) 1.26
Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation. EMBO Rep (2011) 1.24
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol (2010) 1.22
Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. J Biol Chem (2010) 1.19
Single Molecule Analysis Research Tool (SMART): an integrated approach for analyzing single molecule data. PLoS One (2012) 1.17
Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. RNA (2007) 1.17
A single-molecule assay for telomerase structure-function analysis. Nucleic Acids Res (2009) 1.14
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol (2011) 1.14
Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes. Nature (2012) 1.12
Single-molecule FRET of protein-nucleic acid and protein-protein complexes: surface passivation and immobilization. Methods (2010) 1.11
Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis. Nat Struct Mol Biol (2011) 1.09
RNA-protein binding interface in the telomerase ribonucleoprotein. Proc Natl Acad Sci U S A (2011) 1.06
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell (2012) 1.06
Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol (2010) 1.06
Single-stranded DNA repeat synthesis by telomerase. Curr Opin Chem Biol (2011) 1.05
Structural basis of the non-coding RNA RsmZ acting as a protein sponge. Nature (2014) 1.04
Hierarchy of RNA functional dynamics. Annu Rev Biochem (2014) 1.04
Precursor-product discrimination by La protein during tRNA metabolism. Nat Struct Mol Biol (2009) 1.02
Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA (2010) 1.02
Ariadne: a database search engine for identification and chemical analysis of RNA using tandem mass spectrometry data. Nucleic Acids Res (2009) 1.00
A two-stage mechanism of viral RNA compaction revealed by single molecule fluorescence. RNA Biol (2013) 0.98
Pseudoknot structures with conserved base triples in telomerase RNAs of ciliates. Nucleic Acids Res (2007) 0.96
Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition. RNA (2009) 0.96
Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain. Angew Chem Int Ed Engl (2012) 0.96
Functional importance of telomerase pseudoknot revealed by single-molecule analysis. Proc Natl Acad Sci U S A (2011) 0.95
A stimulatory role for the La-related protein 4B in translation. RNA (2010) 0.94
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science (2015) 0.92
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function. Nucleic Acids Res (2013) 0.91
The C-terminal domain of Tetrahymena thermophila telomerase holoenzyme protein p65 induces multiple structural changes in telomerase RNA. RNA (2012) 0.91
Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo. RNA (2012) 0.90
Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7. Nucleic Acids Res (2013) 0.90
RNA chaperone activity of human La protein is mediated by variant RNA recognition motif. J Biol Chem (2011) 0.87
xRRM: a new class of RRM found in the telomerase La family protein p65. RNA Biol (2013) 0.87
New models of Tetrahymena telomerase RNA from experimentally derived constraints and modeling. J Am Chem Soc (2012) 0.86
A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition. J Biol Chem (2013) 0.85
Single-molecule analysis of telomerase structure and function. Curr Opin Chem Biol (2011) 0.84
A new telomerase RNA element that is critical for telomere elongation. Nucleic Acids Res (2013) 0.83
RNA reactions one molecule at a time. Cold Spring Harb Perspect Biol (2010) 0.83
Evolutionary perspectives of telomerase RNA structure and function. RNA Biol (2016) 0.83
LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation. RNA (2015) 0.81
Single-Molecule Fluorescence Studies of RNA: A Decade's Progress. Chem Phys Lett (2009) 0.81
A methods review on use of nonsense suppression to study 3' end formation and other aspects of tRNA biogenesis. Gene (2014) 0.80
Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays. J Biol Chem (2012) 0.80
Progress in structural studies of telomerase. Curr Opin Struct Biol (2014) 0.79
Analysis of RNA folding and ribonucleoprotein assembly by single-molecule fluorescence spectroscopy. Methods Mol Biol (2012) 0.79
hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA. Nucleic Acids Res (2016) 0.79
G-register exchange dynamics in guanine quadruplexes. Nucleic Acids Res (2016) 0.78
Structure and folding of the Tetrahymena telomerase RNA pseudoknot. Nucleic Acids Res (2016) 0.78
Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe. Anal Biochem (2011) 0.77
Progress in Human and Tetrahymena Telomerase Structure. Annu Rev Biophys (2017) 0.76
Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. Elife (2016) 0.76
The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA (2017) 0.76
Single-Molecule Studies of Telomeres and Telomerase. Annu Rev Biophys (2017) 0.75
Proximal disruptor aided ligation (ProDAL) of kilobase-long RNAs. RNA Biol (2016) 0.75
The lighthouse at the end of the chromosome. F1000Res (2015) 0.75
The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes. Nucleic Acids Res (2016) 0.75
Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis. RNA (2016) 0.75
Deciphering Complexity in Molecular Biophysics with Single-Molecule Resolution. J Mol Biol (2015) 0.75
Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function. Biophys Rev (2009) 0.75
Energy transfer: a spectroscopic ruler. Proc Natl Acad Sci U S A (1967) 11.78
A telomerase component is defective in the human disease dyskeratosis congenita. Nature (1999) 7.91
Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor. Proc Natl Acad Sci U S A (1996) 7.65
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature (1999) 3.59
Beginning to understand the end of the chromosome. Cell (2004) 3.46
An assembly landscape for the 30S ribosomal subunit. Nature (2005) 3.33
Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19
The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol (2006) 2.94
Telomere maintenance and disease. Lancet (2003) 2.35
Joining of RNAs by splinted ligation. Methods Enzymol (2000) 2.06
Single-molecule RNA science. Annu Rev Biophys Biomol Struct (2005) 1.93
Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol Cell (2003) 1.86
Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev (2004) 1.86
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry (2001) 1.58
Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J Biol Chem (2005) 1.58
Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans. Mol Cell Biol (2003) 1.49
Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J (2006) 1.49
Protein-independent folding pathway of the 16S rRNA 5' domain. J Mol Biol (2005) 1.47
Biochemical aspects of telomerase function. Cancer Lett (2003) 1.43
A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nat Struct Mol Biol (2005) 1.35
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry (2003) 1.24
Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme. Mol Cell Biol (2005) 1.22
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function. RNA (2006) 1.17
Tracking telomerase. Cell (2004) 1.10
Phylogenetic relationships amongst tetrahymenine ciliates inferred by a comparison of telomerase RNAs. Int J Syst Evol Microbiol (2002) 1.08
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat Methods (2006) 30.70
Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science (2008) 14.73
Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science (2007) 9.00
Short-range spectroscopic ruler based on a single-molecule optical switch. Phys Rev Lett (2005) 6.08
Breaking the diffraction barrier: super-resolution imaging of cells. Cell (2010) 5.83
Super-resolution fluorescence microscopy. Annu Rev Biochem (2009) 5.47
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nat Methods (2011) 5.25
Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution. Nat Methods (2008) 4.96
Fast, three-dimensional super-resolution imaging of live cells. Nat Methods (2011) 4.52
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science (2011) 4.26
Visualizing infection of individual influenza viruses. Proc Natl Acad Sci U S A (2003) 4.10
Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons. Science (2012) 4.07
Electrical detection of single viruses. Proc Natl Acad Sci U S A (2004) 3.83
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell (2006) 3.83
Superresolution imaging of chemical synapses in the brain. Neuron (2010) 3.51
Imaging poliovirus entry in live cells. PLoS Biol (2007) 3.40
Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature (2008) 2.94
Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates. Science (2008) 2.78
Exploring the folding landscape of a structured RNA. Proc Natl Acad Sci U S A (2001) 2.78
Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathog (2008) 2.77
Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat Struct Mol Biol (2004) 2.77
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeleton. Nat Methods (2012) 2.67
Virus trafficking - learning from single-virus tracking. Nat Rev Microbiol (2007) 2.59
Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. Proc Natl Acad Sci U S A (2012) 2.46
Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol (2011) 2.43
Chromosome organization by a nucleoid-associated protein in live bacteria. Science (2011) 2.41
Endocytosis of influenza viruses. Microbes Infect (2004) 2.38
Molecular architecture and assembly principles of Vibrio cholerae biofilms. Science (2012) 2.36
Telomere maintenance and disease. Lancet (2003) 2.35
Single-molecule transition-state analysis of RNA folding. Proc Natl Acad Sci U S A (2003) 2.31
Starvation-induced cleavage of the tRNA anticodon loop in Tetrahymena thermophila. J Biol Chem (2005) 2.26
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev (2006) 2.20
Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distance. Proc Natl Acad Sci U S A (2004) 2.11
Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol (2002) 2.10
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell (2003) 2.07
Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol (2007) 2.03
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
Template boundary definition in Tetrahymena telomerase. Genes Dev (2002) 1.96
Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A (2008) 1.88
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. Mol Cell (2011) 1.87
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell (2007) 1.87
Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol Cell (2003) 1.86
Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev (2004) 1.86
Photoswitching mechanism of cyanine dyes. J Am Chem Soc (2009) 1.86
Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs. Nat Struct Mol Biol (2007) 1.80
RNA-based affinity purification reveals 7SK RNPs with distinct composition and regulation. RNA (2007) 1.77
Using single-particle tracking to study nuclear trafficking of viral genes. Biophys J (2004) 1.72
Dynamics of nucleosome remodelling by individual ACF complexes. Nature (2009) 1.68
Exploration of the transition state for tertiary structure formation between an RNA helix and a large structured RNA. J Mol Biol (2003) 1.67
A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65
Internalization and trafficking of cell surface proteoglycans and proteoglycan-binding ligands. Traffic (2007) 1.64
Telomerase recognizes its template by using an adjacent RNA motif. Proc Natl Acad Sci U S A (2002) 1.61
Statistical deconvolution for superresolution fluorescence microscopy. Biophys J (2012) 1.61
Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J Biol Chem (2005) 1.58
Ultrabright photoactivatable fluorophores created by reductive caging. Nat Methods (2012) 1.57
Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nat Cell Biol (2010) 1.55
Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic "fingerprinting". Proc Natl Acad Sci U S A (2007) 1.48
Biogenesis of telomerase ribonucleoproteins. RNA (2012) 1.47
Specificity requirements for human telomere protein interaction with telomerase holoenzyme. J Biol Chem (2012) 1.47
Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. Curr Opin Chem Biol (2008) 1.46
Single-molecule RNA folding. Acc Chem Res (2005) 1.43
Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure. BMC Genomics (2008) 1.40
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell (2009) 1.39
A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nat Struct Mol Biol (2005) 1.35
Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection. Chemphyschem (2011) 1.34
Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes Dev (2009) 1.34
The architecture of Tetrahymena telomerase holoenzyme. Nature (2013) 1.32
A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo. Genes Dev (2010) 1.30
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Cell (2013) 1.29
Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. Genes Dev (2007) 1.27
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol (2010) 1.22
Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Hum Genet (2004) 1.22
Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme. Mol Cell Biol (2005) 1.22
High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase. Proc Natl Acad Sci U S A (2007) 1.21
Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association. Genes Dev (2006) 1.21
Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. J Biol Chem (2010) 1.19
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function. RNA (2006) 1.17
Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem (2009) 1.17
Two distinct binding modes of a protein cofactor with its target RNA. J Mol Biol (2006) 1.17
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila. G3 (Bethesda) (2011) 1.16
A novel RNA binding domain in tetrahymena telomerase p65 initiates hierarchical assembly of telomerase holoenzyme. Mol Cell Biol (2006) 1.16
Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription. Nat Struct Mol Biol (2010) 1.15
Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate. J Biol Chem (2003) 1.14
A single-molecule assay for telomerase structure-function analysis. Nucleic Acids Res (2009) 1.14
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. Mol Cell Biol (2012) 1.11
Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex. EMBO J (2014) 1.09
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell (2012) 1.06
The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation. Mol Cell Biol (2010) 1.04
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA. Nucleic Acids Res (2010) 1.04
Fast compressed sensing analysis for super-resolution imaging using L1-homotopy. Opt Express (2013) 1.04
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob Agents Chemother (2010) 1.03
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains. Nat Struct Mol Biol (2013) 1.03
Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA (2010) 1.02
3D multicolor super-resolution imaging offers improved accuracy in neuron tracing. PLoS One (2012) 1.01
Structured non-coding RNAs and the RNP Renaissance. Curr Opin Chem Biol (2008) 1.01
tRNA binding, structure, and localization of the human interferon-induced protein IFIT5. Mol Cell (2013) 1.01
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A (2011) 1.00