Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

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Published in EMBO J on July 25, 2014

Authors

Sandra Blanco1, Sabine Dietmann1, Joana V Flores1, Shobbir Hussain1, Claudia Kutter2, Peter Humphreys1, Margus Lukk2, Patrick Lombard1, Lucas Treps3, Martyna Popis1, Stefanie Kellner4, Sabine M Hölter5, Lillian Garrett5, Wolfgang Wurst6, Lore Becker7, Thomas Klopstock8, Helmut Fuchs7, Valerie Gailus-Durner7, Martin Hrabĕ de Angelis7, Ragnhildur T Káradóttir1, Mark Helm4, Jernej Ule9, Joseph G Gleeson10, Duncan T Odom2, Michaela Frye11

Author Affiliations

1: Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
2: Li Ka Shing Centre, CR-UK Cambridge Institute, University of Cambridge, Cambridge, UK.
3: CNRS, UMR8104, Paris, France.
4: Johannes Gutenberg University Mainz, Institute for Pharmacy and Biochemistry, Mainz, Germany.
5: German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
6: German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany German Center for Vertigo and Balance Disorders, Munich, Germany.
7: German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany Institute for Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
8: German Center for Vertigo and Balance Disorders, Munich, Germany Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich, Germany.
9: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
10: Laboratory of Pediatric Brain Diseases, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
11: Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK Michaela.Frye@cancer.org.uk mf364@cam.ac.uk.

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