Published in J Biol Chem on May 23, 2005
When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86
Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell (2014) 3.68
The multiple levels of regulation by p53 ubiquitination. Cell Death Differ (2010) 1.87
Ubiquitination and degradation of mutant p53. Mol Cell Biol (2007) 1.77
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell (2005) 1.52
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nat Cell Biol (2009) 1.51
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. J Biol Chem (2012) 1.44
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet (2008) 1.43
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol (2009) 1.41
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun (2013) 1.19
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS One (2012) 1.11
Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev (2014) 1.10
Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem (2011) 1.06
CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Mol Cell Biol (2009) 1.05
Quality control and fate determination of Hsp90 client proteins. Biochim Biophys Acta (2011) 1.04
Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. Proc Natl Acad Sci U S A (2011) 1.04
GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene (2013) 1.03
Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep (2013) 1.00
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem (2010) 0.99
Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP. Biochem J (2006) 0.99
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res (2012) 0.98
E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes. J Biol Chem (2011) 0.97
Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation. Mol Cell Biol (2006) 0.97
CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR. Oncotarget (2014) 0.97
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. J Biol Chem (2007) 0.95
Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. Biochemistry (2007) 0.95
Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program. J Biol Chem (2009) 0.93
Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer. Carcinogenesis (2013) 0.93
E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients. J Biol Chem (2011) 0.91
C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. J Biol Chem (2009) 0.91
Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis. J Cancer Res Clin Oncol (2013) 0.91
Does control of mutant p53 by Mdm2 complicate cancer therapy? Genes Dev (2008) 0.90
Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP. J Biol Chem (2010) 0.90
Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. Biochem J (2006) 0.89
Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) impairs p53 degradation. J Cell Biochem (2009) 0.89
K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep (2015) 0.88
Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Arch Biochem Biophys (2010) 0.86
Cellular responses to misfolded proteins and protein aggregates. Methods Mol Biol (2012) 0.86
CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cells. PLoS One (2013) 0.86
Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther (2010) 0.85
Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G. Chem Biol (2015) 0.85
Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells. Oncotarget (2015) 0.84
Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3. PLoS One (2011) 0.84
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. Nat Cell Biol (2016) 0.84
Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. J Biol Chem (2014) 0.83
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes Cancer (2012) 0.83
Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). J Biol Chem (2013) 0.82
RING finger protein 31 promotes p53 degradation in breast cancer cells. Oncogene (2015) 0.80
S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability. Cell Death Dis (2014) 0.80
UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget (2016) 0.78
Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma. Oncol Lett (2013) 0.78
Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP). Mol Cell Proteomics (2015) 0.78
The BAG-1 cochaperone is a negative regulator of p73-dependent transcription. Br J Cancer (2009) 0.77
CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase. Aging Cell (2015) 0.77
Essential Roles of E3 Ubiquitin Ligases in p53 Regulation. Int J Mol Sci (2017) 0.77
Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells. Anat Cell Biol (2011) 0.77
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. Cell Stress Chaperones (2015) 0.76
Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia. Cell Mol Neurobiol (2011) 0.76
Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein. Sci Rep (2016) 0.76
CHIP: A new modulator of human malignant disorders. Oncotarget (2016) 0.75
A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov (2016) 0.75
Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy. Mol Ther Oncolytics (2017) 0.75
A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? Front Mol Neurosci (2016) 0.75
Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer. Mol Cancer Ther (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem Sci (2002) 3.01
Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A (2003) 2.73
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. Nat Cell Biol (2003) 1.82
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J (2002) 1.81
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature (2002) 1.80
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene (2003) 1.78
Role of the histone acetyl transferase Tip60 in the p53 pathway. J Biol Chem (2004) 1.56
Cooperation of molecular chaperones with the ubiquitin/proteasome system. Biochim Biophys Acta (2004) 1.53
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell (2005) 1.52
The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell (2004) 1.52
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol (2013) 1.43
Involvement of the DNA repair protein hHR23 in p53 degradation. Mol Cell Biol (2003) 1.38
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome. Curr Biol (2005) 1.33
Chaperone-assisted degradation: multiple paths to destruction. Biol Chem (2010) 1.32
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol (2006) 1.31
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones (2003) 1.27
UBE1L2, a novel E1 enzyme specific for ubiquitin. J Biol Chem (2007) 1.25
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins. J Biol Chem (2006) 1.23
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2008) 1.17
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics (2005) 1.13
Pathophysiology of protein aggregation and extended phenotyping in filaminopathy. Brain (2012) 1.12
Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res (2009) 1.12
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem (2007) 1.08
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A (2010) 1.07
Synthesis of defined ubiquitin dimers. J Am Chem Soc (2010) 1.01
Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. Proc Natl Acad Sci U S A (2013) 0.99
Mutation of HERC2 causes developmental delay with Angelman-like features. J Med Genet (2012) 0.98
Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. J Biol Chem (2011) 0.98
Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol (2005) 0.95
Tension-induced autophagy: may the chaperone be with you. Autophagy (2013) 0.93
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
The Hsc/Hsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells. PLoS One (2011) 0.91
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol (2005) 0.91
Ubiquitin ligase E6-AP and its role in human disease. Biochem Soc Trans (2008) 0.90
Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle. Autophagy (2015) 0.90
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell (2013) 0.88
The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids. FEBS Lett (2003) 0.88
Identification of a keratin-associated protein with a putative role in vesicle transport. Eur J Cell Biol (2007) 0.88
Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem (2011) 0.88
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol (2007) 0.87
The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation. Hum Mutat (2010) 0.86
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem (2010) 0.86
Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks. Bioconjug Chem (2009) 0.85
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J (2014) 0.84
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew Chem Int Ed Engl (2014) 0.83
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein. J Mol Med (Berl) (2008) 0.83
Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization. J Struct Biol (2013) 0.83
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer. Mol Ther (2005) 0.82
Differentiation of compact and extended conformations of di-ubiquitin conjugates with lysine-specific isopeptide linkages by ion mobility-mass spectrometry. J Am Soc Mass Spectrom (2011) 0.81
Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations. Autophagy (2012) 0.81
UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM. FEBS J (2012) 0.81
Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells. Biotechniques (2009) 0.81
c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity. Biochemistry (2013) 0.80
Oncogenic human papillomaviruses block expression of the B-cell translocation gene-2 tumor suppressor gene. Int J Cancer (2009) 0.79
Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells. Commun Integr Biol (2013) 0.79
Formation of ubiquitin dimers via azide-alkyne click reaction. Methods Mol Biol (2012) 0.78
Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53. Subcell Biochem (2010) 0.77
Identification of the mitochondrial MSRB2 as a binding partner of LG72. Cell Mol Neurobiol (2014) 0.77
Analysis of chaperone-assisted ubiquitylation. Methods Mol Biol (2012) 0.76
Improving bioorthogonal protein ubiquitylation by click reaction. Bioorg Med Chem (2013) 0.76
Fluorogenic ATP analogues for online monitoring of ATP consumption: observing ubiquitin activation in real time. Angew Chem Int Ed Engl (2013) 0.75
Varshavsky's contributions. Science (2004) 0.75
Selective monitoring of the enzymatic activity of the tumor suppressor Fhit. Angew Chem Int Ed Engl (2014) 0.75
Molecular chaperones in the regulation of signal transduction. Ann N Y Acad Sci (2002) 0.75