Published in Proc Natl Acad Sci U S A on May 18, 2006
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The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
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Poliovirus 2C protein forms homo-oligomeric structures required for ATPase activity. J Biol Chem (2009) 0.97
Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. Mol Biol Cell (2009) 0.96
Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. Proc Natl Acad Sci U S A (2012) 0.93
ERAD and how viruses exploit it. Front Microbiol (2014) 0.91
Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase. Glycobiology (2008) 0.90
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Protein quality control: the who's who, the where's and therapeutic escapes. Histochem Cell Biol (2007) 0.85
N-terminal deletion of peptide:N-glycanase results in enhanced deglycosylation activity. PLoS One (2009) 0.82
The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. J Biol Chem (2010) 0.81
Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer. PLoS One (2015) 0.77
Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice. J Integr Plant Biol (2015) 0.77
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 2.81
A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J (2003) 2.18
Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol (2005) 2.12
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem (2004) 2.07
Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol (2005) 2.06
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol (2000) 1.98
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J (2004) 1.68
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J (2004) 1.53
p97, a protein coping with multiple identities. J Cell Sci (2003) 1.45
The Png1-Rad23 complex regulates glycoprotein turnover. J Cell Biol (2006) 1.43
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol (2004) 1.42
Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Proc Natl Acad Sci U S A (2001) 1.34
Cytoplasmic peptide:N-glycanase (PNGase) in eukaryotic cells: occurrence, primary structure, and potential functions. FASEB J (2002) 1.33
Checkpoints in ER-associated degradation: excuse me, which way to the proteasome? Trends Cell Biol (2004) 1.29
Yeast N-glycanase distinguishes between native and non-native glycoproteins. EMBO Rep (2004) 1.18
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics (2005) 1.13
The PUB domain: a putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun (2001) 1.08
A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J (2004) 1.08
A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2004) 1.04
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation. FEBS Lett (2005) 0.98
Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Proc Natl Acad Sci U S A (2005) 0.86
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab (2006) 4.64
A comparative anatomic study of a modified temporal-occipital transtentorial transpetrosal-ridge approach and a transpetrosal presigmoid approach. World Neurosurg (2011) 3.30
Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo. Nature (2004) 2.69
Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans. Proc Natl Acad Sci U S A (2004) 2.51
The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell (2006) 2.31
Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes. Cell (2008) 2.28
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. Proc Natl Acad Sci U S A (2006) 2.16
The prevalence and burden of primary headaches in China: a population-based door-to-door survey. Headache (2012) 2.04
Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process. J Biol Chem (2002) 1.80
The burden of headache in China: validation of diagnostic questionnaire for a population-based survey. J Headache Pain (2011) 1.67
Unraveling the mechanism of protein N-glycosylation. J Biol Chem (2004) 1.61
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a. J Biol Chem (2007) 1.59
ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications. J Am Chem Soc (2009) 1.54
Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein. Hypertens Res (2011) 1.50
Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: role of mitochondrial permeability transition. Crit Care Med (2012) 1.48
The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. Biochemistry (2008) 1.44
Mediation of multiple pathways regulating cell proliferation, migration, and apoptosis in the human malignant glioma cell line U87MG via unphosphorylated STAT1: laboratory investigation. J Neurosurg (2013) 1.44
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett (2003) 1.42
Expression of snail in pancreatic cancer promotes metastasis and chemoresistance. J Surg Res (2007) 1.40
Value of myocardial regional perfusion on long-term function in collateral-dependent myocardium. South Med J (2008) 1.40
Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system. J Neurosci (2003) 1.40
Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. J Biol Chem (2004) 1.36
Cytoplasmic peptide:N-glycanase (PNGase) in eukaryotic cells: occurrence, primary structure, and potential functions. FASEB J (2002) 1.33
Obstructive sleep apnea and risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies. Int J Cardiol (2013) 1.29
Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinoma. J Cancer Res Clin Oncol (2009) 1.26
The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin. J Neurosci (2011) 1.25
Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neurosci Res (2009) 1.23
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2007) 1.21
Reactivity and chemical synthesis of L-pyrrolysine- the 22(nd) genetically encoded amino acid. Chem Biol (2004) 1.19
Persistence of side population cells with high drug efflux capacity in pancreatic cancer. World J Gastroenterol (2008) 1.18
The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor. J Mol Biol (2006) 1.16
A meta-analysis of gemcitabine containing chemotherapy for locally advanced and metastatic pancreatic adenocarcinoma. J Hematol Oncol (2011) 1.15
Hierarchical binding of cofactors to the AAA ATPase p97. Structure (2011) 1.14
Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis. Curr Opin Struct Biol (2002) 1.13
Structural basis of assembly chaperone- mediated snRNP formation. Mol Cell (2013) 1.13
The catalytic activity of protein-disulfide isomerase requires a conformationally flexible molecule. J Biol Chem (2008) 1.12
Deciphering the structural framework of glycine receptor anchoring by gephyrin. EMBO J (2006) 1.12
Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats. Neurochem Int (2010) 1.11
Asymmetric [3+2] cycloadditions of allenoates and dual activated olefins catalyzed by simple bifunctional N-acyl aminophosphines. Angew Chem Int Ed Engl (2010) 1.10
Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. Proc Natl Acad Sci U S A (2002) 1.10
Structure of the oligosaccharyl transferase complex at 12 A resolution. Structure (2008) 1.10
Specificity of pyrrolysyl-tRNA synthetase for pyrrolysine and pyrrolysine analogs. J Mol Biol (2008) 1.08
Gephyrin, the enigmatic organizer at GABAergic synapses. Front Cell Neurosci (2012) 1.07
Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology (2011) 1.07
Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys. Arterioscler Thromb Vasc Biol (2007) 1.07
An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation. Proc Natl Acad Sci U S A (2009) 1.06
Body mass index and migraine: a survey of the Chinese adult population. J Headache Pain (2012) 1.06
microRNA-181a represses ox-LDL-stimulated inflammatory response in dendritic cell by targeting c-Fos. J Lipid Res (2012) 1.05
Headache yesterday in China: a new approach to estimating the burden of headache, applied in a general-population survey in China. Cephalalgia (2013) 1.04
A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2004) 1.04
Meta-modeling soil organic carbon sequestration potential and its application at regional scale. Ecol Appl (2013) 1.03
Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2003) 1.02
Nonlinear optical microscopy for histology of fresh normal and cancerous pancreatic tissues. PLoS One (2012) 1.02
Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin. J Biol Chem (2004) 1.02
Dimeric organization of the yeast oligosaccharyl transferase complex. Proc Natl Acad Sci U S A (2006) 1.02
Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons. Glycobiology (2005) 1.02
The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression. PLoS One (2011) 1.02
Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. Proc Natl Acad Sci U S A (2006) 1.01
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology (2012) 1.01
Pharmacokinetics and tissue distribution of PGG-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts. Cancer Chemother Pharmacol (2009) 1.01
Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J Biol Chem (2006) 1.01
Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine. Int J Mol Sci (2011) 1.00
Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin. J Biol Chem (2011) 1.00
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release (2009) 0.99
Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane. Cancer Chemother Pharmacol (2009) 0.99
Site-directed mutagenesis study of yeast peptide:N-glycanase. Insight into the reaction mechanism of deglycosylation. J Biol Chem (2002) 0.99
Rational design, structural and thermodynamic characterization of a hyperstable variant of the villin headpiece helical subdomain. Biochemistry (2007) 0.99
Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. Proc Natl Acad Sci U S A (2012) 0.99
The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem (2011) 0.98
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation. FEBS Lett (2005) 0.98
The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies. BMC Gastroenterol (2014) 0.98
The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum. Mol Biol Cell (2005) 0.98
Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. J Biol Chem (2003) 0.97
Subunits of the translocon interact with components of the oligosaccharyl transferase complex. J Biol Chem (2005) 0.97
Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b. Biochem J (2008) 0.96
Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res (2004) 0.96
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. J Alzheimers Dis (2013) 0.96
Catheter-based adenovirus-mediated anti-monocyte chemoattractant gene therapy attenuates in-stent neointima formation in cynomolgus monkeys. Atherosclerosis (2006) 0.95
Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents. Hepatology (2013) 0.95
The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain. J Biol Chem (2010) 0.95
Structural basis for the function of a minimembrane protein subunit of yeast oligosaccharyltransferase. Proc Natl Acad Sci U S A (2004) 0.95
Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics (2011) 0.95
A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid. J Clin Microbiol (2012) 0.95
Health-care utilization for primary headache disorders in China: a population-based door-to-door survey. J Headache Pain (2013) 0.94
Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2. Microb Pathog (2009) 0.94
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. J Med Chem (2012) 0.94