Published in Mol Cell Biol on December 01, 2005
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
Notch signaling at a glance. J Cell Sci (2013) 1.76
Eloquent silence: developmental functions of Class I histone deacetylases. Curr Opin Genet Dev (2008) 1.74
Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.60
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
Transcriptional control of stem cell maintenance in the Drosophila intestine. Development (2010) 1.48
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32
Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep (2013) 1.32
Signaling and epigenetic regulation of pituitary development. Curr Opin Cell Biol (2007) 1.02
Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J (2008) 1.02
Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development (2010) 1.01
Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density. PLoS One (2010) 0.99
Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes. Genetics (2007) 0.99
The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation. Development (2012) 0.93
putzig is required for cell proliferation and regulates notch activity in Drosophila. Mol Biol Cell (2007) 0.92
A novel Pzg-NURF complex regulates Notch target gene activity. Mol Biol Cell (2010) 0.90
The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster. Genetics (2011) 0.88
CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci (2012) 0.87
Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification. Mol Cell Biol (2010) 0.87
Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. Mol Biol Cell (2011) 0.87
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn (2011) 0.86
The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription. PLoS Genet (2014) 0.86
The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster. BMC Evol Biol (2008) 0.84
Planar cell polarity controls directional Notch signaling in the Drosophila leg. Development (2012) 0.83
Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor. Development (2008) 0.82
Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development. Development (2009) 0.81
Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities. PLoS One (2013) 0.80
Hairless is a cofactor for Runt-dependent transcriptional regulation. Mol Biol Cell (2011) 0.79
Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. PLoS One (2011) 0.79
The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion. Elife (2016) 0.78
Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS Biol (2016) 0.78
Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters. Mol Cell Biol (2010) 0.78
Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development. Dev Dyn (2010) 0.77
The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub. J Biol Chem (2015) 0.77
Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster. PLoS One (2015) 0.76
Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology. J Cancer Res Clin Oncol (2015) 0.76
Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex. PLoS Biol (2016) 0.76
Local overexpression of Su(H)-MAPK variants affects Notch target gene expression and adult phenotypes in Drosophila. Data Brief (2015) 0.76
Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development. PLoS One (2016) 0.76
Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. J Cell Sci (2014) 0.75
In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila. Sci Rep (2016) 0.75
The Transcriptional Coregulator LEUNIG_HOMOLOG Inhibits Light-Dependent Seed Germination in Arabidopsis. Plant Cell (2015) 0.75
Insensible is a novel nuclear inhibitor of Notch activity in Drosophila. PLoS One (2014) 0.75
Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Mol Neurodegener (2016) 0.75
Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster. Development (2017) 0.75
Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types. Development (2013) 0.75
The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway. Cell Div (2016) 0.75
Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila. PLoS One (2015) 0.75
Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity. Sci Rep (2017) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature (2003) 6.48
Notch signaling: from the outside in. Dev Biol (2000) 6.06
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell (1994) 4.95
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol (1996) 4.26
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev (1999) 3.91
Regulation of notch signaling activity. Curr Biol (2004) 3.88
Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res (1988) 3.66
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol Cell Biol (1996) 3.06
Transcriptional repression: the long and the short of it. Genes Dev (2001) 2.91
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev (2002) 2.77
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature (1996) 2.74
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J (1998) 2.74
p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol (2001) 2.64
Gene silencing by double-stranded RNA. Curr Opin Cell Biol (2001) 2.43
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev (1994) 2.08
The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development (1994) 2.07
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem (2003) 2.02
CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat Struct Mol Biol (2005) 1.98
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev (2000) 1.87
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev (2002) 1.87
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol (2001) 1.78
Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo. Proc Natl Acad Sci U S A (1999) 1.72
Hairy transcriptional repression targets and cofactor recruitment in Drosophila. PLoS Biol (2004) 1.63
Bre1 is required for Notch signaling and histone modification. Dev Cell (2005) 1.58
Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics (1991) 1.47
Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J Biol Chem (2000) 1.39
Groucho oligomerization is required for repression in vivo. Mol Cell Biol (2004) 1.36
Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development (1996) 1.34
Dissecting the mechanisms of suppressor of hairless function. Dev Biol (2000) 1.32
Notch pathway: making sense of suppressor of hairless. Curr Biol (2001) 1.22
A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system. Proc Natl Acad Sci U S A (1997) 1.19
Association of class I histone deacetylases with transcriptional corepressor CtBP. FEBS Lett (2003) 1.16
Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation. Proc Natl Acad Sci U S A (2002) 1.15
The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu. Dev Biol (2004) 1.14
Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. EMBO J (2001) 1.14
In vivo structure-function analysis of Drosophila Hairless. Mech Dev (1997) 1.06
Local action of long-range repressors in the Drosophila embryo. EMBO J (2001) 1.03
A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development (2003) 1.02
Green fluorescent protein as a convenient and versatile marker for studies on functional genomics in Drosophila. Dev Genes Evol (2002) 1.02
Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development. Development (2001) 1.02
Subcellular localization of Hairless protein shows a major focus of activity within the nucleus. Mech Dev (1999) 0.96
Scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila. Mech Dev (2001) 0.87
Repression of Dpp targets in the Drosophila wing by Brinker. Development (2004) 0.84
The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes. Nucleic Acids Res (2004) 8.79
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood (2009) 2.25
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye. Curr Biol (2002) 2.10
Data integration in the era of omics: current and future challenges. BMC Syst Biol (2014) 1.82
Evaluating the impact of criminal laws on HIV risk behavior. J Law Med Ethics (2002) 1.62
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci (2011) 1.20
Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling. Development (2003) 1.16
Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation. Proc Natl Acad Sci U S A (2002) 1.15
Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis. J Cell Sci (2008) 1.11
First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: a phase I/II open-label and double-blind study. Eur J Cancer (2012) 1.08
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Development (2013) 1.06
Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol (2009) 1.05
Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. Genetics (2005) 1.04
Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis. J Infect (2006) 1.04
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet (2013) 1.03
Green fluorescent protein as a convenient and versatile marker for studies on functional genomics in Drosophila. Dev Genes Evol (2002) 1.02
Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development (2010) 1.01
Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm (Lond) (2012) 0.97
Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells. J Immunol (2011) 0.96
Dissecting the mechanisms of Notch induced hyperplasia. EMBO J (2012) 0.95
The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med (2014) 0.95
Genetic determinants of major blood lipids in Pakistanis compared with Europeans. Circ Cardiovasc Genet (2010) 0.95
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. J Allergy Clin Immunol (2012) 0.93
Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Gene Expr Patterns (2006) 0.92
The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. BMC Evol Biol (2005) 0.92
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mech Dev (2002) 0.91
Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. Mech Dev (2002) 0.90
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development (2010) 0.90
Protein kinase D regulates several aspects of development in Drosophila melanogaster. BMC Dev Biol (2007) 0.88
Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue. J Cell Biol (2011) 0.88
Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. Lancet Respir Med (2015) 0.88
Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope (2011) 0.87
Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. Mol Biol Cell (2011) 0.87
The enhancer of trithorax and polycomb corto interacts with cyclin G in Drosophila. PLoS One (2008) 0.87
Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1. EMBO Rep (2011) 0.87
Simulation environment and graphical visualization environment: a COPD use-case. J Transl Med (2014) 0.87
The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect Immun (2011) 0.86
Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila. Hereditas (2011) 0.85
A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila. J Cell Sci (2006) 0.84
Drosophila p53 controls Notch expression and balances apoptosis and proliferation. Apoptosis (2014) 0.84
Systems Medicine: from molecular features and models to the clinic in COPD. J Transl Med (2014) 0.84
Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster. Genesis (2004) 0.84
The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster. BMC Evol Biol (2008) 0.84
Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila. Genesis (2002) 0.83
Gluconacetobacter diazotrophicus levansucrase is involved in tolerance to NaCl, sucrose and desiccation, and in biofilm formation. Arch Microbiol (2010) 0.83
Biomedical research in a Digital Health Framework. J Transl Med (2014) 0.83
Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer. Qual Life Res (2012) 0.83
Workforce preparation: the Biohealth computing model for Master and PhD students. J Transl Med (2014) 0.82
Regulation of Abd-B expression by Cyclin G and Corto in the abdominal epithelium of Drosophila. Hereditas (2008) 0.82
Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage. Bioinformatics (2008) 0.81
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. J Transl Med (2014) 0.81
Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities. PLoS One (2013) 0.80
The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. FEMS Immunol Med Microbiol (2008) 0.80
Cyclin G is involved in meiotic recombination repair in Drosophila melanogaster. J Cell Sci (2012) 0.80
Ligand-binding and signaling properties of the Ax[M1] form of Notch. Mech Dev (2005) 0.79
Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. PLoS One (2011) 0.79
Constitutively active protein kinase D acts as negative regulator of the Slingshot-phosphatase in Drosophila. Hereditas (2010) 0.79
Dorso-ventral axis formation of the Drosophila oocyte requires Cyclin G. Hereditas (2012) 0.79
Involvement of co-repressors Groucho and CtBP in the regulation of single-minded in Drosophila. Hereditas (2007) 0.78
TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells. FEMS Microbiol Lett (2009) 0.78
A systems medicine clinical platform for understanding and managing non- communicable diseases. Curr Pharm Des (2014) 0.77
Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless. Hereditas (2014) 0.77
Deletion mapping in the Enhancer of split complex. Hereditas (2014) 0.76
Evaluation of DNA extraction methods of rumen microbial populations. World J Microbiol Biotechnol (2012) 0.76
Systematic Review on the Definition of Allergic Diseases in Children: The MeDALL Study. Int Arch Allergy Immunol (2015) 0.76
Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein. Int J Biol Macromol (2008) 0.76
A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development. J Cell Sci (2013) 0.76
Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol (2015) 0.75
Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless. Hereditas (2014) 0.75
Putting the tissue and environmental 'context' into differentiation and gene regulation. Curr Opin Genet Dev (2008) 0.75