Published in Development on November 16, 2005
A developmental and genetic classification for midbrain-hindbrain malformations. Brain (2009) 2.47
Measured motion: searching for simplicity in spinal locomotor networks. Curr Opin Neurobiol (2009) 2.40
Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol (2012) 2.01
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev (2007) 1.79
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell (2009) 1.59
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev (2012) 1.45
Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc Natl Acad Sci U S A (2007) 1.41
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science (2009) 1.34
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol (2008) 1.31
Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Mol Cell Neurosci (2008) 1.31
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits. Cell (2016) 1.23
Ptf1a triggers GABAergic neuronal cell fates in the retina. BMC Dev Biol (2007) 1.19
Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina. Neural Dev (2009) 1.18
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron (2009) 1.16
Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci (2008) 1.15
FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. PLoS One (2009) 1.13
Transcriptional regulation of neuronal phenotype in mammals. J Physiol (2006) 1.12
From circuits to behaviour: motor networks in vertebrates. Curr Opin Neurobiol (2010) 1.09
Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci (2014) 1.08
Transcription factors define the neuroanatomical organization of the medullary reticular formation. Front Neuroanat (2013) 1.03
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord. Development (2009) 1.02
Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. J Neurosci (2013) 0.98
Origin and determination of inhibitory cell lineages in the vertebrate retina. J Neurosci (2011) 0.98
Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A (2009) 0.98
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Dev Cell (2013) 0.96
A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development (2014) 0.96
Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. J Neurosci (2009) 0.94
RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol (2012) 0.94
Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev Biol (2008) 0.93
Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord. Neuron (2014) 0.92
Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem. PLoS Genet (2013) 0.92
Control of precerebellar neuron development by Olig3 bHLH transcription factor. J Neurosci (2008) 0.91
Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system. J Biol Chem (2009) 0.86
Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function. Proc Natl Acad Sci U S A (2014) 0.86
Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. Mol Pain (2014) 0.86
Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. J Neurosci (2013) 0.85
A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet (2013) 0.85
Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol (2013) 0.83
Molecular and cellular development of spinal cord locomotor circuitry. Front Mol Neurosci (2015) 0.82
A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord. PLoS One (2013) 0.82
The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation. J Biol Chem (2014) 0.81
GABAergic neuron specification in the spinal cord, the cerebellum, and the cochlear nucleus. Neural Plast (2012) 0.81
Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2. Mol Cell Neurosci (2011) 0.81
Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Sci Rep (2015) 0.80
Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Dev Biol (2013) 0.80
Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol (2013) 0.80
Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons. PLoS One (2012) 0.79
Retrotransposon activates ectopic Ptf1 expression: a short tail. PLoS Genet (2013) 0.79
Making sense out of spinal cord somatosensory development. Development (2016) 0.79
Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci (2016) 0.78
From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. Open Biol (2014) 0.77
Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem Cells Dev (2013) 0.77
Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain (2015) 0.77
The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord. PeerJ (2013) 0.77
Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Dev Biol (2008) 0.77
The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex. Somatosens Mot Res (2012) 0.77
Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis. Mol Brain (2015) 0.77
Corticospinal tract insult alters GABAergic circuitry in the mammalian spinal cord. Front Neural Circuits (2013) 0.76
Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity. J Neurosci (2015) 0.76
Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. Neuron (2016) 0.76
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease. Front Neuroanat (2016) 0.76
Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3. Front Neural Circuits (2015) 0.76
Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev (2016) 0.76
Regulating the dorsal neural tube expression of Ptf1a through a distal 3' enhancer. Dev Biol (2016) 0.75
Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem (2013) 0.75
An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system. Neural Dev (2015) 0.75
Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development. Front Neural Circuits (2017) 0.75
Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Dev (2016) 0.75
Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice. Nat Commun (2017) 0.75
Genetically identified spinal interneurons integrating tactile afferents for motor control. J Neurophysiol (2015) 0.75
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet (2002) 4.76
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci (2005) 3.97
Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons. J Neurosci (2010) 3.61
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns (2003) 3.42
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development (2002) 3.41
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev (2006) 3.16
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J (2004) 2.55
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest (2011) 2.54
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
Specification of dorsal spinal cord interneurons. Curr Opin Neurobiol (2003) 2.33
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol (2006) 2.13
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis (2005) 1.90
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev (2006) 1.76
Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development (2007) 1.76
A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract. J Am Soc Nephrol (2002) 1.72
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development (2006) 1.63
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell (2009) 1.59
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes (2005) 1.57
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest (2012) 1.55
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis. J Neurosci (2007) 1.54
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol (2009) 1.46
Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification. Development (2004) 1.43
Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain. PLoS One (2011) 1.42
Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc Natl Acad Sci U S A (2007) 1.41
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development (2003) 1.37
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci U S A (2002) 1.36
Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons. Development (2005) 1.34
Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Mol Cell Neurosci (2008) 1.31
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol (2008) 1.31
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab (2004) 1.31
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A (2012) 1.31
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology (2005) 1.29
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Cerebellum- and forebrain-derived stem cells possess intrinsic regional character. Development (2005) 1.26
Manipulating Robo expression in vivo perturbs commissural axon pathfinding in the chick spinal cord. J Neurosci (2008) 1.24
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol (2002) 1.18
In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Dev Biol (2004) 1.18
Distinct activities of Msx1 and Msx3 in dorsal neural tube development. Development (2004) 1.12
Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development (2011) 1.09
Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development (2011) 1.08
Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle. Genes Dev (2011) 1.08
Xbves is a regulator of epithelial movement during early Xenopus laevis development. Proc Natl Acad Sci U S A (2006) 1.08
Separable enhancer sequences regulate the expression of the neural bHLH transcription factor neurogenin 1. Dev Biol (2004) 1.08
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem (2003) 1.07
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology (2012) 1.07
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1. Development (2005) 1.03
A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs. Gene Expr Patterns (2006) 1.03
Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation. Development (2003) 1.02
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord. Development (2009) 1.02
Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol (2006) 1.01
Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice. Diabetes (2008) 1.01
Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol (2009) 0.99
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. J Neurosci (2011) 0.98
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Dev Cell (2013) 0.96
Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development (2012) 0.96
Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages. Dev Biol (2010) 0.95
Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. J Neurosci (2009) 0.94
β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development (2012) 0.93
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev Biol (2009) 0.92
Notch-independent functions of CSL. Curr Top Dev Biol (2011) 0.92
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system. J Comp Neurol (2011) 0.92
Lineage determinants in early endocrine development. Semin Cell Dev Biol (2012) 0.92
The heat is on: room temperature affects laboratory equipment--an observational study. J Assist Reprod Genet (2013) 0.88
Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Dev Biol (2006) 0.88
Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis (2005) 0.88
Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology (2006) 0.88
Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc Natl Acad Sci U S A (2013) 0.88
PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes (2013) 0.87
Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline. Mol Cell Neurosci (2007) 0.86
Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development (2014) 0.84
Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development (2013) 0.83
Evi-1 expression in Xenopus. Gene Expr Patterns (2005) 0.83