Published in Dev Biol on August 10, 2006
BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning. Dev Cell (2010) 1.67
Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron (2007) 1.23
Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. Development (2011) 1.09
Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. Development (2013) 1.09
APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis. Dev Biol (2010) 0.93
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Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development (1995) 2.16
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning. Cell (2002) 2.16
The zebrafish Nodal signal Squint functions as a morphogen. Nature (2001) 2.16
Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature (1998) 2.10
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Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development (2000) 1.97
Nodal activity in the node governs left-right asymmetry. Genes Dev (2002) 1.95
The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell (1998) 1.95
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell (1998) 1.93
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell (1999) 1.87
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Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science (1999) 1.81
The SIL gene is required for mouse embryonic axial development and left-right specification. Nature (1999) 1.81
Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol Cell (2001) 1.77
Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev (1999) 1.74
Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. Dev Cell (2005) 1.69
SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. Genes Dev (2000) 1.56
Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev Biol (1998) 1.56
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells (2002) 1.51
Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol (2003) 1.41
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Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. Development (1997) 1.23
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Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development (2003) 1.12
Functional differences among Xenopus nodal-related genes in left-right axis determination. Development (1997) 1.12
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PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development. Cell (2002) 1.07
Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node. Development (1999) 1.05
Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo. Curr Biol (2004) 1.05
Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates. Genes Cells (2001) 1.01
Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell (2001) 1.01
Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis. Development (2003) 1.00
An amphioxus nodal gene (AmphiNodal) with early symmetrical expression in the organizer and mesoderm and later asymmetrical expression associated with left-right axis formation. Evol Dev (2002) 0.96
TGF-beta superfamily signaling and left-right asymmetry. Sci STKE (2001) 0.95
The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development (2000) 0.95
Patterning across the ascidian neural plate by lateral Nodal signalling sources. Development (2005) 0.94
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A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. Development (1996) 0.93
Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling. Dev Biol (2000) 0.93
HrNodal, the ascidian nodal-related gene, is expressed in the left side of the epidermis, and lies upstream of HrPitx. Dev Genes Evol (2002) 0.92
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Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements. Mech Dev (2004) 0.88
Maintenance of asymmetric nodal expression in Xenopus laevis. Dev Genet (1998) 0.82
Xenopus nodal related-1 is indispensable only for left-right axis determination. Int J Dev Biol (2005) 0.82
Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction. Mech Dev (2000) 0.82
Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int J Dev Biol (2003) 0.80
Evolutionary conservation of mechanisms upstream of asymmetric Nodal expression: reconciling chick and Xenopus. Dev Genet (1998) 0.76
More than 95% reversal of left-right axis induced by right-sided hypodermic microinjection of activin into Xenopus neurula embryos. Dev Biol (2000) 0.76
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet (2002) 4.76
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev (2006) 3.16
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest (2011) 2.54
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development (2005) 1.90
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis (2005) 1.90
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev (2006) 1.76
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell (2009) 1.59
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol (2009) 1.46
Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc Natl Acad Sci U S A (2007) 1.41
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development (2003) 1.37
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci U S A (2002) 1.36
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab (2004) 1.31
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol (2002) 1.18
Xbves is a regulator of epithelial movement during early Xenopus laevis development. Proc Natl Acad Sci U S A (2006) 1.08
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem (2003) 1.07
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol (2006) 1.01
Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice. Diabetes (2008) 1.01
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev Biol (2009) 0.92
Lineage determinants in early endocrine development. Semin Cell Dev Biol (2012) 0.92
Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis (2005) 0.88
Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology (2006) 0.88
Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc Natl Acad Sci U S A (2013) 0.88
PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes (2013) 0.87
Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development (2014) 0.84
Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development (2013) 0.83
Evi-1 expression in Xenopus. Gene Expr Patterns (2005) 0.83
Nodal-related gene Xnr5 is amplified in the Xenopus genome. Genesis (2006) 0.81
A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis (2012) 0.79
Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling. Dev Dyn (2007) 0.79
Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. Dev Biol (2006) 0.77
Left-right asymmetry: advances and enigmas. Genesis (2014) 0.75