PubRank

Paul Tempst

Author PubWeight™ 440.69‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002 24.31
2 mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 18.22
3 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 16.83
4 Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002 13.08
5 PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008 13.08
6 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007 11.14
7 Histone demethylation by a family of JmjC domain-containing proteins. Nature 2005 10.36
8 Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol 2009 9.67
9 Role of histone H2A ubiquitination in Polycomb silencing. Nature 2004 9.48
10 Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005 7.75
11 Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 2008 7.18
12 Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell 2007 5.78
13 Regulation of p53 activity through lysine methylation. Nature 2004 5.78
14 Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007 5.62
15 PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 2002 5.59
16 JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006 5.54
17 Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol 2002 5.53
18 The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 2006 5.51
19 Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev 2002 5.43
20 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 2004 5.37
21 GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 5.21
22 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 2007 5.20
23 Histone deimination antagonizes arginine methylation. Cell 2004 5.19
24 Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell 2004 5.06
25 Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest 2006 4.37
26 TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 4.16
27 Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol 2002 4.12
28 Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 2002 4.08
29 Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 2002 4.07
30 Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell 2005 4.04
31 Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol 2004 3.90
32 Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008 3.90
33 P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 2002 3.80
34 The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 2007 3.79
35 Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 2004 3.77
36 L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 2007 3.70
37 PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell 2007 3.68
38 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell 2006 3.39
39 An iron delivery pathway mediated by a lipocalin. Mol Cell 2002 3.38
40 Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 2006 3.31
41 The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol 2002 3.13
42 Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res 2010 3.08
43 mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell 2003 2.97
44 A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 2006 2.95
45 Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol 2009 2.91
46 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 2008 2.86
47 Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev 2007 2.81
48 The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature 2002 2.77
49 MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007 2.76
50 SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 2007 2.76
51 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol 2003 2.72
52 The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev 2005 2.70
53 Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 2003 2.66
54 A new role for Nogo as a regulator of vascular remodeling. Nat Med 2004 2.63
55 Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature 2007 2.52
56 Isolation and mass spectrometry of transcription factor complexes. Methods 2002 2.46
57 Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14. EMBO J 2004 2.46
58 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009 2.45
59 PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 2005 2.44
60 Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics 2009 2.39
61 Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 2004 2.39
62 Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 2010 2.38
63 Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev 2006 2.36
64 Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A 2002 2.27
65 The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases. Nat Struct Mol Biol 2008 2.26
66 Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol 2007 2.10
67 The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell 2002 2.10
68 Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics 2009 2.09
69 Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol 2006 2.08
70 Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry. Anal Chem 2004 2.07
71 The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol 2007 1.99
72 A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell 2007 1.98
73 Purification and characterization of the human elongator complex. J Biol Chem 2001 1.97
74 BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J Exp Med 2006 1.93
75 Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell 2005 1.93
76 Correcting common errors in identifying cancer-specific serum peptide signatures. J Proteome Res 2005 1.91
77 LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J 2011 1.89
78 S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proc Natl Acad Sci U S A 2004 1.87
79 Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev 2006 1.85
80 A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem 2002 1.84
81 The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 2004 1.80
82 A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage. Nature 2002 1.80
83 MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 2011 1.68
84 Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 2005 1.68
85 Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 2003 1.60
86 ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell 2005 1.55
87 The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev Cell 2005 1.55
88 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev 2008 1.51
89 The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol Cell Biol 2008 1.47
90 Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell 2013 1.46
91 Role of integrins in the assembly and function of hensin in intercalated cells. J Am Soc Nephrol 2008 1.46
92 Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol Microbiol 2005 1.38
93 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011 1.37
94 Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem 2004 1.36
95 ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol 2003 1.34
96 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell 2011 1.32
97 Serum peptidome patterns that distinguish metastatic thyroid carcinoma from cancer-free controls are unbiased by gender and age. Mol Cell Proteomics 2006 1.31
98 NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int 2012 1.30
99 Architecture of the Mediator head module. Nature 2011 1.30
100 Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem 2009 1.28
101 A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination. Immunity 2005 1.27
102 The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Genetics 2005 1.25
103 CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 2006 1.25
104 A sequence-specific exopeptidase activity test (SSEAT) for "functional" biomarker discovery. Mol Cell Proteomics 2007 1.24
105 PINdb: a database of nuclear protein complexes from human and yeast. Bioinformatics 2004 1.21
106 The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates. Mol Cell Biol 2005 1.20
107 Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem 2007 1.19
108 Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol Cell Biol 2002 1.18
109 Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. J Cell Biol 2005 1.18
110 Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries. Mol Cell Biol 2007 1.18
111 Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 2007 1.15
112 Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell 2007 1.13
113 Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics. Clin Chem 2009 1.10
114 Catalytic properties of ADAM19. J Biol Chem 2003 1.09
115 MTERF2 is a nucleoid component in mammalian mitochondria. Biochim Biophys Acta 2009 1.09
116 Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3. Mol Cell 2008 1.08
117 Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration. Clin Chem 2009 1.07
118 The yeast capping enzyme represses RNA polymerase II transcription. Mol Cell 2002 1.07
119 A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation. Mol Cell Proteomics 2004 1.05
120 Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. J Biol Chem 2004 1.04
121 Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes. Nucleic Acids Res 2011 1.03
122 Processing of autophagic protein LC3 by the 20S proteasome. Autophagy 2010 1.02
123 Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS). Mol Cell Proteomics 2013 1.01
124 Automated serum peptide profiling. Nat Protoc 2006 1.01
125 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes Dev 2013 1.01
126 Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J Biol Chem 2010 0.99
127 Pathway-based biomarker search by high-throughput proteomics profiling of secretomes. J Proteome Res 2009 0.97
128 Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem 2007 0.96
129 Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH. J Biol Chem 2003 0.96
130 Parkinson's disease-associated alpha-synuclein is a calmodulin substrate. J Biol Chem 2003 0.96
131 Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells. Protein Sci 2006 0.96
132 Data analysis of assorted serum peptidome profiles. Nat Protoc 2007 0.95
133 Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med 2012 0.95
134 Mutual targeting of mediator and the TFIIH kinase Kin28. J Biol Chem 2004 0.95
135 Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. FEBS Lett 2004 0.92
136 Affinity capture of specific DNA-binding proteins for mass spectrometric identification. Anal Chem 2003 0.91
137 Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. EMBO J 2004 0.90
138 Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Sci Signal 2011 0.89
139 JAMP optimizes ERAD to protect cells from unfolded proteins. Mol Biol Cell 2008 0.88
140 Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometry. Nat Protoc 2009 0.88
141 SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. PLoS One 2010 0.87
142 Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J Biol Chem 2005 0.86
143 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. Proc Natl Acad Sci U S A 2003 0.85
144 Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. J Immunol 2009 0.85
145 OvaCheck: let's not dismiss the concept. Nature 2004 0.84
146 PU.1 and a TTTAAA element in the myeloid defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function. J Immunol 2006 0.83
147 The laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling. Proc Natl Acad Sci U S A 2003 0.83
148 The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function. EMBO Rep 2003 0.82
149 Isolation and mass spectrometry of specific DNA binding proteins. Methods Mol Biol 2006 0.80
150 Distilling cancer biomarkers from the serum peptidome: high technology reading of tea leaves or an insight to clinical systems biology? J Clin Oncol 2005 0.79
151 Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol 2013 0.78
152 Super-SILAC for tumors and tissues. Nat Methods 2010 0.77
153 Aminopeptidase activities as prospective urinary biomarkers for bladder cancer. Proteomics Clin Appl 2014 0.76
154 Delayed-late activation of a myeloid defensin minimal promoter by retinoids and inflammatory mediators. Leuk Res 2004 0.76
155 Strategies for handling polypeptides on a micro-scale. Methods Mol Biol 2003 0.75