Published in Mol Cell on June 01, 2002
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol (2006) 5.01
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature (2011) 3.10
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol (2007) 2.39
Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res (2010) 2.36
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat Cell Biol (2010) 2.35
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell (2010) 2.32
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20
Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell (2007) 2.07
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol (2010) 2.04
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis. Cell Stem Cell (2012) 2.03
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem (2008) 1.99
Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis. PLoS Pathog (2010) 1.98
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. Oncogene (2008) 1.90
SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proc Natl Acad Sci U S A (2006) 1.85
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog (2009) 1.67
A methylation-mediator complex in hormone signaling. Genes Dev (2004) 1.61
Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression. Mol Cell Biol (2006) 1.60
A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev (2007) 1.60
Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res (2013) 1.55
MBT domain proteins in development and disease. Semin Cell Dev Biol (2009) 1.49
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc Natl Acad Sci U S A (2011) 1.46
Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. Mol Cell (2009) 1.45
Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster. J Cell Biol (2007) 1.44
The histone-like NF-Y is a bifunctional transcription factor. Mol Cell Biol (2008) 1.40
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem (2008) 1.38
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Establishment of histone modifications after chromatin assembly. Nucleic Acids Res (2009) 1.36
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J (2011) 1.33
Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications. Genome Res (2014) 1.32
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29
Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem (2009) 1.28
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci U S A (2009) 1.27
Protein modifications in transcription elongation. Biochim Biophys Acta (2008) 1.26
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Mol Cell (2009) 1.23
The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev (2012) 1.22
Histone lysine methyltransferases and demethylases in Plasmodium falciparum. Int J Parasitol (2008) 1.22
A peek into the complex realm of histone phosphorylation. Mol Cell Biol (2011) 1.22
Chromatin and DNA replication. Cold Spring Harb Perspect Biol (2013) 1.22
Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med (2015) 1.21
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20
The Drosophila roX1 RNA gene can overcome silent chromatin by recruiting the male-specific lethal dosage compensation complex. Genetics (2003) 1.20
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics (2012) 1.19
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation. Mol Cell Biol (2011) 1.19
Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res (2010) 1.17
SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes. Mol Cell Biol (2007) 1.17
Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor. PLoS One (2011) 1.16
Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. J Biol Chem (2008) 1.14
The activity of HDAC8 depends on local and distal sequences of its peptide substrates. Biochemistry (2008) 1.14
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem (2010) 1.13
Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Radiat Res (2010) 1.12
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J (2011) 1.11
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J Biol Chem (2009) 1.11
Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med (2009) 1.10
Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Nat Struct Mol Biol (2010) 1.08
A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenetics Chromatin (2011) 1.08
Mechanisms regulating epidermal stem cells. EMBO J (2012) 1.07
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem (2014) 1.05
Histone demethylases and cancer. Adv Cancer Res (2009) 1.05
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes. Mol Cell Biol (2012) 1.02
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One (2012) 1.01
Selective inhibitors of protein methyltransferases. J Med Chem (2014) 1.01
H4K20 methylation regulates quiescence and chromatin compaction. Mol Biol Cell (2013) 0.99
A combinatorial H4 tail library for exploring the histone code. Biochemistry (2008) 0.99
PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Mol Cell Biol (2008) 0.98
Targeting protein lysine methylation and demethylation in cancers. Acta Biochim Biophys Sin (Shanghai) (2012) 0.98
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol (2004) 21.56
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science (2008) 16.48
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Epigenetics: a landscape takes shape. Cell (2007) 8.29
Breaking barriers to transcription elongation. Nat Rev Mol Cell Biol (2006) 8.18
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
A unified theory of gene expression. Cell (2002) 7.61
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
Methylation as a crucial step in plant microRNA biogenesis. Science (2005) 7.16
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
RNA meets chromatin. Genes Dev (2005) 5.66
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science (2008) 5.48
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem (2003) 5.34
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14