Published in J Biol Chem on March 30, 2009
Nucleosomes are well positioned in exons and carry characteristic histone modifications. Genome Res (2009) 3.95
Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol (2012) 3.52
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem (2011) 2.63
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes. Genes Dev (2015) 1.56
Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell (2016) 1.44
Mediator complex regulates alternative mRNA processing via the MED23 subunit. Mol Cell (2012) 1.41
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res (2014) 1.37
Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13
Chromatin and epigenetic regulation of pre-mRNA processing. Hum Mol Genet (2012) 1.10
Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels. Mol Syst Biol (2012) 1.10
Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress. Mol Biol Cell (2009) 1.04
hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res (2012) 1.01
Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep (2011) 0.95
Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation. J Biol Chem (2013) 0.91
Set2 mediated H3 lysine 36 methylation: regulation of transcription elongation and implications in organismal development. Wiley Interdiscip Rev Dev Biol (2013) 0.86
Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases. J Biol Chem (2013) 0.83
The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J (2015) 0.82
Histone methyltransferases: novel targets for tumor and developmental defects. Am J Transl Res (2015) 0.82
Regulatory feedback from nascent RNA to chromatin and transcription. Nat Rev Mol Cell Biol (2017) 0.80
SETD2: an epigenetic modifier with tumor suppressor functionality. Oncotarget (2016) 0.78
HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells. Sci Rep (2016) 0.78
Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos. PLoS One (2014) 0.78
Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae. Bioessays (2015) 0.77
Writing, erasing and reading histone lysine methylations. Exp Mol Med (2017) 0.75
Proteomic analysis of chicken peripheral blood mononuclear cells after infection by Newcastle disease virus. J Vet Sci (2014) 0.75
Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Sci Rep (2017) 0.75
Translating the histone code. Science (2001) 56.77
Chromatin modifications and their function. Cell (2007) 55.98
The role of chromatin during transcription. Cell (2007) 26.48
Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem (2003) 21.11
The complex language of chromatin regulation during transcription. Nature (2007) 16.97
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell (1981) 12.26
An extensive network of coupling among gene expression machines. Nature (2002) 11.84
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66
Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet (2009) 8.11
A unified theory of gene expression. Cell (2002) 7.61
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev (2003) 4.93
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem (2005) 4.78
Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell (2005) 4.77
Histone ubiquitination: triggering gene activity. Mol Cell (2008) 4.42
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II. J Biol Chem (2003) 4.13
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J (2007) 3.81
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol (2005) 3.79
Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation. J Biol Chem (2002) 3.70
Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science (2007) 3.69
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem (2006) 3.14
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev (2005) 2.70
Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem (2005) 2.68
HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev (1995) 2.57
Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA (2007) 2.48
HnRNP L represses exon splicing via a regulated exonic splicing silencer. EMBO J (2005) 2.20
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19
The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. Nature (1980) 2.12
Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana. Mol Cell Biol (2007) 1.86
Combinatorial control of signal-induced exon repression by hnRNP L and PSF. Mol Cell Biol (2007) 1.62
Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Mol Cell Biol (2006) 1.58
Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. Mol Cell Biol (2005) 1.50
Insights into the mechanisms of splicing: more lessons from the ribosome. Genes Dev (2005) 1.41
Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Mol Cell Biol (2008) 1.28
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
A unified theory of gene expression. Cell (2002) 7.61
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96
Molecular signals of epigenetic states. Science (2010) 4.81
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2008) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest (2006) 4.37
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol (2002) 4.12
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell (2002) 4.08
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev (2002) 4.07
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol (2004) 3.90
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell (2009) 3.90