The interface between innate and adaptive immunity.

PubWeight™: 3.28‹?› | Rank: Top 1%

🔗 View Article (PMID 15454919)

Published in Nat Immunol on October 01, 2004

Authors

Kasper Hoebe1, Edith Janssen, Bruce Beutler

Author Affiliations

1: Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

Articles citing this

(truncated to the top 100)

The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish. BMC Dev Biol (2007) 3.44

Reconstructing immune phylogeny: new perspectives. Nat Rev Immunol (2005) 2.95

A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89

Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. J Virol (2006) 2.61

Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe (2008) 2.40

Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution. Hepatology (2012) 2.14

Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nat Immunol (2015) 2.08

Molecular and cellular signatures of human vaccine adjuvants. Proc Natl Acad Sci U S A (2008) 2.02

Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96

Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev (2005) 1.94

Specificity and complexity of the Caenorhabditis elegans innate immune response. Mol Cell Biol (2007) 1.78

MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A (2008) 1.74

Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. J Immunol (2009) 1.66

Innate immunity in the lungs. Proc Am Thorac Soc (2005) 1.66

Natural health products, modulation of immune function and prevention of chronic diseases. Evid Based Complement Alternat Med (2005) 1.51

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood (2009) 1.50

Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell (2015) 1.48

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med (2007) 1.44

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology (2005) 1.41

Animal models of colitis-associated carcinogenesis. J Biomed Biotechnol (2011) 1.33

C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol (2009) 1.32

Salmonella pathogenicity and host adaptation in chicken-associated serovars. Microbiol Mol Biol Rev (2013) 1.27

Expression and distribution of Toll-like receptors in the brain during murine neurocysticercosis. J Neuroimmunol (2006) 1.24

Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun (2005) 1.23

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. Blood (2005) 1.22

Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res (2006) 1.20

Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature. Proc Natl Acad Sci U S A (2009) 1.20

Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages. Br J Pharmacol (2006) 1.19

Vaccines for the 21st century. EMBO Mol Med (2014) 1.17

Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything. J Intern Med (2010) 1.17

Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response. Open Biol (2011) 1.14

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol (2011) 1.14

Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci (2009) 1.13

The role of Toll-like receptors in CNS response to microbial challenge. J Neurochem (2006) 1.12

TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol (2011) 1.12

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci U S A (2014) 1.10

Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med (2007) 1.10

Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis. J Leukoc Biol (2010) 1.09

Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock. PLoS One (2010) 1.07

Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection. Anat Rec (Hoboken) (2010) 1.06

Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther (2006) 1.06

Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Res Ther (2005) 1.05

Role for MyD88 signaling in murine gammaherpesvirus 68 latency. J Virol (2008) 1.05

Mechanisms of action of adjuvants. Front Immunol (2013) 1.05

Innate immunity in Drosophila: Pathogens and pathways. Insect Sci (2008) 1.04

Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters. Antimicrob Agents Chemother (2006) 1.03

The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1. BMC Immunol (2008) 1.02

Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses. Clin Vaccine Immunol (2006) 1.02

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita. Phytochemistry (2008) 1.02

Lactobacilli, bifidobacteria and E. coli nissle induce pro- and anti-inflammatory cytokines in peripheral blood mononuclear cells. World J Gastroenterol (2006) 1.02

TB, or not TB: that is the question -- does TLR signaling hold the answer? J Clin Invest (2004) 1.01

Update on toll-like receptor-directed therapies for human disease. Ann Rheum Dis (2007) 1.00

MyD88 plays an essential role in inducing B cells capable of differentiating into antibody-secreting cells after vaccination. J Virol (2011) 1.00

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol (2009) 0.99

The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation. J Biol Chem (2011) 0.99

The varying faces of IL-6: From cardiac protection to cardiac failure. Cytokine (2015) 0.98

Targeting Toll-like receptors for treatment of SLE. Mediators Inflamm (2010) 0.98

Toll-like receptor-independent triggering of dendritic cell maturation by viruses. J Virol (2006) 0.97

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int Immunopharmacol (2007) 0.97

Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system. Theor Biol Med Model (2010) 0.96

Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol (2008) 0.96

Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients. Malar J (2011) 0.96

Increased disease severity of parasite-infected TLR2-/- mice is correlated with decreased central nervous system inflammation and reduced numbers of cells with alternatively activated macrophage phenotypes in a murine model of neurocysticercosis. Infect Immun (2011) 0.96

Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell Mol Immunol (2011) 0.95

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. Int Immunol (2008) 0.94

Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood (2005) 0.93

Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases. Indian J Med Res (2013) 0.93

Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLoS Pathog (2009) 0.93

A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J Exp Med (2009) 0.93

The innate immune system in Alzheimer's disease. Int J Cell Biol (2013) 0.92

How did our complex immune system evolve? Nat Rev Immunol (2010) 0.92

Blowing on embers: commensal microbiota and our immune system. Front Immunol (2014) 0.90

PRRDB: a comprehensive database of pattern-recognition receptors and their ligands. BMC Genomics (2008) 0.90

Maturation-dependent responses of human neuronal cells to western equine encephalitis virus infection and type I interferons. Virology (2007) 0.89

Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology. J Clin Invest (2006) 0.89

Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice. Clin Exp Immunol (2005) 0.89

Comparison of different live vaccine strategies in vivo for delivery of protein antigen or antigen-encoding DNA and mRNA by virulence-attenuated Listeria monocytogenes. Infect Immun (2006) 0.88

Understanding the Impact of Infection, Inflammation, and Their Persistence in the Pathogenesis of Bronchopulmonary Dysplasia. Front Med (Lausanne) (2015) 0.88

Vaccine adjuvants - Current status and prospects on controlled release adjuvancity. Saudi Pharm J (2011) 0.88

Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice. Am J Pathol (2012) 0.88

Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor. Physiol Genomics (2009) 0.88

The ambiguity in immunology. Front Immunol (2012) 0.87

Sputum IgE and cytokines in asthma: relationship with sputum cellular profile. PLoS One (2013) 0.87

The role of platelets in the recruitment of leukocytes during vascular disease. Platelets (2015) 0.87

Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses. J Immune Based Ther Vaccines (2006) 0.86

Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator. J Virol (2014) 0.85

Hydrogen peroxide in inflammation: messenger, guide, and assassin. Adv Hematol (2012) 0.85

Flavonoid naringenin: a potential immunomodulator for Chlamydia trachomatis inflammation. Mediators Inflamm (2013) 0.85

Effect of vaginal immunization with HIVgp140 and HSP70 on HIV-1 replication and innate and T cell adaptive immunity in women. J Virol (2014) 0.85

The SPINK gene family and celiac disease susceptibility. Immunogenetics (2007) 0.84

CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor. FEBS Lett (2007) 0.84

To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses. Viruses (2016) 0.83

Rhipicephalus microplus salivary gland molecules induce differential CD86 expression in murine macrophages. Parasit Vectors (2010) 0.83

Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation. FEBS Lett (2008) 0.83

Immunopathogenesis of abdominal sepsis. Langenbecks Arch Surg (2014) 0.83

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings. Biochemistry (2011) 0.83

Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses. Expert Opin Ther Targets (2010) 0.83

Overview of toll-like receptors in the CNS. Curr Top Microbiol Immunol (2009) 0.83

Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther (2013) 0.83

Articles by these authors

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27

Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol (2005) 7.74

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51

CD14 is required for MyD88-independent LPS signaling. Nat Immunol (2005) 5.20

CD36 is a sensor of diacylglycerides. Nature (2005) 5.20

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88

Intracellular toll-like receptors. Immunity (2010) 4.66

Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (2009) 4.45

Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72

The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med (2007) 3.45

Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity (2007) 3.38

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem (2007) 2.82

Plant and animal sensors of conserved microbial signatures. Science (2010) 2.16

Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07

Toll-like receptors. Curr Biol (2011) 2.06

Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (2012) 1.98

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol (2011) 1.96

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology (2007) 1.94

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A (2006) 1.88

ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet (2007) 1.83

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity (2006) 1.78

An essential role for Rxr alpha in the development of Th2 responses. Eur J Immunol (2005) 1.74

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med (2007) 1.73

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci U S A (2010) 1.73

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A (2009) 1.69

The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J Immunol (2005) 1.65

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A (2011) 1.59

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis. Genetics (2010) 1.56

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.55

A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med (2009) 1.53

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol (2006) 1.52

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity (2007) 1.50

LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J Endotoxin Res (2004) 1.42

Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J Immunol (2005) 1.42

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A (2004) 1.41

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol (2010) 1.39

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur J Immunol (2004) 1.39

Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A (2005) 1.39

Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol (2007) 1.38

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res (2003) 1.38

A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet (2008) 1.36

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. Br J Haematol (2009) 1.36

Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur J Immunol (2006) 1.32

Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol (2009) 1.31

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. Blood (2009) 1.29

ENU-induced phenovariance in mice: inferences from 587 mutations. BMC Res Notes (2012) 1.28

Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics (2004) 1.28

R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol (2006) 1.27

Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem (2002) 1.26

Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome (2006) 1.23

The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic (2008) 1.22

UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog (2010) 1.22

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A (2012) 1.19

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity. Immunobiology (2007) 1.18

Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One (2011) 1.18

Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J (2007) 1.17

Bulk segregation mapping of mutations in closely related strains of mice. Genetics (2010) 1.15

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet (2013) 1.14

A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A (2008) 1.13

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proc Natl Acad Sci U S A (2011) 1.13

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol (2010) 1.13

ENU mutagenesis in mice. Methods Mol Biol (2008) 1.13

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS One (2009) 1.12

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development (2006) 1.10

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A (2013) 1.10

iRhom2 is required for the secretion of mouse TNFα. Blood (2012) 1.08

Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. Circ Res (2011) 1.08

Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood (2011) 1.08

Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res (2011) 1.07

Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency. J Immunol (2010) 1.07

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants? Trends Immunol (2013) 1.05

How the mighty have fallen: fatal infectious diseases of divine composers. Infect Dis Clin North Am (2004) 1.03

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol (2009) 1.03

Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol (2004) 1.02

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections. Proc Natl Acad Sci U S A (2011) 1.01

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proc Natl Acad Sci U S A (2010) 1.01

Sensors of the innate immune system: their link to rheumatic diseases. Nat Rev Rheumatol (2010) 1.00

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. J Immunol (2007) 1.00

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A (2010) 0.99

Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. J Biol Chem (2005) 0.99

Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Hum Immunol (2007) 0.98

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A (2010) 0.97

Impact of β2 integrin deficiency on mouse natural killer cell development and function. Blood (2011) 0.96

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci U S A (2011) 0.95

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. J Virol (2011) 0.95