Roles of IQGAP1 in cell polarization and migration.

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration. Nat Cell Biol (2011) 1.45

Cell-cell communication and axis specification in the Drosophila oocyte. Dev Biol (2007) 1.05

Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells. Oncogene (2008) 1.00

Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone. PLoS One (2009) 0.95

IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. PLoS One (2014) 0.91

S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. J Biol Chem (2012) 0.87

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. J Immunol (2012) 0.86

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation. Neural Plast (2015) 0.85

IQGAP1: a regulator of intracellular spacetime relativity. J Immunol (2012) 0.84

IQGAP1: insights into the function of a molecular puppeteer. Mol Immunol (2015) 0.80

Regulation of spine density and morphology by IQGAP1 protein domains. PLoS One (2013) 0.78

CRMPs colocalize and interact with cytoskeleton in hippocampal neurons. Int J Clin Exp Med (2015) 0.75

CRMP‑5 interacts with actin to regulate neurite outgrowth. Mol Med Rep (2015) 0.75

Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68

GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71

Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31

Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31

PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30

Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83

IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol (2002) 2.40

Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29

Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23

Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res (2003) 2.08

Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01

Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98

PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97

Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89

Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85

DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84

Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80

Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem (2005) 1.80

Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80

Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci (2009) 1.74

Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70

Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67

CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64

The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev (2002) 1.56

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation (2004) 1.53

A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51

Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46

Key regulators in neuronal polarity. Neuron (2005) 1.46

Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45

Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45

TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44

Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res (2009) 1.42

Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41

Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40

Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38

Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure (2006) 1.37

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet (2011) 1.36

Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol (2009) 1.35

Signaling networks in neuronal polarization. J Neurosci (2006) 1.35

Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep (2006) 1.32

Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun (2005) 1.29

AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem (2003) 1.28

Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27

DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci (2007) 1.27

Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension (2002) 1.24

IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci (2007) 1.24

Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Mol Biol Cell (2007) 1.23

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet (2008) 1.23

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci (2004) 1.21

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20

Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17

Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell (2004) 1.17

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J Cardiovasc Pharmacol (2006) 1.16

Axon specification in hippocampal neurons. Neurosci Res (2002) 1.16

CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem (2009) 1.14

Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin. J Cell Biol (2012) 1.12

Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. Cell Signal (2006) 1.11

Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes Cells (2005) 1.11

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells. J Mol Cell Cardiol (2004) 1.11

Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem (2003) 1.10

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10

EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J Cell Biol (2011) 1.10

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. J Biol Chem (2006) 1.09

Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells (2005) 1.07

Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. Schizophr Bull (2010) 1.07

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest (2013) 1.06

Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Biochem Biophys Res Commun (2005) 1.06

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J Biol Chem (2006) 1.06

Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. Biochem Biophys Res Commun (2007) 1.05

Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. J Biol Chem (2003) 1.04

Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun (2002) 1.04

Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain. J Neurosci (2011) 1.02

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J Immunol (2003) 1.02

Interaction of Rho-kinase with myosin II at stress fibres. Genes Cells (2004) 1.01

Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res (2003) 1.01

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem Biophys Res Commun (2010) 1.01

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol (2012) 1.01

CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. J Neurochem (2009) 1.00

Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J (2009) 1.00