Published in Lab Invest on January 01, 2006
Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood (2013) 2.05
Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res (2009) 1.85
Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest (2009) 1.70
Intravascular immunity: the host-pathogen encounter in blood vessels. Nat Rev Immunol (2009) 1.60
TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem (2008) 1.55
Virulence factors of the oral spirochete Treponema denticola. J Dent Res (2010) 1.35
Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease. Toxins (Basel) (2010) 1.26
LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium. J Histochem Cytochem (2007) 1.25
A critical review of human endotoxin administration as an experimental paradigm of depression. Neurosci Biobehav Rev (2009) 1.24
Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin. J Immunol (2011) 1.23
Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver. Hepatology (2010) 1.20
An evolving new paradigm: endothelial cells--conditional innate immune cells. J Hematol Oncol (2013) 1.17
Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice. Am J Pathol (2007) 1.16
Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat Inflamm Allergy Drug Discov (2009) 1.14
The immunobiology of toll-like receptor 4 agonists: from endotoxin tolerance to immunoadjuvants. Shock (2013) 1.12
Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability. J Cell Physiol (2009) 1.10
Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. Neuroimage (2012) 1.08
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience (2010) 1.07
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther (2006) 1.06
Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery. Cell Mol Neurobiol (2009) 1.05
Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04
(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. J Pain (2012) 1.00
The role of thrombomodulin lectin-like domain in inflammation. J Biomed Sci (2012) 1.00
Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. J Immunol (2013) 0.99
Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells. J Immunol (2012) 0.96
Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis. Clin Exp Immunol (2009) 0.95
Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma. Eur Arch Otorhinolaryngol (2006) 0.95
Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation. J Physiol (2012) 0.95
Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells. J Neuroinflammation (2010) 0.95
An aerobiological perspective of dust in cage-housed and floor-housed poultry operations. J Occup Med Toxicol (2009) 0.95
Molecular pathways mediating differential responses to lipopolysaccharide between human and baboon arterial endothelial cells. Clin Exp Pharmacol Physiol (2009) 0.95
Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions. J Anat (2009) 0.94
Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation. Mol Pain (2010) 0.93
Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther (2012) 0.93
Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo. J Infect Dis (2009) 0.93
9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol, from Eulophia ochreata, inhibits inflammatory signalling mediated by Toll-like receptors. Br J Pharmacol (2010) 0.92
Annexin A2: biology and relevance to the antiphospholipid syndrome. Lupus (2008) 0.92
TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators. PLoS One (2014) 0.91
Atrial natriuretic peptide protects against Staphylococcus aureus-induced lung injury and endothelial barrier dysfunction. J Appl Physiol (1985) (2010) 0.91
Relationship between microbial translocation and endothelial function in HIV infected patients. PLoS One (2012) 0.91
Critical role of Cdc42 in mediating endothelial barrier protection in vivo. Am J Physiol Lung Cell Mol Physiol (2008) 0.91
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia. J Biol Chem (2012) 0.90
GroEL and lipopolysaccharide from Francisella tularensis live vaccine strain synergistically activate human macrophages. Infect Immun (2010) 0.90
Translating innate response into long-lasting antibody response by the intrinsic antigen-adjuvant properties of papaya mosaic virus. Immunology (2007) 0.90
Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas. J Transl Med (2011) 0.89
Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway. Arterioscler Thromb Vasc Biol (2012) 0.89
Impaired immune tolerance to Porphyromonas gingivalis lipopolysaccharide promotes neutrophil migration and decreased apoptosis. Infect Immun (2010) 0.89
The modulatory effects of lipopolysaccharide-stimulated B cells on differential T-cell polarization. Immunology (2008) 0.89
The expression of E-selectin and chemokines in the cultured human lymphatic endothelium with lipopolysaccharides. J Anat (2008) 0.88
Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels. PLoS One (2013) 0.87
Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase. Redox Biol (2015) 0.87
Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells. Arch Pharm Res (2013) 0.86
Novel mechanism of attenuation of LPS-induced NF-κB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol (2014) 0.86
Effect of TLR4/MyD88 signaling pathway on expression of IL-1β and TNF-α in synovial fibroblasts from temporomandibular joint exposed to lipopolysaccharide. Mediators Inflamm (2015) 0.86
p120-Catenin: a novel regulator of innate immunity and inflammation. Crit Rev Immunol (2012) 0.86
Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy. J Neurochem (2013) 0.85
Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Am J Respir Cell Mol Biol (2014) 0.85
A purified capsular polysaccharide markedly inhibits inflammatory response during endotoxic shock. Infect Immun (2012) 0.85
Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection. Mediators Inflamm (2010) 0.84
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells. J Cell Mol Med (2013) 0.83
Melatonin treatment in old mice enables a more youthful response to LPS in the brain. J Neuroimmunol (2006) 0.83
R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming. Blood (2011) 0.83
MicroRNA-19a regulates lipopolysaccharide-induced endothelial cell apoptosis through modulation of apoptosis signal-regulating kinase 1 expression. BMC Mol Biol (2015) 0.82
Paricalcitol attenuates lipopolysaccharide-induced myocardial inflammation by regulating the NF-κB signaling pathway. Int J Mol Med (2016) 0.82
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One (2014) 0.82
Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy. Neuroscience (2012) 0.81
Cell-type-specific crosstalk between p38 MAPK and Rho signaling in lung micro- and macrovascular barrier dysfunction induced by Staphylococcus aureus-derived pathogens. Transl Res (2013) 0.81
Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis. J Pediatr Surg (2008) 0.81
Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. Am J Physiol Lung Cell Mol Physiol (2015) 0.81
Hypoxia augments lipopolysaccharide-induced cytokine expression in periodontal ligament cells. Inflammation (2014) 0.81
Matrine attenuates endotoxin-induced acute liver injury after hepatic ischemia/reperfusion in rats. Surg Today (2011) 0.81
Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation. Respir Res (2011) 0.81
p38 mitogen-activated protein kinase mediates lipopolysaccharide and tumor necrosis factor alpha induction of shiga toxin 2 sensitivity in human umbilical vein endothelial cells. Infect Immun (2007) 0.81
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice. Cardiovasc Diabetol (2014) 0.80
EOLA1 protects lipopolysaccharide induced IL-6 production and apoptosis by regulation of MT2A in human umbilical vein endothelial cells. Mol Cell Biochem (2014) 0.80
Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem (2012) 0.80
Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns. Brain Behav Immun (2009) 0.80
Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kappaB activation and apoptosis. Comp Immunol Microbiol Infect Dis (2008) 0.80
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Am J Pathol (2009) 0.80
RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure? Sci Rep (2015) 0.80
The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals. J Transl Med (2015) 0.79
Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis. PLoS One (2014) 0.79
Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis (2014) 0.79
IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats. Dig Dis Sci (2012) 0.78
Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease. Int J Mol Sci (2014) 0.78
Cytoprotection of perfluorocarbon on PMVECs in vitro. Inflammation (2013) 0.78
Bacterial PAMPs and Allergens Trigger Increase in [Ca(2+)]i-induced Cytokine Expression in Human PDL Fibroblasts. Korean J Physiol Pharmacol (2015) 0.78
Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases. Acta Pharmacol Sin (2011) 0.78
Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals. Int J Mol Sci (2011) 0.77
Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2. Infect Immun (2014) 0.77
Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function. Am J Physiol Lung Cell Mol Physiol (2015) 0.77
Effect of lipopolysaccharide on the characteristics of endothelial progenitor cells from bone marrow in mice. Mol Med Rep (2013) 0.76
Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected patients: a retrospective cross-sectional study. BMC Infect Dis (2016) 0.76
The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS One (2014) 0.76
Ymer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways. Mol Med (2012) 0.75
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma. Korean J Intern Med (2015) 0.75
Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine. Pharmacol Res Perspect (2015) 0.75
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med (2009) 4.03
Recent insights into the role of Notch signaling in tumorigenesis. Blood (2005) 3.37
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med (2007) 3.05
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol (2011) 2.27
Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol (2008) 2.21
Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res (2004) 2.10
Smooth Muscle alpha-actin is a direct target of Notch/CSL. Circ Res (2006) 1.90
Notch signaling in cardiac development. Circ Res (2008) 1.69
Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. J Thorac Oncol (2014) 1.55
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol (2002) 1.52
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood (2011) 1.44
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. J Clin Invest (2011) 1.42
Identification of sokotrasterol sulfate as a novel proangiogenic steroid. Circ Res (2006) 1.41
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood (2010) 1.36
Minimal contribution of marrow-derived endothelial precursors to tumor vasculature. J Immunol (2005) 1.31
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J Biol Chem (2003) 1.29
MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol (2010) 1.25
Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Dev Cell (2011) 1.22
Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling. FASEB J (2005) 1.21
Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases. FASEB J (2003) 1.12
Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells. J Biol Chem (2009) 1.07
Involvement of endothelial progenitor cells in tumor vascularization. Microvasc Res (2010) 1.06
FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction. Mol Cell Biol (2007) 1.04
Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-kappaB and c-Jun N-terminal kinase. Blood (2003) 1.03
Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase. J Immunol (2002) 1.03
The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression. Differentiation (2007) 1.02
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development. Cell Mol Life Sci (2012) 1.01
Notch-dependent cell cycle arrest is associated with downregulation of minichromosome maintenance proteins. Circ Res (2005) 0.99
Activation of vascular endothelial growth factor receptor-2 in bone marrow leads to accumulation of myeloid cells: role of granulocyte-macrophage colony-stimulating factor. J Immunol (2005) 0.99
Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model. J Am Soc Mass Spectrom (2005) 0.98
Notch signaling in the developing cardiovascular system. Am J Physiol Cell Physiol (2007) 0.97
Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. Blood (2004) 0.97
Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. J Biol Chem (2003) 0.96
Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling. Proc Natl Acad Sci U S A (2012) 0.95
SASH1 is a scaffold molecule in endothelial TLR4 signaling. J Immunol (2013) 0.94
Innate immune signaling in the myelodysplastic syndromes. Hematol Oncol Clin North Am (2010) 0.92
Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL. Am J Physiol Heart Circ Physiol (2007) 0.92
Role of the microenvironment in promoting angiogenesis in acute myeloid leukemia. Am J Hematol (2002) 0.90
Isolation and culture of primary endothelial cells. Methods Mol Biol (2005) 0.90
Vascularization predicts overall survival and risk of transformation in follicular lymphoma. Haematologica (2010) 0.89
Notch and minichromosome maintenance (MCM) proteins: integration of two ancestral pathways in cell cycle control. Cell Cycle (2006) 0.85
Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway. Am J Physiol Heart Circ Physiol (2011) 0.85
A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations. J Mol Diagn (2013) 0.85
Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal. Blood (2004) 0.84
Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations. Cancer Med (2012) 0.84
Mouse models of myelodysplastic syndromes. Leuk Res (2011) 0.84
Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell Cycle (2010) 0.82
RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal. J Biol Chem (2011) 0.82
Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B). Mol Cancer (2010) 0.81
Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal. Physiol Genomics (2009) 0.81
Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells. Cell Signal (2013) 0.80
Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism. Cancer Res (2014) 0.80
Notch activation promotes endothelial survival through a PI3K-Slug axis. Microvasc Res (2013) 0.80
Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. Am J Clin Pathol (2010) 0.79
Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leuk Res (2011) 0.79
Notch-dependent regulation of the ischemic vasodilatory response--brief report. Arterioscler Thromb Vasc Biol (2013) 0.79
A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn (2014) 0.79
Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34(+) cells from patients with del(5q) myelodysplastic syndrome. Haematologica (2012) 0.78
Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. PLoS One (2012) 0.78
Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies. BMC Genomics (2013) 0.77
Kleat: cleavage site analysis of transcriptomes. Pac Symp Biocomput (2015) 0.77
Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring. Haematologica (2011) 0.76
Tissue distribution of endothelial cells in vivo following intravenous injection. Exp Hematol (2006) 0.76
T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. Br J Haematol (2012) 0.75
Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leuk Res (2009) 0.75